Abstract: Articles and methods involving detection of binding between two or more species using MALDI are generally provided. In some embodiments, a method comprises exposing a first species to a composition comprising a second species, capturing the first species on a self-assembled monolayer, and performing MALDI on the self-assembled monolayer to generate a signal from the second species and a signal from a standard species present in the self-assembled monolayer. A ratio (first ratio) of the signal from the second species to the signal from the standard species may be compared to a cutoff value in order to determine if binding has occurred. This method may allow determination of a relative affinity of the second species for the first species.

Abstract: A method for generating instruction sequences for testing a processor design model. The method includes receiving, by an instruction sequence generator (ISG), an initial test template. The initial test template includes an initial set of instruction constraints and a save resumable state command. The ISG generates a first set of executable test instructions based on the initial test template. The ISG initiates the save resumable state command. The ISG creates and saves a snapshot that includes information on a resume state of the ISG and the first set of executable test instructions at the time the save resumable state command is initiated.

Abstract: The instant invention describes an extruder for shaping clay or similarly pliable materials into desired shapes. The extruder comprises an operational section, a cassette, and a die. The operational section comprises a plunger, a means for controlling movement of the plunger, a means for supplying electricity, and a body to provide an exterior housing. The cassette, which is removably attached to the operational section, comprises a cavity for holding extrusion material through which the plunger will pass. The die comprises an aperture used to shape the extrusion material and is able to he attached to the cassette.

Abstract: A method for treating multiple myeloma in a subject by administering 17-allylamino-17-demethoxy-geldanamycin or 17-amino geldanamycin, or a prodrug of either 17-AAG or 17-AG, to the subject.

Abstract: An endoscopic device including an elongate member having opposite ends, and a clevis attached to one end of the opposite ends. The clevis includes a barrel having at least one slot longitudinally extending completely through the barrel. The device includes a pair of jaws mounted on the clevis for pivotal movement. Each of the jaws has an end opposite the elongate member. The device includes an actuator member operatively connected to the pair of jaws for moving the jaws between a closed position in which the end of the corresponding jaw is positioned adjacent the other jaw and an open position in which an end of the jaw is spaced from the other jaw.

Abstract: Formulations comprising one or more epothilones together with a pharmaceutically acceptable carrier.

Abstract: Disclosed and described is a tool for forming objects from clay. The tool, commonly referred to as a rib, comprises at least one irregular curved edge and a centrally located hole. The tool also comprises a curved taper region between the hole and the irregular curved edge.

Abstract: A unique hernia repair stapler is described which allows the forming of staples to attach prosthetics to tissue, or to approximate herniated tissue. The staple is useful in endoscopic operations and may be rotatable or stationary. The stapler has a unique forming and ejecting mechanism; as well, there is the availability of a loading mechanism useful for both cartridges and magazines of staples. An improved staple shape allows for better staple alignment, especially in a multiple load device.

Abstract: A unique hernia repair stapler is described which allows the forming of staples to attach prosthetics to tissue, or to approximate herniated tissue. The staple is useful in endoscopic operations and may be rotatable or stationary. The stapler has a unique forming and electing mechanism; as well, there is the availability of a loading mechanism useful for both cartridges and magazines of staples. An improved staple shape allows for better staple alignment, especially in a multiple load device.

Abstract: A unique hernia repair stapler is described which allows the forming of staples to attach prosthetics to tissue, or to approximate herniated tissue. The staple is useful in endoscopic operations and may be rotatable or stationary. The stapler has a unique forming and ejecting mechanism; as well, there is the availability of a loading mechanism useful for both cartridges and magazines of staples. An improved staple shape allows for better staple alignment, especially in a multiple load device.