Abstract: Provided in some aspects are methods for light-controlled in situ surface patterning of a substrate comprising a step of blocking or ablating oligonucleotide molecules in a boundary region separating a plurality of spot regions, and attaching oligonucleotides to oligonucleotide molecules in a first one or more of the spot regions.

Abstract: Thrombin-inhibiting acylated pyrazole-pyridone compounds of formula (II) are disclosed herein, as well as pharmaceutical compositions, including tablets, that contain acylated pyrazole-pyridone compounds. These compounds are useful for the treatment and prevention of thrombin-related related diseases and disorders. Processes for making tablets containing acylated pyrazole-pyridones are also included.

Abstract: An aerosol provision system includes a consumable with an aerosol generator and aerosol-generating material, and an aerosol provision device to control power provided to the aerosol generator to energize the aerosol-generating material to generate aerosol. The consumable is one of a plurality of types of consumable having target values of an electrical characteristic that are associated with respective power modes of different levels of power for different amounts of aerosol generated from the aerosol-generating material. The aerosol provision device measures the electrical characteristic of the consumable to obtain a value, and identifies one of the target values that most closely matches the value. The one of the target values is associated with one of the power modes of a respective one of the different levels of power. And the aerosol provision device controls the power provided to the aerosol generator to the respective one of the different levels of power.

Abstract: The disclosure provides a method for generating an index file of a semantic search engine, and a method for generating a response to a user text query using the index file of the semantic search engine. The disclosure enables semantic searching of text documents or text data items to be performed.

Abstract: A Raman endoscope for use in obtaining in vivo Raman spectra in the peripheral airways of the lungs and a method of constructing the Raman endoscope are disclosed. The endoscope has a tubular sheath containing a fiber bundle. The sheath has an outer diameter of less than 1.35 mm. The sheath is made of fluorinated ethylene propylene. The sheath is flexible along its length from a first end to a point along the sheath so that it can navigate sharp turns within the peripheral airways. A layer of coating covers the sheath along a terminal length and a probe tip of the fiber bundle. The terminal length extends along a length of the sheath extending from a second end opposite to the first end to the point. Terminal length is rigid to facilitate advancement of the endoscope towards the lesion of interest. Terminal length is 5 mm or less.

Abstract: Anti-fouling coatings and associated systems and methods are generally described. In some aspects, a system comprises a substrate, a coating disposed on at least a portion of the substrate, and a fluid comprising one or more foulants, where the coating is configured to be in physical contact with the fluid during use. According to some embodiments, a full-spectral Hamaker constant associated with the coating and the fluid is relatively low (e.g., about 20 zj or less, about 10 zj or less), and the van der Waals (vdW) force between the coating and the one or more foulants is, therefore, correspondingly low. Under some conditions (e.g., high temperature and/or high pressure conditions), intermolecular interactions between the coating and the one or more foulants may he dominated by the vdW force, and a relatively low vdW force may reduce the likelihood of the one or more foulants adhering to and/or otherwise being deposited on the coating.

Abstract: Composite anti-fouling coatings and associated systems and methods are generally described. In some aspects, a system comprises a substrate, a composite coating disposed on at least a portion of the substrate, and a fluid comprising one or more foulants, where the composite coating is configured to be in physical contact with the fluid during use. The composite coating may comprise a first region comprising a first material and a second region comprising a second material that is different from the first material. According to some embodiments, a full- spectral Hamaker constant associated with the composite coating and the fluid (i.e., based on average optical properties of the first and second materials of the composite coating) is relatively low, and the van der Waals (vdW) force between the composite coating and the one or more foulants is, therefore, correspondingly low. Under some conditions (e.g.

Abstract: Thrombin-inhibiting acylated pyrazole-pyridone compounds of formula (II) are disclosed herein, as well as pharmaceutical compositions, including tablets, that contain acylated pyrazole-pyridone compounds. These compounds are useful for the treatment and prevention of thrombin-related related diseases and disorders. Processes for making tablets containing acylated pyrazole-pyridones are also included.

Abstract: A controller and method of classifying a user into one of a plurality of user classes. One or more voice samples are received from the user, from which a frequency spectrum is generated. One or more values defining respective features of the frequency spectrum are extracted from the frequency spectrum. Each of the respective features are defined by values of frequency, amplitude, and/or position in the spectrum. One or more of the respective features are resonant frequencies in the voice of the user. A user profile of the user is generated and comprises the extracted one or more values. The user profile is supplied to a machine learning algorithm that is trained to classify users as belonging to one of the plurality of user classes based on the one or more values in their respective user profile.

Abstract: A Raman endoscope for use in obtaining in vivo Raman spectra in the peripheral airways of the lungs and a method of constructing the Raman endoscope are disclosed. The endoscope has a tubular sheath containing a fiber bundle. The sheath has an outer diameter of less than 1.35 mm. The sheath is made of fluorinated ethylene propylene. The sheath is flexible along its length from a first end to a point along the sheath so that it can navigate sharp turns within the peripheral airways. A layer of coating covers the sheath along a terminal length and a probe tip of the fiber bundle. The terminal length extends along a length of the sheath extending from a second end opposite to the first end to the point. Terminal length is rigid to facilitate advancement of the endoscope towards the lesion of interest. Terminal length is 5 mm or less.

Abstract: There are provided inter alia multisubstituted aromatic compounds useful for the inhibition of thrombin, which compounds include substituted pyrazolyl or substituted triazolyl. There are additionally provided pharmaceutical compositions. There are additionally provided methods of treating and preventing a disease or disorder, which disease or disorder is amenable to treatment or prevention by the inhibition of thrombin.

Abstract: A controller and method of classifying a user into one of a plurality of user classes. One or more voice samples are received from the user, from which a frequency spectrum is generated. One or more values defining respective features of the frequency spectrum are extracted from the frequency spectrum. Each of the respective features are defined by values of frequency, amplitude, and/or position in the spectrum. One or more of the respective features are resonant frequencies in the voice of the user. A user profile of the user is generated and comprises the extracted one or more values. The user profile is supplied to a machine learning algorithm that is trained to classify users as belonging to one of the plurality of user classes based on the one or more values in their respective user profile.

Abstract: There are provided inter alia multisubstituted aromatic compounds useful for the inhibition of thrombin and/or kallikrein, which compounds include substituted pyrazolyl. There are additionally provided pharmaceutical compositions. There are additionally provided methods of treating and preventing certain diseases or disorders, which diseases or disorders are amenable to treatment or prevention by the inhibition of thrombin and/or kallikrein.

Abstract: There are provided inter alia multisubstituted aromatic compounds useful for the inhibition of thrombin and/or kallikrein, which compounds include substituted pyrazolyl. There are additionally provided pharmaceutical compositions. There are additionally provided methods of treating and preventing certain diseases or disorders, which diseases or disorders are amenable to treatment or prevention by the inhibition of thrombin and/or kallikrein.

Abstract: There are provided inter alia pyrazolyl-substituted pyridone compounds, which exhibit biological activity, e.g., inhibitory action, against serine proteases, including thrombin and various kallikreins. There are additionally provided pharmaceutical compositions. There are additionally provided methods of treating and preventing certain diseases or disorders, which disease or disorder is amenable to treatment or prevention by the inhibition of serine proteases, including thrombin and various kallikreins.

Abstract: There are provided inter alia multisubstituted aromatic compounds useful for the inhibition of kallikrein, which compounds include substituted pyrazolyl or substituted triazolyl. There are additionally provided pharmaceutical compositions. There are additionally provided methods of treating and preventing certain diseases or disorders, which disease or disorder is amenable to treatment or prevention by the inhibition of kallikrein.

Abstract: There are provided inter alia multisubstituted aromatic compounds useful for the inhibition of kallikrein, which compounds include substituted pyrazolyl or substituted triazolyl. There are additionally provided pharmaceutical compositions. There are additionally provided methods of treating and preventing certain diseases or disorders, which disease or disorder is amenable to treatment or prevention by the inhibition of kallikrein.

Abstract: Examples of a spectroscopy system with a specially design ambient illumination system are disclosed. The ambient illumination system comprises one or more light emitting diodes (LEDs) that provide illumination light in the wavelength of 400-785 nm. The ambient illumination system can further comprise a filter to block light above 785 nm. The filter can be placed directly in front of LED emitters. The LEDs can be white LEDs or RGB LEDs. The spectroscopy system can further comprise a control system that can receive a signal from the spectral probe when the spectral measurements commence and can instantaneously send a signal to automatically switch off the ambient illumination system and to receive a signal from the spectral probe when the spectral measurements are terminated and automatically switch on the ambient illumination system. Examples of methods of operating the spectroscopy system and the ambient illumination system are disclosed.

Abstract: There are provided inter alia pyrazolyl-substituted pyridone compounds, which exhibit biological activity, e.g., inhibitory action, against serine proteases, including thrombin and various kallikreins. There are additionally provided pharmaceutical compositions. There are additionally provided methods of treating and preventing certain diseases or disorders, which disease or disorder is amenable to treatment or prevention by the inhibition of serine proteases, including thrombin and various kallikreins.

Abstract: There are provided inter alia multisubstituted aromatic compounds useful for the inhibition of kallikrein, which compounds include substituted pyrazolyl or substituted triazolyl. There are additionally provided pharmaceutical compositions. There are additionally provided methods of treating and preventing certain diseases or disorders, which disease or disorder is amenable to treatment or prevention by the inhibition of kallikrein.