Abstract: Methods and compositions are provided for diagnosing lung cancer in a mammalian subject by use of 7 or more selected genes, e.g., a gene expression profile, from the blood of the subject which is characteristic of disease. The gene expression profile includes 7 or more genes of Table I, Table II, Table III, Table IV or Table IX herein.

Abstract: Methods and compositions are provided for diagnosing lung cancer in a mammalian subject by use of 7 or more selected genes, e.g., a gene expression profile, from the blood of the subject which is characteristic of disease. The gene expression profile includes 7 or more genes of Table I, Table II, Table III, Table IV or Table IX herein.

Abstract: A heat exchange apparatus includes a heat exchanger, a refrigerant adjustment component, and a first connecting member. The heat exchanger includes a first pipe, a second pipe, a plurality of heat exchange tubes connecting the first pipe and the second pipe, and an edge plate located on an outer side of the plurality of heat exchange tubes in a length direction of the first pipe. At least part of the refrigerant adjustment component is located on an outer side of the edge plate in the length direction of the first pipe. An included angle between an axis in a length direction of at least part of an outer wall of the refrigerant adjustment component and an axis in the length direction of the first pipe is greater than 0° and less than or equal to 90°.

Abstract: A heat exchange device includes a heat exchanger and a water guider. The water guider is arranged on the heat exchanger and has a water guide groove, and condensed water on at least a part of the heat exchanger can flow out through the water guide groove. The heat exchange device has a good drainage performance, can prevent the condensed water from accumulating, and thus improves a heat exchange area and a heat exchange efficiency of the heat exchanger.

Abstract: Methods and compositions are provided for diagnosing lung cancer in a mammalian subject by use of 10 or more selected genes, e.g., a gene expression profile, from the blood of the subject which is characteristic of disease. The gene expression profile includes 10 or more genes of Table I or Table II herein.

Abstract: Methods and compositions are provided for diagnosing lung cancer in a mammalian subject by use of 10 or more selected genes, e.g., a gene expression profile, from the blood of the subject which is characteristic of disease. The gene expression profile includes 10 or more genes of Table I or Table II herein.

Abstract: A heat exchange device includes a heat exchanger and a water guider. The water guider is arranged on the heat exchanger and has a water guide groove, and condensed water on at least a part of the heat exchanger can flow out through the water guide groove. The heat exchange device has a good drainage performance, can prevent the condensed water from accumulating, and thus improves a heat exchange area and a heat exchange efficiency of the heat exchanger.

Abstract: Methods and compositions are provided for diagnosing lung cancer in a mammalian subject by use of 7 or more selected genes, e.g., a gene expression profile, from the blood of the subject which is characteristic of disease. The gene expression profile includes 7 or more genes of Table I, Table II, Table III, Table IV or Table IX herein.

Abstract: Methods and compositions are provided for diagnosing lung cancer in a mammalian subject by use of three or more selected gene, e.g., a gene expression profile, from the peripheral blood mononuclear cells (PBMC) of the subject which is characteristic of disease, a stage of the disease, or enables prognosis of recurrence of disease. The gene expression profile includes three or more genes of Table I, Table II, Table III, Table IV, Table V, Table VI or Table VII herein. Detection of changes in expression in the selected genes forming the gene expression profile from that of a reference gene expression profile are correlated with non-small cell lung cancer (NSCLC). One composition for use in such diagnosis includes three or more PCR primer-probe sets, wherein each primer-probe set amplifies a different polynucleotide sequence from the gene expression profile.

Abstract: Methods and compositions are provided for diagnosing or detecting a condition, e.g., lung disease in a mammalian subject by use of a micro-RNA expression level or an expression level profile of multiple miRNA in the peripheral blood mononuclear cells (PBMC) of the subject which is characteristic of COPD or NSCLC. Detection of changes in expression in specific miRNA biomarkers from that of a reference sample or miRNA expression profile are correlated with non-small cell lung cancer (NSCLC) and/or COPD and permit differentiation among healthy subjects, subjects with COPD and subjects with adenocarcinoma or squamous cell carcinoma.

Abstract: Methods and compositions are provided for diagnosing lung cancer in a mammalian subject by use of three or more selected gene, e.g., a gene expression profile, from the peripheral blood mononuclear cells (PBMC) of the subject which is characteristic of disease, a stage of the disease, or enables prognosis of recurrence of disease. The gene expression profile includes three or more genes of Table I, Table II, Table III, Table IV, Table V, Table VI or Table VII herein. Detection of changes in expression in the selected genes forming the gene expression profile from that of a reference gene expression profile are correlated with non-small cell lung cancer (NSCLC). One composition for use in such diagnosis includes three or more PCR primer-probe sets, wherein each primer-probe set amplifies a different polynucleotide sequence from the gene expression profile.

Abstract: Methods and compositions are provided for diagnosing or detecting a condition, e.g., lung disease in a mammalian subject by use of a micro-RNA expression level or an expression level profile of multiple miRNA in the peripheral blood mononuclear cells (PBMC) of the subject which is characteristic of COPD or NSCLC. Detection of changes in expression in specific miRNA biomarkers from that of a reference sample or miRNA expression profile are correlated with non-small cell lung cancer (NSCLC) and/or COPD and permit differentiation among healthy subjects, subjects with COPD and subjects with adenocarcinoma or squamous cell carcinoma.

Abstract: Methods and compositions are provided for diagnosing lung cancer in a mammalian subject by use of three or more selected gene, e.g., a gene expression profile, from the peripheral blood mononuclear cells (PBMC) of the subject which is characteristic of disease, a stage of the disease, or enables prognosis of recurrence of disease. The gene expression profile includes three or more genes of Table I, Table II, Table III, Table IV, Table V, Table VI or Table VII herein. Detection of changes in expression in the selected genes forming the gene expression profile from that of a reference gene expression profile are correlated with non-small cell lung cancer (NSCLC). One composition for use in such diagnosis includes three or more PCR primer-probe sets, wherein each primer-probe set amplifies a different polynucleotide sequence from the gene expression profile.

Abstract: Methods and compositions are provided for diagnosing lung cancer in a mammalian subject by use of three or more selected genes, e.g., a gene expression profile, from the peripheral blood mononuclear cells (PBMC) of the subject which is characteristic of disease, a stage of the disease, or enables prognosis of recurrence of disease. The gene expression profile includes three or more genes of Table I, Table II, Table III, Table IV, Table V, Table VI or Table VII herein. Detection of changes in expression in the selected genes forming the gene expression profile from that of a reference gene expression profile are correlated with non-small cell lung cancer (NSCLC). One composition for use in such diagnosis includes three or more PCR primer-probe sets, wherein each primer-probe set amplifies a different polynucleotide sequence from the gene expression profile.

Abstract: Methods and compositions are provided for diagnosing or detecting a condition, e.g., lung disease in a mammalian subject by use of a micro-RNA expression level or an expression level profile of multiple miRNA in the peripheral blood mononuclear cells (PBMC) of the subject which is characteristic of COPD or NSCLC. Detection of changes in expression in specific miRNA biomarkers from that of a reference sample or miRNA expression profile are correlated with non-small cell lung cancer (NSCLC) and/or COPD and permit differentiation among healthy subjects, subjects with COPD and subjects with adenocarcinoma or squamous cell carcinoma.

Abstract: Methods and compositions are provided for diagnosing lung cancer in a mammalian subject by use of three or more selected genes, e.g., a gene expression profile, from the peripheral blood mononuclear cells (PBMC) of the subject which is characteristic of disease, a stage of the disease, or enables prognosis of recurrence of disease. The gene expression profile includes three or more genes of Table I, Table II, Table III, Table IV, Table V, Table VI or Table VII herein. Detection of changes in expression in the selected genes forming the gene expression profile from that of a reference gene expression profile are correlated with non-small cell lung cancer (NSCLC). One composition for use in such diagnosis includes three or more PCR primer-probe sets, wherein each primer-probe set amplifies a different polynucleotide sequence from the gene expression profile.

Abstract: A method of developing a gene expression profile indicative of the presence or stage of a selected a disease, disorder or genetic pathology in a mammalian subject employs penalized discriminant analysis with recursive feature elimination. A method of diagnosing a cancer in a mammalian subject includes the steps of examining a sample containing the subject's immune cells and detecting a variance in the expression of a statistically significant number of genes, e.g., at least 10 non-tumor genes from those same genes in a characteristic disease or healthy gene expression profile. A significant variance in expression of these genes when compared to a gene expression profile, preferably an average gene expression profile of a normal control, or significant similarities to an average gene profile of subjects with cancer, correlates with a specific type of cancer and/or location of tumor.

Abstract: Articles that provide heating and/or cooling for wearers of various types of wearing apparel are disclosed. The articles comprise removable inserts for wearing apparel that are activated by exposure to air or breaking an internal bag of the insert and shaking the inserts to provide single use disposable inserts. The disposable inserts provide heating or cooling for an extended period of time. A reusable insert is disclosed that is activated by heating or by refrigeration to provide either heating or cooling. Heating or cooling is provided by wearing apparel comprising at least one chamber for a compressed gas cylinder. The chamber may be recharged as needed to provide continuous heating or cooling of a person's head or various parts of a person's body. In one embodiment, the articles comprise a length of tubing extending along at least a portion of the wearing apparel and an aperture for the release of gas from a compressed gas cylinder into the tubing.

Abstract: Articles that provide foot pain-relief for wearers of shoes and methods are disclosed. Foot pain relief by cooling or heating of footwear is provided by footwear comprising a length of tubing coupled to and along at least a portion of the shoe insole and an aperture for the release of gas from a compressed gas cylinder into the tubing. The shoe is recharged as needed to provide continuous cooling or heating of a foot.

Abstract: Articles that provide foot pain-relief for wearers of shoes and methods are disclosed. The foot pain-relief articles comprise removable inserts for foot wear that are activated by exposure to air or breaking an internal bag of the insert and shaking the inserts to provide single use disposable inserts. The disposable inserts provide warming or cooling for an extended period of time for foot pain-relief. A reusable insert is disclosed that is activated by refrigeration or by heating to provide either cooling or warming foot pain-relief. Foot pain relief by cooling of foot wear is provided by foot wear comprising a chamber and an aperture for a compressed gas cylinder. The chamber is recharged as needed to provide continuous cooling of a foot.