Patents by Inventor Michael Silberbach

Michael Silberbach has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • NATRIURETIC PEPTIDE RELATED FRAGMENT IN CARDIOVASCULAR DISEASE
    Publication number: 20110218230
    Abstract: This disclosure provides an intracellular fragment of natriuretic peptide receptor A (NPRA), referred to herein as soluble natriuretic peptide receptor-related fragment (sNRF). It is shown herein that sNRF causes NP resistance. Based on these observations, methods of treating a cardiovascular disorder by inhibiting the activity of sNRF are disclosed. Assays are provided that use sNRF to screen agents for their ability to increase the biological activity of an NPR, for example agents that increase the sensitivity of NPR for NPs (such as atrial natriuretic peptide, ANP), or that decrease growth factor deleterious effects, or combinations thereof. Also provided are agents identified using the disclosed assays, and methods of using the agents, for example to treat or diagnose a cardiovascular disorder, such as heart failure.
    Type: Application
    Filed: May 16, 2011
    Publication date: September 8, 2011
    Inventors: MICHAEL SILBERBACH, CHARLES T. ROBERTS, NATHAN AIRHART
  • Methods of screening using a natriuretic peptide receptor
    Patent number: 7943296
    Abstract: This disclosure provides an intracellular fragment of natriuretic peptide receptor A (NPRA), referred to herein as soluble natriuretic peptide receptor-related fragment (sNRF). It is shown herein that sNRF causes NP resistance. Based on these observations, methods of treating a cardiovascular disorder by inhibiting the activity of sNRF are disclosed. Assays are provided that use sNRF to screen agents for their ability to increase the biological activity of an NPR, for example agents that increase the sensitivity of NPR for NPs (such as atrial natriuretic peptide, ANP), or that decrease growth factor deleterious effects, or combinations thereof. Also provided are agents identified using the disclosed assays, and methods of using the agents, for example to treat or diagnose a cardiovascular disorder, such as heart failure.
    Type: Grant
    Filed: October 30, 2006
    Date of Patent: May 17, 2011
    Assignee: Oregon Health & Science University
    Inventors: Michael Silberbach, Charles T. Roberts, Nathan Airhart
  • NATRIURETIC PEPTIDE RELATED FRAGMENT IN CARDIOVASCULAR DISEASE
    Publication number: 20090312247
    Abstract: This disclosure provides an intracellular fragment of natriuretic peptide receptor A (NPRA), referred to herein as soluble natriuretic peptide receptor-related fragment (sNRF). It is shown herein that sNRF causes NP resistance. Based on these observations, methods of treating a cardiovascular disorder by inhibiting the activity of sNRF are disclosed. Assays are provided that use sNRF to screen agents for their ability to increase the biological activity of an NPR, for example agents that increase the sensitivity of NPR for NPs (such as atrial natriuretic peptide, ANP), or that decrease growth factor deleterious effects, or combinations thereof. Also provided are agents identified using the disclosed assays, and methods of using the agents, for example to treat or diagnose a cardiovascular disorder, such as heart failure.
    Type: Application
    Filed: October 30, 2006
    Publication date: December 17, 2009
    Inventors: Michael Silberbach, Charles T. Roberts, Nathan Airhart