Abstract: The present invention relates to compounds of formula (I): and methods useful for inhibiting the DNA polymerase IIIC enzyme. The invention also provides pharmaceutically acceptable compositions comprising compounds of the present invention and methods of using said compositions in the treatment of Gram-positive bacterial infections.

Abstract: The present invention relates to compounds and methods useful for inhibiting the DNA polymerase IIIC enzyme. The invention also provides pharmaceutically acceptable compositions comprising compounds of the present invention and methods of using said compositions in the treatment of Gram-positive bacteria infections.

Abstract: The invention relates to a non-invasive imaging method of bacteria. One embodiment comprises labeling the bacteria with a radioisotope, then delivering it to the gut of a human or animal. Another embodiment is to label bacteriophages, then administer them to a human or animal, so that they infect (and thus co-localize with) bacteria already resident in the human or animal. The bacteriophage can then be imaged, showing the location of the resident bacteria of interest. In another embodiment, the invention is related more generally to the labelling of bacteria or bacteriophages with a radio-metal or radioisotope to render the labeled gut bacteria and the bacteria in the body visible to nuclear medicine PET and SPECT imaging guided by functional/structural MRI and/or CT imaging.

Abstract: The present invention relates to compounds and methods useful for inhibiting the DNA polymerase IIIC enzyme. The invention also provides pharmaceutically acceptable compositions comprising compounds of the present invention and methods of using said compositions in the treatment of Gram-positive bacteria infections.

Abstract: The present invention relates to compounds and methods useful for inhibiting the DNA polymerase IIIC enzyme. The invention also provides pharmaceutically acceptable compositions comprising compounds of the present invention and methods of using said compositions in the treatment of Gram-positive bacterial infections.

Abstract: The present invention relates to compounds and methods useful for inhibiting the DNA polymerase IIIC enzyme. The invention also provides pharmaceutically acceptable compositions comprising compounds of the present invention and methods of using said compositions in the treatment of Gram-positive bacterial infections.

Abstract: The present invention relates to compounds and methods useful for inhibiting the DNA polymerase IIIC enzyme. The invention also provides pharmaceutically acceptable compositions comprising compounds of the present invention and methods of using said compositions in the treatment of Gram-positive bacterial infections.

Abstract: The present invention relates to compounds and methods useful for inhibiting the DNA polymerase IIIC enzyme. The invention also provides pharmaceutically acceptable compositions comprising compounds of the present invention and methods of using said compositions in the treatment of Gram-positive bacterial infections.

Abstract: The present invention relates to compounds and methods useful for inhibiting the DNA polymerase IIIC enzyme. The invention also provides pharmaceutically acceptable compositions comprising compounds of the present invention and methods of using said compositions in the treatment of Gram-positive bacteria infections.

Abstract: A system for a cleaning brush comprises a cleaning scrubber for cleaning household surfaces. The cleaning scrubber includes an elongated handle having a gripping portion at the proximal end and a means for removably attaching a cleaning disk at the distal end. The cleaning disk comprises a foam or sponge cleaning pad and means for attachment to the handle. The handle may include means for releasing the cleaning disk from the end of the handle without the need for the user to manually handle the cleaning disk. A caddy for storage of the cleaning scrubber and spare cleaning disks is also described.

Abstract: A collapsible container is provided having an outer liner defining a top, a bottom and vertical sides and an inner liner defining a plurality of sides corresponding to the vertical sides of the outer liner. The inner liner is attached to the outer liner at least at one of the top and the bottom of the outer liner, and each side of the inner liner defines a top edge, a bottom edge, and two side edges which extend vertically. A sleeve is attached to each of the edges of the inner liner at the top, bottom, and sides thereof. The sleeves define substantially circular tubes. A flexible frame is located between the outer liner and the inner liner and disposed within the plurality of sleeves to provide a flexible support and permits collapse and/or folding of the container.

Abstract: A system for a cleaning brush comprises a cleaning scrubber for cleaning household surfaces. The cleaning scrubber includes an elongated handle having a gripping portion at the proximal end and a means for removably attaching a cleaning disk at the distal end. The cleaning disk comprises a foam or sponge cleaning pad and means for attachment to the handle. The handle may include means for releasing the cleaning disk from the end of the handle without the need for the user to manually handle the cleaning disk. A caddy for storage of the cleaning scrubber and spare cleaning disks is also described.

Abstract: The present disclosure is directed to the upgrading of heavy hydrocarbon feedstock. The systems of the present disclosure provides for improved reactor geometries to create more efficient processing and upgrading of the feedstocks. The reactor geometry may be varied by the addition of periodic bumps on the reactor walls and/or by the tapering of the diameter of the upflow reactor.

Abstract: A cleaning scrubber for cleaning household surfaces is described. The cleaning scrubber includes an elongated handle having a gripping portion at the proximal end and a means for removably attaching a cleaning disk at the distal end. The cleaning disk comprises a foam or sponge cleaning pad and means for attachment to the handle. The handle may include means for releasing the cleaning disk from the end of the handle without the need for the user to manually handle the cleaning disk. A caddy for storage of the cleaning scrubber and spare cleaning disks is also described.

Abstract: A collapsible container is provided having an outer liner defining a top, a bottom and vertical sides and an inner liner defining a plurality of sides corresponding to the vertical sides of the outer liner. The inner liner is attached to the outer liner at least at one of the top and the bottom of the outer liner, and each side of the inner liner defines a top edge, a bottom edge, and two side edges which extend vertically. A sleeve is attached to each of the edges of the inner liner at the top, bottom, and sides thereof. The sleeves define substantially circular tubes. A flexible frame is located between the outer liner and the inner liner and disposed within the plurality of sleeves to provide a flexible support and permits collapse and/or folding of the container.