Abstract: A compound of Formula I, enantiomers, diasteriomers, tautomers or pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4 and R5 are defined herein, are useful as JAK kinase inhibitors. A pharmaceutical composition that includes a compound of Formula I and a pharmaceutically acceptable carrier, adjuvant or vehicle, and methods of treating or lessening the severity of a disease or condition responsive to the inhibition of JAK kinase activity in a patient are disclosed.

Abstract: A compound of Formula I, enantiomers, diasteriomers, tautomers or pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4 and R5 are defined herein, are useful as JAK kinase inhibitors. A pharmaceutical composition that includes a compound of Formula I and a pharmaceutically acceptable carrier, adjuvant or vehicle, and methods of treating or lessening the severity of a disease or condition responsive to the inhibition of JAK kinase activity in a patient are disclosed.

Abstract: The present invention provides a mounting mechanism for a removable bollard, which has high flexibility and convenience for the removal and reinstallation of the bollard and the socket for inserting the bollard can be covered without having additional devices after the removal of the bollard.

Abstract: Benzopyran and benzoxepin compounds of Formulas I and II, and including stereoisomers, geometric isomers, tautomers, solvates, metabolites and pharmaceutically acceptable salts thereof, are useful for inhibiting lipid kinases including p110 alpha and other isoforms of PI3K, and for treating disorders such as cancer mediated by lipid kinases. Methods of using compounds of Formulas I and II for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed.

Abstract: The present invention relates to novel compounds, to pharmaceutical compositions comprising the compounds described herein, their pharmaceutically acceptable salts, hydrates and solvates, as well as to the use of the compounds in medicine and for the preparation of a medicament which acts on the human 11-?-hydroxysteroid dehydrogenase type 1 enzyme (11?HSD1).

Abstract: The invention relates to an infill which can be inserted into a bollard footing hole. The infill is designed such that it allows a bollard to be fit over it, and the infill fits within a footing hole. Methods of covering a footing hole are also bought.

Abstract: The present invention provides a mounting mechanism for a removable bollard, which has high flexibility and convenience for the removal and reinstallation of the bollard and the socket for inserting the bollard can be covered without having additional devices after the removal of the bollard.

Abstract: The invention relates to an infill which can be inserted into a bollard footing hole. The infill is designed such that it allows a bollard to be fit over it, and the infill fits within a footing hole. Methods of covering a footing hole are also bought.

Abstract: A bollard with connecting mechanism for connecting railings, comprising: a bollard body which is provided with at least two receiving parts concave inwardly on each of opposite surfaces thereof; at least two connectors, each of which includes a base and an ear extending from the base and having a connecting hole thereon for connecting the railing; wherein the base is accommodated in the receiving part, and the ear is selectively accommodated in the receiving part or exposed out of the receiving part according to whether railings need to be connected.

Abstract: A filter comprises at least one filtration unit with a filtration passage having an inlet and an outlet, wherein the filtration unit includes at least one groove formed in an inlet side surface of the filtration unit, said at least one groove extending to the inlet and dimensioned to hold back substances which may clog the filtration passage, by means of upper edges of said at least one groove. According to the present invention, by forming at least one groove in an inlet side surface of the filtration unit, the filtration passages of the filter can be effectively prevented from being clogged.

Abstract: The present invention relates to novel compounds, to pharmaceutical compositions comprising the compounds described herein, their pharmaceutically acceptable salts, hydrates and solvates, as well as to the use of the compounds in medicine and for the preparation of a medicament which acts on the human 11-?-hydroxysteroid dehydrogenase type 1 enzyme (11?HSD1).

Abstract: Methods and systems for dynamically incorporating advertising content into multimedia environments, such as games, are provided. Example embodiments include a dynamic inserter, which selects content, based upon a set of criteria, to deliver to a receiving client system, such as a game client. The receiving client system typically dynamically determines locations within the game where advertisements are desirably inserted. Associated with these locations are ad tags that specify criteria for the ads including, for example ad type, ad genre, and scheduling information which are sent by the client system to the dynamic inserter to select appropriate ads. The dynamic inserter selects ads based upon the criteria and sends them to the client system, which selects them for ad tags with conforming criteria. The client system then renders the selected ad in the appropriate location.

Abstract: Methods and systems for dynamically incorporating advertising content into multimedia environments, such as games, are provided. Example embodiments include a dynamic inserter, which selects content, based upon a set of criteria, to deliver to a receiving client system, such as a game client. The receiving client system typically dynamically determines locations within the game where advertisements are desirably inserted. Associated with these locations are ad tags that specify criteria for the ads including, for example ad type, ad genre, and scheduling information which are sent by the client system to the dynamic inserter to select appropriate ads. The dynamic inserter selects ads based upon the criteria and sends them to the client system, which selects them for ad tags with conforming criteria. The client system then renders the selected ad in the appropriate location.

Abstract: Methods and systems for dynamically incorporating advertising content into multimedia environments, such as games, are provided. Example embodiments include a dynamic inserter, which selects content, based upon a set of criteria, to deliver to a receiving client system, such as a game client. The receiving client system typically dynamically determines locations within the game where advertisements are desirably inserted. Associated with these locations are ad tags that specify criteria for the ads including, for example ad type, ad genre, and scheduling information, which are sent by the client system to the dynamic inserter to select appropriate ads. The dynamic inserter selects ads based upon the criteria and sends them to the client system, which selects them for ad tags with conforming criteria. The client system then renders the selected ad in the appropriate location.

Abstract: A digital license is migrated from a source platform to a target platform. At the source platform, a migration image is produced to include the license and corresponding data therein, and the license is deleted from such source platform. At the target platform, permission is requested from a centralized migration service to migrate the license in the migration image to the target platform. The migration service determines whether to permit migration of the license based on predetermined migration policy. Upon receiving the requested permission as a response from the migration service, the migration image is applied to the target platform by un-tying the license from the source platform and re-tying the license to the target platform.

Abstract: A computing device has encrypted content and a corresponding license having a decryption key for decrypting the content. The license allows the computing device to render the content thereon. The computing device may issue a sub-license based on the license to a portable device. The sub-license allows the portable device to render the content thereon and has the decryption key. The portable device has a digital device certificate including information thereon. The computing device receives from the portable device the device certificate thereof, and determines based on rules in the license and the information on the portable device in the device certificate whether the computing device can issue the sub-license to the portable device. If so, the computing device constructs such sub-license to include the decryption key (KD) and transmits the constructed sub-license to the portable device.

Abstract: A method for storing data. A method for storing data comprising arranging a plurality of data buckets in a logical inverted tree structure having a plurality of levels; and performing nested hashing at each level of the plurality of levels.

Abstract: Generating a device certificate. A method of generating a device certificate comprising forming a template that will generate a device certificate upon the occurrence of a triggering event, filling in an authorization root certificate section of the template; filling in an authorization certificate section of the template, filling in a group certificate section of the template, and forming a device certificate section of the template.

Abstract: The present invention relates to compounds with the formula (I), or a pharmaceutically acceptable salt thereof: The invention also relates to pharmaceutical compositions comprising the compounds of formula (I) or formula (II) and methods of treating a condition that is mediated by the modulation of 11-?-hsd-1, the method comprising administering to a mammal an effective amount of a compound of formula (I) or formula (II).

Abstract: A strategy for semiautomatic sequencing of argentinated (silver-containing) oligopeptides is described. The method of sequencing described is based on a search algorithm that identifies a triplet peak relationship in a product ion spectrum of the [M+Ag]+ ion of an oligopeptide. The ions that constitute a triplet are [bn+OH+Ag]+, [bn−H+Ag]+, and [an−H+Ag]+, which are separated by 18 and 28 m/z units, respectively. The difference in the m/z values of adjacent triplets identifies the residue that is “cleaved”. Observation of the [yn+H+Ag]+ ion containing the cleaved residue confirms the assignment.