Abstract: The present invention provides compounds and methods of use thereof for assessing target engagement for DNA polymerase theta. In particular, provided herein are tracer compounds comprising a small molecule that binds DNA polymerase theta tethered to a fluorophore, and methods of use thereof in target engagement assays.

Abstract: In one embodiment, a computer-implemented method includes receiving, through a user interface (UI) of an artificial-reality (AR) design tool, a selection of a configurable interface element to place the AR design tool and the UI into a configure phase to configure an AR effect. The computer-implemented method further includes receiving, through the UI of the AR design tool after the AR design tool and the UI are placed into the configure phase in response to selecting the configurable interface element, instructions to add a voice-command module to the AR effect. The computer-implemented method further includes configuring, while the AR design tool and the UI are placed into the configure phase, one or more parameters of the voice-command module. The computer-implemented method further includes generating the AR effect utilizing a particular voice command at runtime based on configured one or more parameters of the voice-command module.

Abstract: Systems, methods, client devices, and non-transitory computer-readable media are disclosed for rendering custom video call interfaces having customizable video cells and/or interactive interface objects during a video call. For example, the disclosed systems can conduct a video call with one or more participant client devices through a streaming channel established for the video call. During the video call, the disclosed systems can render a video cell that portrays a video received from a participant client device in a grid-view display format. Subsequently, upon detecting a user interaction that indicates a request to customize a video call interface, the disclosed systems can render the video cell within a custom video call interface in a self-view display format. In some cases, the client device, via the self-view display format, facilitates various customizations and/or interactions with video cells and other interactive objects displayed on the client device during the video call.

Abstract: Systems, methods, client devices, and non-transitory computer-readable media are disclosed for utilizing video data and video processing data to enable shared augmented reality scenes having video textures depicting participants of video calls as augmented reality (AR) effects during the video calls. For instance, the disclosed systems can establish a video call between client devices that include streaming channels (e.g., a video and audio data channel). In one or more implementations, the disclosed systems enable the client devices to transmit video processing data and video data of a participant through the streaming channel during a video call. Indeed, in one or more embodiments, the disclosed systems cause the client devices to utilize video data streams and video processing data to render videos as video textures within AR effects in a shared AR scene (or AR space) of the video call (e.g., to depict participants within the AR scene).

Abstract: A computer-implemented method, comprising, by an artificial-reality (AR) design tool: receiving, through a user interface (UI) of the AR design tool, instructions to add a voice-command module to an AR effect, the voice-command module having an intent type and at least one slot, the slot associated with one or more entities; establishing, according to instructions received through the UI, a logical connection between the slot and a logic module configured to generate the AR effect depending on a runtime value associated with the slot; and generate, for the AR effect, an executable program configured to: determine that a detected utterance corresponds to the intent type and includes one or more words associated with the slot; select, based on the one or more words, one of the one or more entities as the runtime value for the slot; send the runtime value to the logic module according to the logical connection.

Abstract: Systems, methods, client devices, and non-transitory computer-readable media are disclosed for utilizing an augmented reality (AR) data channel to enable shared augmented reality video calls which facilitate the sharing of and interaction with AR elements during video calls. For example, the disclosed systems can establish a video call between client devices that include a video (and audio) data channel and an AR data channel. Moreover, in one or more embodiments, the disclosed systems enable one of the client devices to transmit AR data (e.g., AR element identifiers, AR elements, object vectors, participant identifiers) through an AR data channel to cause the other client device to render an AR element on a video captured by the other client device during a video call. Indeed, the disclosed systems can enable AR environments, AR effects, AR-based activities, and/or individual AR elements during a video call utilizing an AR data channel.

Abstract: A virtual reality (VR) system is described that enables users to create, model, and visualize augmented reality experiences at physical, real-world locations, without needing to physically be at the location for which the augmented experience is being modeled. In one example, the VR system includes a head-mounted device (HMD), an augmented reality content development system, and a rendering engine. The HMD is configured to output VR content representing a physical environment for an augmented reality experience. The augmented reality content development system is configured to identify, based on an input, augmented reality content with which to augment the physical environment for the augmented reality experience. The rendering engine is configured to render, via the HMD, the VR content representing the physical environment, augmented with the augmented reality content.

Abstract: One or more embodiments of the disclosure provide systems and methods for providing media presentations to users of a media presentation system. A media presentation generally includes a plurality of media segments provided by multiple users of the media presentation system. In one or more embodiments, a user of the media presentation system may share a media presentation with a co-user. The media presentation system can enable the co-user, if authorized by the user, to contribute (e.g., add a media segment) to a media presentation shared with the co-user.

Abstract: Examples include threat-aware copy data management. Responsive to a request to back up data, a threat level may be determined. Where the threat level is determined to be less than a threat level threshold, a data port between a first and second network domain may be opened. Conversely, the request may be denied where the threat level is determined to be at or greater than the threat level threshold.

Abstract: A computer-implemented method, comprising, by an artificial-reality (AR) design tool: receiving, through a user interface (UI) of the AR design tool, instructions to add a voice-command module to an AR effect, the voice-command module having an intent type and at least one slot, the slot associated with one or more entities; establishing, according to instructions received through the UI, a logical connection between the slot and a logic module configured to generate the AR effect depending on a runtime value associated with the slot; and generate, for the AR effect, an executable program configured to: determine that a detected utterance corresponds to the intent type and includes one or more words associated with the slot; select, based on the one or more words, one of the one or more entities as the runtime value for the slot; send the runtime value to the logic module according to the logical connection.

Abstract: One or more embodiments of the disclosure provide systems and methods for providing media presentations to users of a media presentation system. A media presentation generally includes a plurality of media segments provided by multiple users of the media presentation system. In one or more embodiments, a user of the media presentation system may share a media presentation with a co-user. The media presentation system can enable the co-user, if authorized by the user, to contribute (e.g., add a media segment) to a media presentation shared with the co-user.

Abstract: Aspects of the present disclosure are directed to three-dimensional (3D) video calls where at least some participants are assigned a position in a virtual 3D space. Additional aspects of the present disclosure are directed to an automated effects engine that can A) convert a source still image into a flythrough video; B) produce a transform video that replaces portions of a source video with an alternate visual effect; and/or C) produce a switch video that automatically matches frames between multiple source videos and stiches together the videos at the match points. Further aspects of the present disclosure are directed to a platform for the creation and deployment of automatic video effects that respond to lyric content and lyric timing values for audio associated with a video and/or that respond to beat types and beat timing values for audio associated with a video.

Abstract: The present invention provides novel methods and devices that employ microfluidic technology to generate molecular melt curves. In particular, the devices and methods in accordance with the invention are useful in providing for the analysis of PCR amplification products.

Abstract: In one embodiment, a method includes a computer machine reviewing a picture image and an associated video with the associated video including several video frames. The computer machine then statistically analyzes the corresponding areas for each video frame. The computer machine then compares an area in the picture image with an associated area in a video frame image, wherein the video frame image is based in part on the statistical analysis of the corresponding area for each video frame. Next, the computer machine creates an area for a composite image based in part on the comparison of the area in the picture image with the associated area in the video frame image.

Abstract: Described are methods and systems to provide an adaptive cognitive analytics platform to a user such that the user's data remains secure while enabling functionality adaptive to the user's needs. In some embodiments, a cognitive analytics application can be installed on the user's mobile device to analyze a plurality of data streams generated by sensors worn by the user. The cognitive analytics application is configured to allow the user to select and download one or more analytics programs from a plurality of vetted analytics programs depending on the user's desired functionality. The cognitive analytics application can be configured to determine the types of analytics program usable by the user based on the data streams available at the user's mobile device. To secure user data and protect the user's data privacy, the cognitive analytics application can prevent the plurality of analytics programs from transmitting monitored physiological data.

Abstract: In one embodiment, a method for designing an augmented-reality effect may include displaying a virtual object in a 3D space of a user interface comprising a first and second display areas, wherein the virtual object is displayed from a first perspective in the first display area and displayed from a second perspective in the second display area, the second perspective being different from the first perspective, receiving, via the user interface, instructions to adjust the virtual object, adjusting the virtual object according to the instructions, and displaying the adjusted virtual object in the 3D space of the user interface, wherein the adjusted virtual object is displayed from the first perspective in the first display area and displayed from the second perspective in the second display area.

Abstract: The present invention provides novel methods and devices that employ microfluidic technology to generate molecular melt curves. In particular, the devices and methods in accordance with the invention are useful in providing for the analysis of PCR amplification products.

Abstract: Disclosed herein is composite for the cathode of Li-ion battery comprising: a first component and a second component represented by LiNi0.5Mn1.5O2; wherein the first component contains active material or surface treated active material, wherein the active material is represented by a formula Li1+a(Ni1?b?cCobMnc)O2, 0?a?0.5, 0?b?0.4, 0?c?0.6, with b+c<1; based on the total amount of the composite, the content of the second component is 1 wt % to 30 wt %. Also disclosed herein is a Li-ion battery comprising a cathode, an anode and a separator sandwiched therebetween, wherein the cathode contains the above mentioned composite. The present disclosure provides a cathode material for Li-ion batteries with greater high voltage stability, high voltage capacity retention, high energy density and greater cycle life than the existing material.

Abstract: In one embodiment, a method includes by a computing device, displaying a user interface for designing augmented-reality effects. The method includes receiving user input through the user interface. The method includes displaying a graph generated based on the user input. The graph may include multiple nodes and one or more edges. The nodes may include a detector node and a filter node connected by one or more edges. The method includes detecting, in accordance with an object type specified by the detector node, one or more object instances of the object type appearing in a scene. The method includes selecting, in accordance with at least one criterion specified by the filter node, at least one of the one or more detected object instances that satisfies the criterion. The method includes rendering an augmented-reality effect based on at least the selected object instance.