Abstract: A monitoring appliance for a data storage array used by plural hosts to store data responds to stored metadata to interrogate the data storage array at intervals to establish the amount of usage of the data storage array. Each host can use the file system(s) and/or database(s) of its choice in portions of the data storage array allocated to it. The monitoring appliance has basic knowledge of all file systems/databases used by the hosts, and the metadata structure of those file systems/databases.

Abstract: A number of virtual areas with virtual addresses of storage locations within the virtual areas are allocated to a data storage array, having a total physical storage capacity. Physical addresses are allocated by an array controller for the disc storage array to the virtual addresses only as data are to be written to the respective virtual addresses.

Abstract: A tape drive assembly for performing a backup operation has a tape receiving station to receive a data storage unit including a tape to store data in a data backup operation. A write head writes data to the tape in a data backup operation. A non-volatile memory unit records data in a data backup operation and communicates data to the write head. An input connected to a data host machine passes data to the memory unit such that, in use in a data backup operation, the data are communicated from the data host machine to the input and recorded in the memory unit prior to the data being passed from the memory unit to the write head for writing to the tape.

Abstract: Antibody Directed Enzyme Prodrug Therapy (ADEPT) systems for use in cancer based on mutated carboxypeptidase B (CPB) enzymes. Enzyme conjugates for ADEPT are substantially non-immunogenic in humans comprising a targeting moiety (for example an antibody) capable of binding with a tumor associated antigen, the targeting moiety being linked to a mutated form of a CPB enzyme capable of converting a prodrug into an antineoplastic drug wherein the prodrug is not significantly convertible into antineoplastic drug in humans by natural unmutated enzyme. A preferred enzyme mutant is human pancreatic CPB comprising a Lys or Arg residue at position 253. Suitable mustard prodrugs are disclosed in the specification.

Abstract: Methods, apparatus, and systems for optimized digital photo management include an optimized digital photo management user interface, referred to as the photo-journal UI (PJUI), a client application with a photo-journal UI for general purpose personal computers (of any form factor), referred to as a photo-journal application, a dedicated portable client device with a small-screen optimized photo-journal UI, referred to as a photo-tablet, and a companion server for either photo-journal client platform, referred to as a tablet-server. Thus, the photo-tablet and the photo-journal application are alternative photo-journal client embodiments with different variations of the same photo-journal user interface architecture. The photo-tablet is designed to be an intermittently connected Internet-appliance. In the photo-tablet, the small-screen optimized PJUI runs entirely on the photo-tablet, even for actions involving the server.

Abstract: A plurality of computers in a network (503-505) each have a processor and a non-volatile data storage device (500-502) such as a hard disk, a raid array, or the like. Each data storage device is divided into a first data storage area (203-205) and a second data storage area (509-511). The first data storage area is reserved for use by at least one processor to which it is assigned, whereas the second data storage area is hidden from use by the file system of the computer, and is used to store replicated data of other ones of the plurality of computer entities. In the event of failure of any one of the data storage devices, data can be recovered from the second data storage areas of the other data storage devices.

Abstract: A data storage tape 4 has an associated memory device 3 in which is stored a number of signatures 12 each representative of and associated with a particular data set recorded on the storage medium. By comparing the signatures against either signatures created during reading of the data sets back from the tape or against reference information held on a secure database any tampering or alteration of the data on the storage medium can be detected.

Abstract: A plurality of computers in a network (503-505) each have a processor and a non-volatile data storage device (500-502) such as a hard disk, a raid array, or the like. Each data storage device is divided into a first data storage area (203-205) and a second data storage area (509-511). The first data storage area is reserved for use by at least one processor to which it is assigned, whereas the second data storage area is hidden from use by the file system of the computer, and is used to store replicated data of other ones of the plurality of computer entities. In the event of failure of any one of the data storage devices, data can be recovered from the second data storage areas of the other data storage devices.

Abstract: A two component system for therapeutic treatment of a host, having a first component comprising a targeting moiety capable of binding with a tumour associated antigen, linked to a mutated enzyme capable of converting a prodrug into an antineoplastic drug, and a second component comprising a prodrug convertible under the influence of the mutated enzyme to the antineoplastic drug. The mutated enzyme is a mutated form of a natural host enzyme which recognizes its natural substrate by an ion pair interaction with the substrate, wherein the mutated enzyme and prodrug have structures such that the polarity of the mutated enzyme/prodrug ion pair interaction is reversed relative to the natural host enzyme/natural substrate ion pair interaction. The first component is substantially non-immunogenic in the host and the prodrug second component is not significantly convertible into antineoplastic drug in the host by natural unmutated host enzyme.

Abstract: An intelligent alarm system includes exit sign units having couplings to a smoke sensor and heat sensor for input information, a speech synthesizer and a strobe light to provide output information and a communication unit to provide communication coupling between exit sign units on a single floor and between interfloor interfaces and a central monitoring unit. The exit sign units provide at least two indications to the occupants. First a strobe light to flash at exits with sufficient intensity to draw attention to the exit and to penetrate smoke in a smoke filled hallway. Second, a speech synthesizer which provides verbal instructions to floor occupants according to the emergency situation. Each exit sign unit is operative independently of the central monitoring unit to set off a local alarm.