Abstract: Diagnostic immunoassay reagent compositions are disclosed that include liposomes having analyte-specific binding element(s) associated therewith. In particular, the analyte-specific binding element(s) includes a transmembrane domain that anchors the element(s) in the lipid bilayer of the liposome; the analyte-specific binding element(s) further includes an extracellular/extra membrane domain that is exposed on the outer surface of the liposome and that comprises a domain that specifically binds to the target analyte. Also disclosed are kits, devices, and systems that contain the diagnostic immunoassay reagent compositions, as well as methods of producing and using the diagnostic immunoassay reagent compositions.

Abstract: An actuating apparatus for controlling a locking system of a motor vehicle, including a circuit arrangement having a first input for receiving an operating signal and an output for providing a control signal to the locking system, the control signal being generated in dependence on the operating signal. The actuating apparatus further comprises a manually operated emergency unlocking device, and the circuit arrangement comprises a second input for receiving an event signal, wherein upon receipt of the event signal the manually operated emergency unlocking device is enabled for manual operation.

Abstract: The present disclosure relates to an acoustic signal generating device for a medical injection device. The acoustic signal generating device has a base body comprising a first resilient arm comprising a first free end; an abutment surface, and an impact surface. The first resilient arm is configured to be deflected by a first load being applied on the first resilient arm such that the first free end of the first resilient arm is in compressive engagement with the abutment surface, whereby when the first load is increased to a second load the first free end is released from compressive engagement with the abutment surface and the first resilient arm hits the impact surface, thereby generating an acoustic signal. Moreover, the present disclosure relates to a medical injection device comprising said acoustic signal generating device.

Abstract: A medical injection device comprises a housing having a retaining portion, an actuating element movably arranged in the housing, and a resilient element movably arranged in the housing. In an initial state of the medical injection device the resilient element is pretensioned. The resilient element comprises an actuating portion; an impacting portion, and an abutment portion which in the initial state is in compressive engagement with the retaining portion. The resilient element is configured to be displaced relative to the housing by a displacement of the actuating element against the actuating portion such that the abutment portion disengages from engagement with the retaining portion, whereby the tension of the pretensioned resilient element causes the impacting portion to hit an impact receiving portion of the medical injection device, thereby generating an acoustic signal.

Abstract: A needle safety device comprises (a) an elongated hub portion with a longitudinal axis that comprises a cannula, (b) a tubular protection element that is movable along the longitudinal axis relative to the hub portion, wherein the protection element comprises a contact surface for establishing pressure contact with an injection area, (c) a tubular separable element comprising at least two locking parts and (d) a spring element which biases the protection element such that the contact surface is further spaced apart from the hub portion along the longitudinal axis than the tip of the cannula. The protection element is configured to move into an injection position, wherein the separable element separates into the locking parts when the contact surface is released from contact with the injection area. The separated locking parts block the protection element from returning into the injection position when the protection element has moved to a final position.

Abstract: A needle safety device comprises an elongated hub portion having a longitudinal axis. The hub portion comprises a cannula and a guide pin extending outward from the hub portion. Further, the needle safety device comprises a first tubular element movably arranged on the hub portion to move along the longitudinal axis. The first tubular element comprises a guide track slidably engaging with the guide pin. The guide track is configured such that the first tubular element rotates relative to the hub portion when the guide pin moves along the guide track. The guide track has a final position to immovably retain the guide pin. Further, the needle safety device comprises a second tubular element arranged on the first tubular element such that it is movable along the longitudinal axis with the first tubular element. The first tubular element is at least partially enclosed by the second tubular element.

Abstract: A profiled clamp for assembling on pipe ends, having a first half-shell and a second half-shell, each of which has a clamping head at a first end and a connection geometry at a second end for releasably connecting the second end. The clamping heads are connected to a clamping element, and at least one of the two half-shells can be tilted relative to the clamping element. A spring element is arranged in the region of the clamping heads, said spring element pushing the second ends of the half-shells apart under pretension. Contact regions of the spring element can be positioned on the pipe ends in a frictionally locking manner when connecting the two ends.

Abstract: An actuating apparatus for controlling a locking system of a motor vehicle, including a circuit arrangement having a first input for receiving an operating signal and an output for providing a control signal to the locking system, the control signal being generated in dependence on the operating signal. The actuating apparatus further comprises a manually operated emergency unlocking device, and the circuit arrangement comprises a second input for receiving an event signal, wherein upon receipt of the event signal the manually operated emergency unlocking device is enabled for manual operation.

Abstract: The disclosure relates to a spring clamp, having a clamp band and a positioning device for pre-positioning the spring clamp on a hose end of a hose. The positioning device having a support band and a contact region, and the support band having. The positioner having a fixing means arranged at the end of the support band, and the support band having a retainer at another end of the support band. A web is formed in the support band between the contact region and the positioner. The support band has at least two regions in the region of the positioner, the first region extending from the web away from the clamp band and the second region extending substantially perpendicularly from the first region.

Abstract: A vinyl amine containing polymer comprises randomly distributed repeating monomer units having at least two of the following formulae: wherein, R1 is a hydrogen atom or a methyl group; and wherein the vinyl amine containing polymer comprises repeating monomer unit III and/or IV in a total amount of from about 1.5 weight percent to about 8 weight percent based on a total weight of the polymer.

Abstract: An optical sensor device configured to detect a time of flight of an electromagnetic signal includes a semiconductor substrate having a main surface and a conversion region configured to convert at least a fraction of the electromagnetic signal into photo-generated charge carriers; a first control electrode formed in a trench extending from the main surface into the semiconductor substrate; a second control electrode disposed directly or indirectly on the main surface; a control circuit configured to apply a varying first potential to the first control electrode and to apply a varying second potential to the second control electrode, where the varying second potential has a fixed phase relationship to the first varying potential, to generate electric potential distributions in the conversion region to direct the photo-generated charge carriers; and a readout node arranged in the semiconductor substrate and configured to detect the directed photo-generated charge carriers.

Abstract: A profiled clamp for assembling on pipe ends, having a first half-shell and a second half-shell, each of which has a clamping head at a first end and a connection geometry at a second end for releasably connecting the second end. The clamping heads are connected to a clamping element, and at least one of the two half-shells can be tilted relative to the clamping element. A spring element is arranged in the region of the clamping heads, said spring element pushing the second ends of the half-shells apart under pretension. Contact regions of the spring element can be positioned on the pipe ends in a frictionally locking manner when connecting the two ends.

Abstract: The disclosure relates to a spring clamp, having a clamp band and a positioning device for pre-positioning the spring clamp on a hose end of a hose. The positioning device having a support band and a contact region, and the support band having. The positioner having a fixing means arranged at the end of the support band, and the support band having a retainer at another end of the support band. A web is formed in the support band between the contact region and the positioner. The support band has at least two regions in the region of the positioner, the first region extending from the web away from the clamp band and the second region extending substantially perpendicularly from the first region.

Abstract: An optical sensor device configured to detect a time of flight of an electromagnetic signal includes a semiconductor substrate having a main surface and a conversion region configured to convert at least a fraction of the electromagnetic signal into photo-generated charge carriers; a first control electrode formed in a trench extending from the main surface into the semiconductor substrate; a second control electrode disposed directly or indirectly on the main surface; a control circuit configured to apply a varying first potential to the first control electrode and to apply a varying second potential to the second control electrode, where the varying second potential has a fixed phase relationship to the first varying potential, to generate electric potential distributions in the conversion region to direct the photo-generated charge carriers; and a readout node arranged in the semiconductor substrate and configured to detect the directed photo-generated charge carriers.

Abstract: An optical sensor device configured to detect a time of flight of an electromagnetic signal includes a semiconductor substrate with a conversion region configured to convert at least a portion of the electromagnetic signal into photo-generated charge carriers. A deep control electrode is formed in a trench extending into the semiconductor substrate. The deep control electrode extends deeper into the semiconductor substrate than a shallow control electrode. A control circuit is configured to apply to the deep control electrode and to the shallow control electrode varying potentials having a fixed phase relationship to each other, to generate electric potential distributions in the conversion region, by which the photo-generated charge carriers in the conversion region are directed. The directed photo-generated charge carriers are detected at at least one readout node.

Abstract: The invention relates to a clamp (1), in particular for fastening tubular objects to an underlying surface, comprising a clamp band (2), which has a first peripheral end (3) having a first leg (4) and a second peripheral end (5) having a second leg (6), and comprising at least one clip (7, 71), which is arranged on at least one of the legs (4, 6) on a side opposite the other leg (6, 4). The problem addressed by the invention is that of designing such a clamp in a simple manner and provide said clamp economically. This problem is solved in that the clamp band (2) has at least one projection (21), which interacts with the at least one clip (7, 71).

Abstract: The present invention provides a time-of-flight sensor (22) including at least one time-of-flight pixel (23) for demodulating a received modulated light beam (Sp2), wherein the time-of-flight pixel (23) comprises at least two integrating nodes (Ga, Gb) and the integration nodes (Ga, Gb) are connected to a device (500) for charge compensation, wherein the charge compensation device (500) comprises at least two SBI input transistors (M1, M2) which at a potential (Ua, Ub) of the integration nodes (Ga, Gb) which according to the amount exceeds an SBI threshold value (USBI) drive SBI current transistors (M3, M4) such that at both integration nodes (Ga, Gb) a compensating current (ik) of the same level flows, wherein the source terminals of the SBI-current transistors (M3, M4) are not connected to a supply voltage (UDD) but are connected to a working voltage (URES, Uarb) (FIG. 7).

Abstract: The disclosure relates to a clamp (1), comprising a clamp band (2) extending in a peripheral direction (U) and a tensioning device (7) for tensioning the clamp band (2). According to an embodiment, in order to form the clamp (1) with yielding properties during tensioning and from a minimal number of structural components, the clamp band (2) has structures (11, 12) that extend at the edges (5, 6) of the clamp band.

Abstract: An optical sensor device configured to detect a time of flight of an electromagnetic signal includes a semiconductor substrate with a conversion region configured to convert at least a portion of the electromagnetic signal into photo-generated charge carriers. A deep control electrode is formed in a trench extending into the semiconductor substrate. The deep control electrode extends deeper into the semiconductor substrate than a shallow control electrode. A control circuit is configured to apply to the deep control electrode and to the shallow control electrode varying potentials having a fixed phase relationship to each other, to generate electric potential distributions in the conversion region, by which the photo-generated charge carriers in the conversion region are directed. The directed photo-generated charge carriers are detected at at least one readout node.

Abstract: The present invention provides a time-of-flight sensor (22) including at least one time-of-flight pixel (23) for demodulating a received modulated light beam (Sp2), wherein the time-of-flight pixel (23) comprises at least two integrating nodes (Ga, Gb) and the integration nodes (Ga, Gb) are connected to a device (500) for charge compensation, wherein the charge compensation device (500) comprises at least two SBI input transistors (M1, M2) which at a potential (Ua, Ub) of the integration nodes (Ga, Gb) which according to the amount exceeds an SBI threshold value (USBI) drive SBI current transistors (M3, M4) such that at both integration nodes (Ga, Gb) a compensating current (ik) of the same level flows, wherein the source terminals of the SBI-current transistors (M3, M4) are not connected to a supply voltage (UDD) but are connected to a working voltage (URES, Uarb) (FIG. 7).