Patents by Inventor Michael Sonntag
Michael Sonntag has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 12138348Abstract: The present invention is directed to a storage-stable formulation of long-chain RNA. In particular, the invention concerns a dry powder composition comprising a long-chain RNA molecule. The present invention is furthermore directed to methods for preparing a dry powder composition comprising a long-chain RNA molecule by spray-freeze drying. The invention further concerns the use of such a dry powder composition comprising a long-chain RNA molecule in the preparation of pharmaceutical compositions and vaccines, to a method of treating or preventing a disorder or a disease, to first and second medical uses of such a dry powder composition comprising a long-chain RNA molecule and to kits, particularly to kits of parts, comprising such a dry powder composition comprising a long-chain RNA molecule.Type: GrantFiled: February 21, 2022Date of Patent: November 12, 2024Assignee: CureVac SEInventors: Fabian Johannes Eber, Benyamin Yazdan Panah, Stefanie Sewing, Thomas Ketterer, Thorsten Mutzke, Tilmann Roos, Michael Sonntag, Michael Wiggenhorn, Katharina Kolland
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Publication number: 20240342206Abstract: The present invention relates to mRNA medicines for use in the therapy and prevention of liver diseases like liver fibrosis, liver cirrhosis, hepatocellular carcinoma (HCC), non-alcoholic fatty liver disease (NAFLD), non-alcoholic steatohepatitis (NASH) or liver cancer, and more particularly to mRNA medicines of this kind which can exhibit excellent therapeutic and preventive effects with respect to liver diseases individually developed or to complications resulting from diseases of these organs. In detail, the present invention relates to an mRNA suitable for treatment or prophylaxis of liver diseases. In particular, the present invention provides mRNAs encoding hepatocyte nuclear factor 4 alpha (HNF4A), human wild type and engineered variants thereof), or a fragment or a variant of any of these peptides or proteins. The present invention concerns said mRNA as well as compositions and kits comprising the mRNA.Type: ApplicationFiled: July 29, 2022Publication date: October 17, 2024Applicant: CureVac SEInventors: Tim SONNTAG, Marion PÖNISCH, Frédéric CHEVESSIER-TÜNNESEN, Michael OTT, Amar DEEP SHARMA
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Patent number: 12103126Abstract: A suction adapter, in particular a suction drill suction adapter, for connecting an insertion tool, in particular a suction drill, to a suction apparatus includes at least one insertion tool receiving region, in which the insertion tool is arranged, at least one connection interface with respect to an insertion tool suction channel of the insertion tool, and at least one, in particular dimensionally stable, discharge guiding unit configured to delimit a suction channel. The at least one discharge guiding unit has at least one discharge guiding element configured to delimit a suction channel outlet of the suction channel and which has a longitudinal axis. The longitudinal axis of the at least one discharge guiding element is orientated parallel with a main extent axis of the at least one insertion tool receiving region in a region of the suction channel outlet in at least one operating state.Type: GrantFiled: June 25, 2021Date of Patent: October 1, 2024Assignee: Robert Bosch GmbHInventors: Andreas Schurig, Edit Okenwa, Fritz Schlegel, Hardy Schmid, Holger Froehling, Michael Briesenick, Stefan Sonntag, Tamara Gaschler
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Publication number: 20240299309Abstract: The invention is inter alia directed to a pharmaceutical composition or vaccine for multidose administration comprising lipid-based carriers encapsulating an RNA, wherein the composition comprises at least one antimicrobial preservative selected from an aromatic alcohol, a sugar alcohol, thiomersal, or a combination thereof. The present invention is also directed to a kit or kit of parts for preparing and/or administering the pharmaceutical composition or vaccine for multidose administration. Also provided are methods of treating or preventing a disorders or a diseases, and first and second medical uses of the pharmaceutical composition or vaccine. Further provided is the use of aromatic alcohols, sugar alcohols, and/or thiomersal for preserving and/or preparing a composition or vaccine comprising lipid-based carriers encapsulating an RNA.Type: ApplicationFiled: December 13, 2021Publication date: September 12, 2024Applicant: CureVac SEInventors: Michael SONNTAG, Tilmann ROOS, Stefan ARNOLD, Christoph ERBACHER
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Publication number: 20240238402Abstract: The present invention relates to a method for producing a liquid composition comprising a nanoparticle comprising at least one RNA and at least one cationic or polycationic compound, advantageously on a large scale suitable for pharmaceutical applications. The present invention further concerns the use of the inventive method in the manufacture of a medicament or a vaccine. Furthermore, the invention relates to compositions containing the RNA-comprising nanoparticle, and to pharmaceutical compositions comprising the same.Type: ApplicationFiled: July 10, 2023Publication date: July 18, 2024Applicant: CureVac Manufacturing GmbHInventors: Thorsten MUTZKE, Markus KREUZ, Stefanie SEWING, Fabian Johannes EBER, Wenke WAGNER, Michael SONNTAG, Michael WIGGENHORN, Katharina KOLLAND
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Publication number: 20230288198Abstract: A sensor unit comprising an electronics unit, a first housing part and a second housing part connected thereto is provided. The first and second housing parts form an interior between them and, directed away therefrom, each of them has a housing part outer side. The electronics unit is connected to the first housing part and projects into the interior, wherein a contact area passing through the first housing part is provided. The electronics unit has at least one circuit board with at least two circuit board portions connected to one another in an electrically conductive manner, wherein a first circuit board portion is arranged between the contact area and a second circuit board portion in an electrically conductive manner.Type: ApplicationFiled: January 30, 2023Publication date: September 14, 2023Inventors: Michael Sonntag, Michael Prinz
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Patent number: 11744886Abstract: The present invention relates to a method for producing a liquid composition comprising a nanoparticle comprising at least one RNA and at least one cationic or polycationic compound, advantageously on a large scale suitable for pharmaceutical applications. The present invention further concerns the use of the inventive method in the manufacture of a medicament or a vaccine. Furthermore, the invention relates to compositions containing the RNA-comprising nanoparticle, and to pharmaceutical compositions comprising the same.Type: GrantFiled: April 2, 2020Date of Patent: September 5, 2023Assignee: CureVac Manufacturing GmbHInventors: Thorsten Mutzke, Markus Kreuz, Stefanie Sewing, Fabian Johannes Eber, Wenke Wagner, Michael Sonntag, Michael Wiggenhorn, Katharina Kolland
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Patent number: 11534405Abstract: The present invention is directed to a storage-stable formulation of long-chain RNA. In particular, the invention concerns a dry powder composition comprising a long-chain RNA molecule. The present invention is furthermore directed to methods for preparing a dry powder composition comprising a long-chain RNA molecule by spray-freeze drying. The invention further concerns the use of such a dry powder composition comprising a long-chain RNA molecule in the preparation of pharmaceutical compositions and vaccines, to a method of treating or preventing a disorder or a disease, to first and second medical uses of such a dry powder composition comprising a long-chain RNA molecule and to kits, particularly to kits of parts, comprising such a dry powder composition comprising a long-chain RNA molecule.Type: GrantFiled: June 18, 2020Date of Patent: December 27, 2022Assignee: CureVac AGInventors: Fabian Johannes Eber, Benyamin Yazdan Panah, Stefanie Sewing, Thomas Ketterer, Thorsten Mutzke, Tilmann Roos, Michael Sonntag, Michael Wiggenhorn, Katharina Kolland
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Publication number: 20220387320Abstract: The present invention is directed to a storage-stable formulation of long-chain RNA. In particular, the invention concerns a dry powder composition comprising a long-chain RNA molecule. The present invention is furthermore directed to methods for preparing a dry powder composition comprising a long-chain RNA molecule by spray-drying. The invention further concerns the use of such a dry powder composition comprising a long-chain RNA molecule in the preparation of pharmaceutical compositions and vaccines, to a method of treating or preventing a disorder or a disease, to first and second medical uses of such a dry powder composition comprising a long-chain RNA molecule and to kits, particularly to kits of parts, comprising such a dry powder composition comprising a long-chain RNA molecule.Type: ApplicationFiled: July 11, 2022Publication date: December 8, 2022Applicant: CureVac AGInventors: Fabian Johannes EBER, Benyamin YAZDAN PANAH, Stefanie SEWING, Thomas KETTERER, Thorsten MUTZKE, Tilmann ROOS, Michael SONNTAG, Michael WIGGENHORN, Katharina KOLLAND
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Publication number: 20220387728Abstract: A cover assembly that covers a medicament delivery member of a medicament container. The assembly having a housing extending along a longitudinal axis, a proximal end and a distal end. A cover member bi-directionally movable along the longitudinal axis relative to the housing, where the cover member has a tubular portion arranged to protrude from the proximal end of the housing, a biasing element arranged between the housing and the cover member configured to move the cover member, a locking member having a fixed end which is pivotally arranged to the housing and a free end which is releasably connected to the cover member. The cover assembly also has an actuator unit connected to the housing configured to interact with the free end of the locking member such that the locking member is able to lock and unlock the cover member in different positions.Type: ApplicationFiled: October 29, 2020Publication date: December 8, 2022Inventors: Hsuan Wang, Jared Schwartzentruber, Yun-Ting Lee, Michael Sonntag, Slobodan Stefanov, Frederick Gertz
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Publication number: 20220347395Abstract: A delivery member shield remover assembly is presented that includes a housing which extends along a longitudinal axis L and which has a proximal and a distal end; and a delivery member shield remover having a free end and a fixed end and wherein said delivery member shield remover is resiliently connected to the housing, wherein the fixed end is connected to the housing and the free end of the delivery member shield remover is configured to be positioned in a gap defined between the medicament container and the delivery member shield such that a distal movement of the movable medicament container in relation to the housing, forces the free end of the delivery member shield remover to move in a distal direction until the delivery member shield remover reaches a bias threshold and forces the delivery member shield to detach from the movable medicament container.Type: ApplicationFiled: August 10, 2020Publication date: November 3, 2022Inventors: Michael Sonntag, Jared Schwartzentruber
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Patent number: 11433027Abstract: The present invention is directed to a storage-stable formulation of long-chain RNA. In particular, the invention concerns a dry powder composition comprising a long-chain RNA molecule. The present invention is furthermore directed to methods for preparing a dry powder composition comprising a long-chain RNA molecule by spray-drying. The invention further concerns the use of such a dry powder composition comprising a long-chain RNA molecule in the preparation of pharmaceutical compositions and vaccines, to a method of treating or preventing a disorder or a disease, to first and second medical uses of such a dry powder composition comprising a long-chain RNA molecule and to kits, particularly to kits of parts, comprising such a dry powder composition comprising a long-chain RNA molecule.Type: GrantFiled: August 20, 2020Date of Patent: September 6, 2022Assignee: CureVac AGInventors: Fabian Johannes Eber, Benyamin Yazdan Panah, Stefanie Sewing, Thomas Ketterer, Thorsten Mutzke, Tilmann Roos, Michael Sonntag, Michael Wiggenhorn, Katharina Kolland
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Publication number: 20220168225Abstract: The present invention is directed to a storage-stable formulation of long-chain RNA. In particular, the invention concerns a dry powder composition comprising a long-chain RNA molecule. The present invention is furthermore directed to methods for preparing a dry powder composition comprising a long-chain RNA molecule by spray-freeze drying. The invention further concerns the use of such a dry powder composition comprising a long-chain RNA molecule in the preparation of pharmaceutical compositions and vaccines, to a method of treating or preventing a disorder or a disease, to first and second medical uses of such a dry powder composition comprising a long-chain RNA molecule and to kits, particularly to kits of parts, comprising such a dry powder composition comprising a long-chain RNA molecule.Type: ApplicationFiled: February 21, 2022Publication date: June 2, 2022Applicant: CureVac AGInventors: Fabian Johannes EBER, Benyamin YAZDAN PANAH, Stefanie SEWING, Thomas KETTERER, Thorsten MUTZKE, Tilmann ROOS, Michael SONNTAG, Michael WIGGENHORN, Katharina KOLLAND
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Patent number: 11179337Abstract: The present invention is directed to a storage-stable formulation of long-chain RNA. In particular, the invention concerns a dry powder composition comprising a long-chain RNA molecule. The present invention is furthermore directed to methods for preparing a dry powder composition comprising a long-chain RNA molecule by spray-drying. The invention further concerns the use of such a dry powder composition comprising a long-chain RNA molecule in the preparation of pharmaceutical compositions and vaccines, to a method of treating or preventing a disorder or a disease, to first and second medical uses of such a dry powder composition comprising a long-chain RNA molecule and to kits, particularly to kits of parts, comprising such a dry powder composition comprising a long-chain RNA molecule.Type: GrantFiled: November 11, 2019Date of Patent: November 23, 2021Assignee: CureVac AGInventors: Fabian Johannes Eber, Benyamin Yazdan Panah, Stefanie Sewing, Thomas Ketterer, Thorsten Mutzke, Tilmann Roos, Michael Sonntag, Michael Wiggenhorn, Katharina Kolland
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Publication number: 20210030683Abstract: The present invention is directed to a storage-stable formulation of long-chain RNA. In particular, the invention concerns a dry powder composition comprising a long-chain RNA molecule. The present invention is furthermore directed to methods for preparing a dry powder composition comprising a long-chain RNA molecule by spray-freeze drying. The invention further concerns the use of such a dry powder composition comprising a long-chain RNA molecule in the preparation of pharmaceutical compositions and vaccines, to a method of treating or preventing a disorder or a disease, to first and second medical uses of such a dry powder composition comprising a long-chain RNA molecule and to kits, particularly to kits of parts, comprising such a dry powder composition comprising a long-chain RNA molecule.Type: ApplicationFiled: June 18, 2020Publication date: February 4, 2021Applicant: CureVac AGInventors: Fabian Johannes EBER, Benyamin YAZDAN PANAH, Stefanie SEWING, Thomas KETTERER, Thorsten MUTZKE, Tilmann ROOS, Michael SONNTAG, Michael WIGGENHORN, Katharina KOLLAND
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Publication number: 20200383919Abstract: The present invention is directed to a storage-stable formulation of long-chain RNA. In particular, the invention concerns a dry powder composition comprising a long-chain RNA molecule. The present invention is furthermore directed to methods for preparing a dry powder composition comprising a long-chain RNA molecule by spray-drying. The invention further concerns the use of such a dry powder composition comprising a long-chain RNA molecule in the preparation of pharmaceutical compositions and vaccines, to a method of treating or preventing a disorder or a disease, to first and second medical uses of such a dry powder composition comprising a long-chain RNA molecule and to kits, particularly to kits of parts, comprising such a dry powder composition comprising a long-chain RNA molecule.Type: ApplicationFiled: August 20, 2020Publication date: December 10, 2020Applicant: CureVac AGInventors: Fabian Johannes EBER, Benyamin YAZDAN PANAH, Stefanie SEWING, Thomas KETTERER, Thorsten MUTZKE, Tilmann ROOS, Michael SONNTAG, Michael WIGGENHORN, Katharina KOLLAND
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Publication number: 20200246451Abstract: The present invention relates to a method for producing a liquid composition comprising a nanoparticle comprising at least one RNA and at least one cationic or polycationic compound, advantageously on a large scale suitable for pharmaceutical applications. The present invention further concerns the use of the inventive method in the manufacture of a medicament or a vaccine. Furthermore, the invention relates to compositions containing the RNA-comprising nanoparticle, and to pharmaceutical compositions comprising the same.Type: ApplicationFiled: April 2, 2020Publication date: August 6, 2020Applicant: CureVac Real Estate GmbHInventors: Thorsten MUTZKE, Markus KREUZ, Stefanie SEWING, Fabian Johannes EBER, Wenke WAGNER, Michael SONNTAG, Michael WIGGENHORN, Katharina KOLLAND
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Patent number: 10729654Abstract: The present invention is directed to a storage-stable formulation of long-chain RNA. In particular, the invention concerns a dry powder composition comprising a long-chain RNA molecule. The present invention is furthermore directed to methods for preparing a dry powder composition comprising a long-chain RNA molecule by spray-freeze drying. The invention further concerns the use of such a dry powder composition comprising a long-chain RNA molecule in the preparation of pharmaceutical compositions and vaccines, to a method of treating or preventing a disorder or a disease, to first and second medical uses of such a dry powder composition comprising a long-chain RNA molecule and to kits, particularly to kits of parts, comprising such a dry powder composition comprising a long-chain RNA molecule.Type: GrantFiled: May 20, 2016Date of Patent: August 4, 2020Assignee: CureVac AGInventors: Fabian Johannes Eber, Benyamin Yazdan Panah, Stefanie Sewing, Thomas Ketterer, Thorsten Mutzke, Tilmann Roos, Michael Sonntag, Michael Wiggenhorn, Katharina Kolland
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Patent number: 10696068Abstract: Rotary table digital printing machine for printing on work pieces, including at least one workstation attached to a holding frame, which is designed as a printing unit for printing on work pieces and includes a support frame for receiving an inking unit and a print head module, the support frame including a printing unit interface for coupling with a printing unit receptacle associated with the holding frame and further including a print head interface designed for coupling with a print head module, with a print head module and with an inking unit adapted to provide a printing ink to the print head module, a print head carrier having a carrier interface adapted to be coupled to the print head interface, wherein the printing unit receptacle, the printing unit interface, the inking unit, the print head interface, the carrier interface and the print head module form a row arrangement arranged along the printing direction.Type: GrantFiled: October 2, 2018Date of Patent: June 30, 2020Assignee: HINTERKOPF GMBHInventors: Joachim Weber, Joachim Schulz, Michael Sonntag, Florian Goller
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Patent number: 10653768Abstract: The present invention relates to a method for producing a liquid composition comprising a nanoparticle comprising at least one RNA and at least one cationic or polycationic compound, advantageously on a large scale suitable for pharmaceutical applications. The present invention further concerns the use of the inventive method in the manufacture of a medicament or a vaccine. Furthermore, the invention relates to compositions containing the RNA-comprising nanoparticle, and to pharmaceutical compositions comprising the same.Type: GrantFiled: April 13, 2016Date of Patent: May 19, 2020Assignee: CureVac Real Estate GmbHInventors: Thorsten Mutzke, Markus Kreuz, Stefanie Sewing, Fabian Johannes Eber, Wenke Wagner, Michael Sonntag, Michael Wiggenhorn, Katharina Kolland