Patents by Inventor Michael Spinella

Michael Spinella has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for determining sensitivity to decitabine treatment
    Patent number: 9476099
    Abstract: The present invention is a gene expression panel of chemotherapeutic drug-resistant cancer stem cells comprising RIN1, SOX15 and TLR4. In one embodiment the cancer stem cells are testicular cancer germ cells. The present invention provides for a kit and method for determining response to treatment with decitabine at low doses.
    Type: Grant
    Filed: July 31, 2013
    Date of Patent: October 25, 2016
    Assignee: Trustees of Dartmouth College
    Inventors: Michael Spinella, Maroun J. Beyrouthy
  • METHOD FOR DETERMINING SENSITIVITY TO DECITABINE TREATMENT
    Publication number: 20150197813
    Abstract: The present invention is a gene expression panel of chemotherapeutic drug-resistant cancer stem cells comprising RIN1, SOX15 and TLR4. In one embodiment the cancer stem cells are testicular cancer germ cells. The present invention provides for a kit and method for determining response to treatment with decitabine at low doses.
    Type: Application
    Filed: July 31, 2013
    Publication date: July 16, 2015
    Applicant: Trustees of Dartmouth College
    Inventors: Michael Spinella, Maroun J. Beyrouthy
  • METHODS FOR IDENTIFYING AND INHIBITING GROWTH OF CHEMOTHERAPEUTIC-RESISTANT CANCERS
    Publication number: 20150174163
    Abstract: The present invention is a biomarker of chemotherapeutic drug-resistant cancer stem cells and a method of inhibiting the growth of drug-resistant cancer stem cells. In one embodiment the cancer stem cells are testicular cancer germ cells. In another embodiment the present invention is a method of overcoming drug resistance in cancer treatment where the combination of low dose decitabine and administration of a chemotherapeutic drug to which cancer cells were resistant results in successful cancer treatment.
    Type: Application
    Filed: March 6, 2015
    Publication date: June 25, 2015
    Applicant: Trustees of Dartmouth College
    Inventors: Michael Spinella, Maroun J. Beyrouthy
  • Method and Kit for Determining Sensitivity to Decitabine Treatment
    Publication number: 20130023439
    Abstract: The present invention is a gene expression panel of chemotherapeutic drug-resistant cancer stem cells comprising RIN1, SOX15 and TLR4. In one embodiment the cancer stem cells are testicular cancer germ cells. The present invention provides for a kit and method for determining response to treatment with decitabine at low doses.
    Type: Application
    Filed: August 10, 2012
    Publication date: January 24, 2013
    Applicant: Trustees of Dartmouth College
    Inventors: Michael Spinella, Maroun J. Beyrouthy
  • Compositions for Inhibiting Growth of Cancer Stem Cells
    Publication number: 20120156312
    Abstract: The present invention is a biomarker of chemotherapeutic drug-resistant cancer stem cells and a method of inhibiting the growth of drug-resistant cancer stem cells. In one embodiment the cancer stem cells are testicular cancer germ cells. In another embodiment the present invention is a method of overcoming drug resistance in cancer treatment where the combination of low dose decitabine and administration of a chemotherapeutic drug to which cancer cells were resistant results in successful cancer treatment.
    Type: Application
    Filed: August 30, 2010
    Publication date: June 21, 2012
    Applicant: Trustees of Dartmouth College
    Inventors: Michael Spinella, Maroun J. Beyrouthy