Patents by Inventor Michael Spino

Michael Spino has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11723874
    Abstract: The invention is directed to pharmaceutical compositions such as tablets that exhibit delayed release properties when administered as either whole or half tablets. The invention is also directed to delayed release tablets comprising deferiprone for oral administration, for which twice daily administration is bioequivalent to the same daily dose of an immediate release tablet administered thrice daily. The invention is also directed to methods of making and using the same.
    Type: Grant
    Filed: May 21, 2021
    Date of Patent: August 15, 2023
    Assignee: Chiesi Farmaceutici S.p.A.
    Inventors: Bernard Charles Sherman, Michael Spino
  • Patent number: 11607389
    Abstract: The invention is directed to pharmaceutical compositions such as tablets that exhibit delayed release properties when administered as either whole or half tablets. The invention is also directed to delayed release tablets comprising deferiprone for oral administration, for which twice daily administration is bioequivalent to the same daily dose of an immediate release tablet administered thrice daily. The invention is also directed to methods of making and using the same.
    Type: Grant
    Filed: May 12, 2022
    Date of Patent: March 21, 2023
    Assignee: Chiesi Farmaceutici S.p.A.
    Inventors: Bernard Charles Sherman, Michael Spino
  • Patent number: 11458103
    Abstract: The invention is directed to pharmaceutical compositions such as tablets that exhibit delayed release properties when administered as either whole or half tablets. The invention is also directed to delayed release tablets comprising deferiprone for oral administration, for which twice daily administration is bioequivalent to the same daily dose of an immediate release tablet administered thrice daily. The invention is also directed to methods of making and using the same.
    Type: Grant
    Filed: December 13, 2019
    Date of Patent: October 4, 2022
    Assignee: Chiesi Farmaceutici S.p.A.
    Inventors: Bernard Charles Sherman, Michael Spino
  • Publication number: 20220265559
    Abstract: The invention is directed to pharmaceutical compositions such as tablets that exhibit delayed release properties when administered as either whole or half tablets. The invention is also directed to delayed release tablets comprising deferiprone for oral administration, for which twice daily administration is bioequivalent to the same daily dose of an immediate release tablet administered thrice daily. The invention is also directed to methods of making and using the same.
    Type: Application
    Filed: May 12, 2022
    Publication date: August 25, 2022
    Inventors: Bernard Charles SHERMAN, Michael SPINO
  • Patent number: 11357731
    Abstract: The invention is directed to pharmaceutical compositions such as tablets that exhibit delayed release properties when administered as either whole or half tablets. The invention is also directed to delayed release tablets comprising deferiprone for oral administration, for which twice daily administration is bioequivalent to the same daily dose of an immediate release tablet administered thrice daily. The invention is also directed to methods of making and using the same.
    Type: Grant
    Filed: April 3, 2020
    Date of Patent: June 14, 2022
    Assignee: CHIESI FARMACEUTICI S.P.A.
    Inventors: Bernard Charles Sherman, Michael Spino
  • Publication number: 20210386677
    Abstract: The invention is directed to pharmaceutical compositions such as tablets that exhibit delayed release properties when administered as either whole or half tablets. The invention is also directed to delayed release tablets comprising deferiprone for oral administration, for which twice daily administration is bioequivalent to the same daily dose of an immediate release tablet administered thrice daily. The invention is also directed to methods of making and using the same.
    Type: Application
    Filed: May 21, 2021
    Publication date: December 16, 2021
    Inventors: Bernard Charles SHERMAN, Michael SPINO
  • Patent number: 10940116
    Abstract: The invention is directed to pharmaceutical compositions such as tablets that exhibit delayed release properties when administered as either whole or half tablets. The invention is also directed to delayed release tablets comprising deferiprone for oral administration, for which twice daily administration is bioequivalent to the same daily dose of an immediate release tablet administered thrice daily. The invention is also directed to methods of making and using the same.
    Type: Grant
    Filed: October 25, 2018
    Date of Patent: March 9, 2021
    Assignee: Chiesi Farmaceutici S.p.A.
    Inventors: Bernard Charles Sherman, Michael Spino
  • Patent number: 10940115
    Abstract: The invention is directed to pharmaceutical compositions such as tablets that exhibit delayed release properties when administered as either whole or half tablets. The invention is also directed to delayed release tablets comprising deferiprone for oral administration, for which twice daily administration is bioequivalent to the same daily dose of an immediate release tablet administered thrice daily. The invention is also directed to methods of making and using the same.
    Type: Grant
    Filed: May 12, 2020
    Date of Patent: March 9, 2021
    Assignee: Chiesi Farmaceutici S.p.A.
    Inventors: Bernard Charles Sherman, Michael Spino
  • Patent number: 10780055
    Abstract: The invention is directed to pharmaceutical compositions such as tablets that exhibit delayed release properties when administered as either whole or half tablets. The invention is also directed to delayed release tablets comprising deferiprone for oral administration, for which twice daily administration is bioequivalent to the same daily dose of an immediate release tablet administered thrice daily. The invention is also directed to methods of making and using the same.
    Type: Grant
    Filed: October 25, 2018
    Date of Patent: September 22, 2020
    Assignee: Chiesi Farmaceutici S.p.A.
    Inventors: Bernard Charles Sherman, Michael Spino
  • Publication number: 20200268672
    Abstract: The invention is directed to pharmaceutical compositions such as tablets that exhibit delayed release properties when administered as either whole or half tablets. The invention is also directed to delayed release tablets comprising deferiprone for oral administration, for which twice daily administration is bioequivalent to the same daily dose of an immediate release tablet administered thrice daily. The invention is also directed to methods of making and using the same.
    Type: Application
    Filed: May 12, 2020
    Publication date: August 27, 2020
    Inventors: Bernard Charles SHERMAN, Michael SPINO
  • Publication number: 20200253945
    Abstract: The invention is directed to pharmaceutical compositions such as tablets that exhibit delayed release properties when administered as either whole or half tablets. The invention is also directed to delayed release tablets comprising deferiprone for oral administration, for which twice daily administration is bioequivalent to the same daily dose of an immediate release tablet administered thrice daily. The invention is also directed to methods of making and using the same.
    Type: Application
    Filed: October 25, 2018
    Publication date: August 13, 2020
    Inventors: Bernard Charles SHERMAN, Michael SPINO
  • Publication number: 20200237674
    Abstract: The invention is directed to pharmaceutical compositions such as tablets that exhibit delayed release properties when administered as either whole or half tablets. The invention is also directed to delayed release tablets comprising deferiprone for oral administration, for which twice daily administration is bioequivalent to the same daily dose of an immediate release tablet administered thrice daily. The invention is also directed to methods of making and using the same.
    Type: Application
    Filed: April 3, 2020
    Publication date: July 30, 2020
    Inventors: Bernard Charles SHERMAN, Michael SPINO
  • Publication number: 20200188309
    Abstract: The invention is directed to pharmaceutical compositions such as tablets that exhibit delayed release properties when administered as either whole or half tablets. The invention is also directed to delayed release tablets comprising deferiprone for oral administration, for which twice daily administration is bioequivalent to the same daily dose of an immediate release tablet administered thrice daily. The invention is also directed to methods of making and using the same.
    Type: Application
    Filed: December 13, 2019
    Publication date: June 18, 2020
    Inventors: Bernard Charles SHERMAN, Michael SPINO
  • Publication number: 20190125682
    Abstract: The invention is directed to pharmaceutical compositions such as tablets that exhibit delayed release properties when administered as either whole or half tablets. The invention is also directed to delayed release tablets comprising deferiprone for oral administration, for which twice daily administration is bioequivalent to the same daily dose of an immediate release tablet administered thrice daily. The invention is also directed to methods of making and using the same.
    Type: Application
    Filed: October 25, 2018
    Publication date: May 2, 2019
    Inventors: Bernard Charles SHERMAN, Michael SPINO
  • Publication number: 20190117581
    Abstract: The invention is directed to pharmaceutical compositions such as tablets that exhibit delayed release properties when administered as either whole or half tablets. The invention is also directed to delayed release tablets comprising deferiprone for oral administration, for which twice daily administration is bioequivalent to the same daily dose of an immediate release tablet administered thrice daily. The invention is also directed to methods of making and using the same.
    Type: Application
    Filed: October 25, 2018
    Publication date: April 25, 2019
    Inventors: Bernard Charles SHERMAN, Michael SPINO
  • Patent number: 9791147
    Abstract: The present document describes a multistages combustion furnace system for thermal expansion of mineral particles which comprises: a furnace having an expansion chamber for receiving the mineral particles; a burner head to be connected at a distance for an atmospheric coupling of the furnace and for operating the multistages combustion furnace system; a furnace device to be connected at a distance for an atmospheric coupling of the burner head to offset the quenching effect of ambient air normally drawn in the furnace; and a tuyere for thermal expansion of mineral particles to be connected between the expansion chamber and the furnace device; wherein the multistage combustion furnace system is to be connected with an inlet of preheated air.
    Type: Grant
    Filed: October 5, 2011
    Date of Patent: October 17, 2017
    Assignee: TERAJOULE INC.
    Inventor: Michael Spino
  • Publication number: 20140314676
    Abstract: The current application is directed to methods of treating or ameliorating myocardial ischemia, an acute coronary event, and a myocardial reperfusion injury comprising administering a therapeutically effective amount of deferiprone or a pharmaceutically acceptable salt thereof to a patient in need thereof. The application is also directed to reducing the risk for myocardial reperfusion injury as well as promoting the beneficial remodeling of cardiac tissue in a patient, comprising administering a therapeutically effective amount of deferiprone or a pharmaceutically acceptable salt thereof to a patient before, during or after reperfusion therapy. The application also includes methods of selecting a patient for treatment of reperfusion injury and subsequently treating the selected patient.
    Type: Application
    Filed: November 16, 2012
    Publication date: October 23, 2014
    Inventors: Michael Spino, John Chalmers Connelly, John Charles Wood, Graham Arnold Wright, Nilesh Ramesh Ghugre
  • Patent number: 8703156
    Abstract: An oral pharmaceutical liquid formulation comprising deferiprone and a taste masking composition, said taste masking composition comprising an effective amount of a sweetener (such as sucralose) per liter of liquid composition, an effective amount of a thickening and suspension aid, (for example hydroxyethylcellulose), per liter of liquid composition, an effective amount of a humectant (such as glycerin) per liter of liquid composition, and an effective amount of at least one flavoring agent, wherein a final form of said taste-masked pharmaceutical has a substantially non-bitter and palatable taste.
    Type: Grant
    Filed: April 25, 2008
    Date of Patent: April 22, 2014
    Assignee: Apotex Technologies Inc.
    Inventors: Michael Spino, Anita Hui, Cihua Yang, Mohammed N. Kabir
  • Publication number: 20130190365
    Abstract: A therapeutically effective amount of deferiprone or deferasirox or physiologically acceptable salts thereof for the prevention, stabilization, treatment, or reversal of iron-induced FRDA disease in patients resulting from mitochondrial iron-induced damage to preferentially reduce the iron stores in the mitochondria. Also for the treatment of other conditions affecting the brain where a key element in the generation of the resultant pathology is the intracellular mishandling of iron.
    Type: Application
    Filed: January 31, 2013
    Publication date: July 25, 2013
    Inventors: Arnold Munnich, Michael Spino, Ioav Cabantchik
  • Publication number: 20130023569
    Abstract: There is provided use of orally available or topically applied deferiprone for prevention of iron-induced eye damage. The use may be for preparation of a medicament or in a method of preventing iron-induced eye damage to an eye of a subject at risk for iron-induced eye damage, the method comprising administering a prophylactically effective amount of deferiprone to the subject. There is also provided the use of deferiprone for treatment of iron-related eye disorders. The use may be for preparation of a medicament or in a method of treatment of damage to an eye of a having eye damage associated with iron, the method comprising topically administering a therapeutically effective amount of deferiprone to the subject.
    Type: Application
    Filed: November 12, 2009
    Publication date: January 24, 2013
    Applicants: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, APOTEX TECHNOLOGIES INC.
    Inventors: Michael Spino, Joshua Lawrence Dunaief