Abstract: Compositions and methods for the preparation of nanoemulsion from oils are disclosure. These nanoemulsions can be produced without the addition of exogenous surfactants or emulsifiers and can be useful as carriers for active ingredients.

Abstract: Stabilized TCR constructs comprising a TCR alpha chain polypeptide having a variable alpha (V?) domain and a constant alpha (C?) domain and a TCR beta chain polypeptide having a variable beta (V?) domain and a constant beta (C?) domain. The TCR constructs are stabilized by the introduction into the C? domain and/or the C? domain of stabilizing mutations such as non-naturally occurring disulfide bonds between the C? domain and the C? domain (an interchain disulfide bond), non-naturally occurring intrachain disulfide bonds, point mutations, loop truncation mutations, and combinations thereof. TCR fusion proteins comprising one or more of the TCR constructs and a scaffold and/or other biologically active moiety are also described.

Abstract: The present invention provides a method for the treatment of a patient comprising administering to the patient an initial dose of between about 1 mg and about 150 mg of a MAdCAM antagonist antibody. Biomarkers for assessing a patient's response to anti-MAdCAM treatment are also provided.

Abstract: Compositions, methods and systems are provided for pulmonary or nasal delivery of two or more active agents via a metered dose inhaler. In one embodiment, the compositions include a suspension medium, active agent particles, and suspending particles, in which the active agent particles and suspending particles form a co-suspension within the suspension medium.

Abstract: Provided herein are fusion protein constructs that can bind a complement-associated antigen, comprising a targeting moiety and a complement modulator protein, or a fragment thereof or a variant thereof. The targeting moiety is an antibody or an antigen binding fragment thereof, in some examples. Further provided are methods of using the fusion protein constructs, for example, in treating complement mediation conditions.

Abstract: A tip valve and a cook system incorporating same that automatically stops the flow of gas to a burner when tipped over and that automatically resets when disconnected from the fuel canister to allow the flow of gas to resume when righted and reconnected are provided. The tip valve includes a ball bearing freely moveable between a fuel canister actuator pin and a tip seal within a bore having two different diameters at each end thereof. The transition between the two diameters forms a taper that may be continuous forming a smooth tapered bore, or discontinuous formed by at least one counter bore. The automatic resetting is provided without the use of a mechanical pin or member.

Abstract: A computer-implemented system and method for automated traffic flow control using domain name for one or more devices enabled for connectivity over cellular network are disclosed. The computer-implemented method for automated traffic flow control using domain name for one or more devices enabled for connectivity includes receiving device information for the one or more devices; receiving domain name information for at least one domain name that the one or more devices are allowed to access, denied to access or a combination thereof; associating the at least one domain name with one or more internet protocol (IP) addresses; monitoring the at least one domain for change in the one or more IP addresses for that domain; and updating the one or more IP addresses of the domain name if any change in the one or more IP addresses for that domain is found.

Abstract: A process for using temperature measurements to determine health metrics includes: a) using a first temperature sensor of a wearable device to obtain a first set of measurements at a first location on a user's body over a time period; b) using a second temperature sensor of the wearable device to obtain a second set of measurements at a second location on the user's body over the time period; c) processing the measurements to identify changes in temperature over the time period, determining a first health metric based on the changes, and outputting an indication of the first health metric; and d) processing the measurements to compare the temperature at the first location at a given time point to the temperature at the second location at the given time point, determining a second health metric based on the comparison, and outputting an indication of the second health metric.

Abstract: The field of the present invention relates to immunotherapeutic peptides, peptide binding agents, and their use, for example, in the immunotherapy of cancer.

Abstract: An autonomous vehicle may access portions of a map to maneuver a roadway. The map may be split into one or more levels that represent different regions in space. For example, an overpass may be represented by one level while the road below the overpass may be on a separate level. A vehicle traveling on a particular level may use map data that is associated with that level. Furthermore, if the vehicle travels through a warp zone, it may transition from the current level to a destination level and thus begin to use map data associated with the destination level.

Abstract: A method and system for activity classification. A pressure sensor receives input data resulting from physical activity of a subject performing an activity. The input data includes pressure data from at least one pressure sensor, and may include other data acquired through other types of sensors. A deep learning neural network is applied to the input data for identifying the activity. The neural network is trained with reference to training data from a training database. The training data may include empirical data from a database of previous data of corresponding activities, synthesized data prepared from the empirical data or simulated data. The training data may include data from physical activity of the subject being monitored by the system. Different aspects of the neural network may be trained with reference to the training data, and some aspects may be locked or opened depending on the application and the circumstances.

Abstract: The field of the present invention relates to immunotherapeutic peptides, peptide binding agents, and their use, for example, in the immunotherapy of cancer.

Abstract: A system and method for measuring resistance over an array. The array includes at least three electrodes. Nodes at each intersection between input electrodes and output electrodes have variable resistance. A driving voltage is applied to a selected input electrode and an output current is received at a selected output electrode. A selected node is at the intersection of the two selected electrodes and includes an electrical component with a resistive property. Remaining electrodes are connected with a ground for isolating the selected node from the effects of changes in impedance of the remaining nodes. The driving voltage is converted to an output current by resistance at the selected node. The output current is converted to an output voltage with a current-to-voltage converter circuit for measuring the resistance of the electrical component. The nodes may be measured as the selected node in sequential or non-sequential patterns.

Abstract: Apparatuses, systems, and techniques to optimize memory usage when performing matrix operations. In at least one embodiment, a matrix is optimized to limit memory and storage requirements while minimizing loss of precision for a sum of the members of the matrix.

Abstract: Example systems and methods allow for reporting and sharing of information reports relating to driving conditions within a fleet of autonomous vehicles. One example method includes receiving information reports relating to driving conditions from a plurality of autonomous vehicles within a fleet of autonomous vehicles. The method may also include receiving sensor data from a plurality of autonomous vehicles within the fleet of autonomous vehicles. The method may further include validating some of the information reports based at least in part on the sensor data. The method may additionally include combining validated information reports into a driving information map. The method may also include periodically filtering the driving information map to remove outdated information reports. The method may further include providing portions of the driving information map to autonomous vehicles within the fleet of autonomous vehicles.

Abstract: A fluidic handling unit includes a baseplate, a fluidic inlet block, a fluidic outlet block, a pump in fluidic communication with the fluidic inlet block and the fluidic outlet block, a carrier control board in electrical communication with the pump, and a flow cell carrier comprising a microfluidic flow cell receiving area, wherein the flow cell carrier is configured to receive and retain the fluidic handling unit. A bottom surface of the fluidic handling unit is configured to complementary mate with a top surface of the flow cell carrier, or wherein a bottom surface of the flow cell carrier is configured to complementarily mate with a top surface of the fluidic handling unit.

Abstract: Aspects of the disclosure relate to validating map data using challenge questions. For instance, an attributes to be validated may be identified from the map data. At least one challenge question may be selected from a plurality of predetermined challenge questions based on the attribute. An image may be retrieved based on image information associated with the at least one challenge question. The image and the at least one challenge question may be provided for display. In response to the providing, operator input identifying an answer to the at least one challenge question may be received. This answer may be then used to validate the attribute.

Abstract: Methods and systems disclosed herein relate to providing a receiving entity with a package of assertions. A package of assertions may include a group of yes or no statements (e.g., as an answer to a question). Alternatively, or additionally, a package of assertions may comprise a clustered assertion, which is a singular yes or no statement, that is itself based on a set of underlying assertions made using information from one or more sources. A particular type of package of assertions may be selected based on the relying entity requesting the assertions, based on an assertions model. The package of assertions may be cryptographically secured.

Abstract: A positioning device for aligning and guiding a first half and a second half of a mold together. The positioning device may comprise a housing including identical wall members configured to define a cavity. Each of the wall members comprise a tab, the tab defining a recess and a protrusion on opposed sides of the tab such that the protrusion and recess defined by the tab of one of the wall member is configured to interlock with the recess or protrusion of the tab of an adjacent wall member to connect adjacent wall members. A first member may be slidably disposed within the cavity of the housing, the first member defining a void. The positioning device may further comprise a second member comprising a base and a protrusion, wherein the protrusion is configured to matingly engage the void of the first member.

Abstract: A system and method for measuring resistance over an array. The array includes at least three electrodes. Nodes at each intersection between input electrodes and output electrodes have variable resistance. A driving voltage is applied to a selected input electrode and an output current is received at a selected output electrode. A selected node is at the intersection of the two selected electrodes and includes an electrical component with a resistive property. Remaining electrodes are connected with a ground for isolating the selected node from the effects of changes in impedance of the remaining nodes. The driving voltage is converted to an output current by resistance at the selected node. The output current is converted to an output voltage with a current-to-voltage converter circuit for measuring the resistance of the electrical component. The nodes may be measured as the selected node in sequential or non-sequential patterns.