Abstract: There is provided inter alia polypeptides such as antibodies or fragments thereof which bind to LPAR1.

Abstract: Provided herein are methods, systems, and compositions for determining a base in a polynucleotide. In various aspects, the methods, systems, and compositions presented herein are useful for performing 4-base, 5-base, or 6-base sequencing of polynucleotide molecules, for example, from liquid biopsy samples or wherein the base is a low frequency mutation.

Abstract: There is provided inter alia polypeptides such as antibodies or fragments thereof which bind to LPAR1.

Abstract: Provided herein are systems and methods for detection of an epigenetic modification in a nucleic acid sequence. The systems and methods as described herein may provide a substantially unbiased approach in detecting an epigenetic modification. The systems and method as described herein may provide a substantially unbiased approach in detecting an epigenetic modification in comparison to systems and methods that amplify sequences having a label or a moiety associated with an epigenetic modification.

Abstract: Provided herein are methods, systems, and compositions for determining a base in a polynucleotide. In various aspects, the methods, systems, and compositions presented herein are useful for performing 4-base, 5-base, or 6-base sequencing of polynucleotide molecules, for example, from liquid biopsy samples or wherein the base is a low frequency mutation.

Abstract: A vertiport exchange station has a plurality of vertical takeoff and landing (VTOL) air taxis, a plurality of landing/takeoff pads arranged in a rectangular pattern, a passenger terminal for arrival and departure of passengers, a plurality of electric motor driven chassis each adapted to carry a pod adapted to carry one or more passengers, a transfer path guiding the chassis in a closed loop, and a control system. One or more incoming passengers enter a pod at the passenger terminal, an air taxi is guided to a specific pad, the chassis carrying the pod is transported to a point near the specific pad, is guided to stop on the specific pad, the air taxi is guided to connect to the pod, the pod is detached from the chassis, and the air taxi is guided to ascend and to proceed to a programmed destination.

Abstract: A control system and apparatus for managing charging of electric vehicles in a transportation infrastructure and controlling at least the flight paths for drone-assisted vehicles requiring periodic charge comprises a transportation system control node connected in a first wide area network (WAN), a plurality of vehicle charging facilities distributed within the geographic region covered by the first wide area network and a charge controller connected to each of the plurality of charging facilities for brokering electric power from a power source to at least one structurally supported charge transfer apparatus maintained at each of the charging facilities.

Abstract: Provided herein are methods, systems, and compositions for determining a base in a polynucleotide. In various aspects, the methods, systems, and compositions presented herein are useful for performing 4-base, 5-base, or 6-base sequencing of polynucleotide molecules, for example, from liquid biopsy samples or wherein the base is a low frequency mutation.

Abstract: Provided herein are methods, systems, and compositions for determining a base in a polynucleotide. In various aspects, the methods, systems, and compositions presented herein are useful for performing 4-base, 5-base, or 6-base sequencing of polynucleotide molecules, for example, from liquid biopsy samples or wherein the base is a low frequency mutation.

Abstract: A transportation system has transport vehicles with electric motors, pods, being enclosed compartments that accommodate cargo, podports, being exchange stations, charging stations, and a computerized transport control system. An authorized person communicates a request to the computerized transport control system to transport a specific cargo from a first location in the geographic area to a second location in the geographic area, the computerized transport control system defines a journey from the first location to the second location, along a route comprising sequential hops through a series of podports and charging stations. The computerized transport control system manages movement of transport vehicles, exchanges at podports, and charging at charging stations along the defined route, and terminates the journey at the second location where the cargo disembarks.

Abstract: A passenger transport system has a pod adapted to carry passengers or articles and a first attachment interface, a plurality of transport vehicles, each adapted to couple to the passenger pod, a first entry station adapted to load a passenger or articles into the pod, a plurality of exchange points, and a final destination station adapted to unload the passenger or articles from the pod carried by the transport vehicle. The pod with a passenger or articles is loaded at the first entry station travels on transport vehicles between individual ones of the exchange stations, until arriving at the final destination station where the passenger or the articles are unloaded, the passenger or articles remaining in the pod through all exchanges between transport vehicles.

Abstract: The present invention relates to modified proteins and peptides that have reduced ability to bind to pre-existing antibodies. Such modified protein/peptide molecules can comprise C-terminal additions, extensions or tags and/or certain amino acid substitutions. Such modified molecules (e.g. fusions and conjugates) comprise proteins, peptides, antigen binding molecules, antibodies or antibody fragments such as single variable domains e.g. human immunoglobulin (antibody) single variable domains, and also single variable domains derived from non-human sources such as a llama or camel, e.g. a VHH including a Nanobody™ (described in e.g. WO 94/04678 and WO 95/04079 inter alia). The invention further relates to uses, formulations, compositions comprising such modified C terminally extended and/or amino acid substituted molecules and also to methods of production and expression of these molecules.

Abstract: An autonomous system for managing power distribution to an electrically-powered device that includes a power controller module that includes power input and power output abilities and operably connected power switching abilities, wherein the power switching is configured for actuation by an integral power management module operably connected thereto, the integral power management module including integral actuation signal detection and actuation abilities configured for, in accordance with commands and operational parameters, upon detection of an actuation signal, actuation the integral power switching to alter power output through the power output from a first output level to a second output level.

Abstract: A passenger transport system has a pod adapted to carry passengers or articles and a first attachment interface, a plurality of transport vehicles, each adapted to couple to the passenger pod, a first entry station adapted to load a passenger or articles into the pod, a plurality of exchange points, and a final destination station adapted to unload the passenger or articles from the pod carried by the transport vehicle. The pod with a passenger or articles is loaded at the first entry station travels on transport vehicles between individual ones of the exchange stations, until arriving at the final destination station where the passenger or the articles are unloaded, the passenger or articles remaining in the pod through all exchanges between transport vehicles.

Abstract: The present disclosure relates to modified proteins and peptides that have reduced ability to bind to pre-existing antibodies. Such modified protein/peptide molecules can comprise C-terminal additions, extensions or tags and/or certain amino acid substitutions. Such modified molecules (e.g., fusions and conjugates) comprise proteins, peptides, antigen binding molecules, antibodies or antibody fragments such as single variable domains. The disclosure further relates to uses and formulations of compositions comprising such modified C-terminally extended and/or amino acid substituted molecules and also to methods of production and expression of these.

Abstract: A method for transporting a person or a parcel from a first location to a second location involves mounting a pod having a rechargeable battery and a compartment to a first vehicle, moving the first vehicle with the pod mounted to a loading position at or near the first location, loading a person or a parcel into the pod, moving the first transporter vehicle from the loading position to a first exchange point, exchanging the passenger pod from the first transporter vehicle to a second transporter vehicle at the first exchange point by de-mounting the pod from the first transporter vehicle and mounting the pod to the second transporter vehicle by a compatible physical interface between the pod and the second transporter vehicle, and transporting the second transporter vehicle with the pod to the second location.

Abstract: A control system and apparatus for managing charging of electric vehicles in a transportation infrastructure and controlling at least the flight paths for drone-assisted vehicles requiring periodic charge comprises a transportation system control node connected in a first wide area network (WAN), a plurality of vehicle charging facilities distributed within the geographic region covered by the first wide area network and a charge controller connected to each of the plurality of charging facilities for brokering electric power from a power source to at least one structurally supported charge transfer apparatus maintained at each of the charging facilities.

Abstract: An autonomous system for managing power distribution to an electrically-powered device that includes a power controller module that includes power input and power output abilities and operably connected power switching abilities, wherein the power switching is configured for actuation by an integral power management module operably connected thereto, the integral power management module including integral actuation signal detection and actuation abilities configured for, in accordance with commands and operational parameters, upon detection of an actuation signal, actuation the integral power switching to alter power output through the power output from a first output level to a second output level.

Abstract: A method for transporting a person or a parcel from a first location to a second location involves mounting a pod having a rechargeable battery and a compartment to a first vehicle, moving the first vehicle with the pod mounted to a loading position at or near the first location, loading a person or a parcel into the pod, moving the first transporter vehicle from the loading position to a first exchange point, exchanging the passenger pod from the first transporter vehicle to a second transporter vehicle at the first exchange point by de-mounting the pod from the first transporter vehicle and mounting the pod to the second transporter vehicle by a compatible physical interface between the pod and the second transporter vehicle, and transporting the second transporter vehicle with the pod to the second location.

Abstract: An exchange station has openings for drones, a passenger check-in/check-out bay for processing passengers, a drone connect/release bay, having apparatus adapted to manage passenger pods mounted on smart chassis, and a computerized control system in wireless communication with control circuitry in the drones and smart chassis, guiding smart chassis with mounted passenger pods and drones, to make the exchange of pods from the smart chassis to drones. A passenger entering the passenger check-in bay is loaded into a pod mounted on a smart chassis, the pod with passenger is transported to the drone-connect/release bay, and the pod is there joined to a bare drone and disconnected from the smart chassis, the drone leaving with the passenger pod to a destination, and the smart chassis traveling away from the drone connect-release bay.