Patents by Inventor Michael Strauss

Michael Strauss has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 6130092
    Abstract: A ribozyme library which comprises a collection of ribozyme genes encoding a hammerhead structure and flanking sequences of random nucleotides cloned at least once into an expression cassette for ribozyme expression.
    Type: Grant
    Filed: July 3, 1997
    Date of Patent: October 10, 2000
    Assignee: Max-Planck Gesellschaft zur Forderung der Wissenschaften e.V.
    Inventors: Andre Lieber, Michael Strauss, deceased
  • Patent number: 6046050
    Abstract: The invention refers to a new human liver cell line which may be used for toxicological, physiological and, in particular, gene therapeutic examinations. Fields of application are molecular biology, medicine and pharmaceutical industry. The new human liver cell line is marked positive owing to the parameters albumin and alpha-1-antitrypsin (ATT) and negative owing to alpha-fetoprotein (AFP). It has been deposited in the Deutsche Sammlung von Mikroorganismen (DSM ACC2302).
    Type: Grant
    Filed: March 5, 1998
    Date of Patent: April 4, 2000
    Assignee: HepaVec AG fur Gentherapie
    Inventors: Michael Strauss, Ira Kirillowa
  • Patent number: 6025195
    Abstract: The invention concerns an adenovirus vector for liver specific gene thera fields of application in medicine are the treatment of gene defects and tumour diseases of the liver and molecular biology. The vector according to the invention is marked by the fact that a therapeutic gene is coupled with a liver-specific promoter consisting of enhancer elements of the hepatitis B virus and an enhancerless minimum promoter and is optionally surrounded by SAR elements wherein the promoter is inserted into the adenovirus genome.
    Type: Grant
    Filed: April 23, 1998
    Date of Patent: February 15, 2000
    Assignee: Max-Planck-Gesellschaft zur Forderung der Wissenschaften E.V. Berlin
    Inventors: Volker Sandig, Peter Loser, Michael Strauss
  • Patent number: 5895759
    Abstract: A tissue-specific, suitably liver specific vector for gene therapy of a diseased host, wherein a therapeutic gene is coupled to a promoter chemically, enzymatically, or over an antibody, packaged in a polypeptide coat, and coupled to a component of a preselected virus of the tissue to be treated, and when the tissue is liver tissue, then the virus is hepatitis B virus.
    Type: Grant
    Filed: September 3, 1996
    Date of Patent: April 20, 1999
    Assignee: Max-Planck Gesellschaft zur Forderung der Wissenschaften e.V.
    Inventors: Michael Strauss, Volker Sandig, Christian Hofmann
  • Patent number: 5831067
    Abstract: Agents for stimulating the dividing activity of mammalian cells are presented, which have as an active substance a nucleotide sequence with a complimentary sequence (anti-sense) to a domain of the mRNA of tumor suppressor retinoblastoma or p16 genes acting on cell dividing activity. For Rb, the agents are nucleotide sequences5'-GGTTTTGGGCGGCATGAC-3' (SEQ ID NO: 1) and5'-CTCAGTAAAAGTGAACGA-3' (SEQ ID NO: 2); a nucleotide sequence comprising 49 base pairs, wherein the domain of the mRNA comprises nucleotides 124 to 152; and a 360 base pair nucleotide wherein the domain of the mRNA comprises an Hpa I restriction endonuclease site, an ASP718 endonuclease site, a portion of the 5' untranslated domain of the Rb gene, and a first exon of the Rb gene. For p16, the agent comprises GATCCATGCT GCTCC (SEQ ID NO: 3).
    Type: Grant
    Filed: August 7, 1995
    Date of Patent: November 3, 1998
    Assignee: Max-Planck-Gesellschaft zur Forderung der Wissenschaften e.V.
    Inventors: Michael Strauss, Andre Lieber
  • Patent number: 5695992
    Abstract: The invention is an expression cassette for the antisense expression of ribozyme, having a strong promotor, suitably a T7 promotor, an adenoviral va-RNA gene, a stable loop region, and an insertion site for the antisense/ribozyme sequence in the loop region.
    Type: Grant
    Filed: September 28, 1994
    Date of Patent: December 9, 1997
    Assignee: Max Planck Gesellschaft
    Inventors: Andre Lieber, Michael Strauss
  • Patent number: 5165280
    Abstract: The object of the invention is a device for ultrasonic inspection of cylindrical objects. A transmitting ultrasonic transducer generates ultrasonic waves that are acoustically irradiated into the respective object via a coupling medium. At least three ultrasonic transducers are arranged in a row next to one another along a line. The outer ultrasonic transducers are receiving ultrasonic transducers. The other ultrasonic transducers are transmitting or transmitting/receiving ultrasonic transducers. The line is inclined against the longitudinal axis of the object by an angle which is between 0.degree.and 45.degree..
    Type: Grant
    Filed: October 30, 1990
    Date of Patent: November 24, 1992
    Assignee: Nukem GmbH
    Inventors: Walter Sternberg, Michael Schmeisser, Michael Strauss