Abstract: A method for reducing, inhibiting, preventing or treating cytotoxicity in a cell, the method comprising expressing or overexpressing in the cell a Rho guanine nucleotide exchange factor (RGNEF), or a RGNEF analog or agonist, or a leucine rich domain of RGNEF, whereby the cytotoxicity in the cell is reduced, inhibited, prevented or treated. Also a method of shifting the survival curve of a subject and thereby increasing life expectancy of the subject by administering to the subject a physiologically effective amount of a peptide comprising A Rho Guanine Nucleotide Exchange Factor (RGNEF) protein, or a RGNEF analog or agonist, or a leucine rich domain of RGNEF, or expressing or overexpressing RGNEF or a RGNEF analog or agonist or a leucine rich domain of RGNEF in the subject.

Abstract: An injection moldable composition, comprising: A) a silicone resin (I) [R13SiO1/2]a[R2R3SiO2/2]b[SiO4/2]c, wherein R1, R2, and R3 are hydrocarbyl, hydrocarbyloxy, or hydroxyl, at least one of R2 or R3 is alkenyl, subscripts a, b, and c are each >0 and a+b+c=1, B) 0 to 90% (w/w), based on the weight of A) and B), of a silicone resin (II) [R43SiO1/2]d[SiO4/2]e wherein R4 is hydrocarbyl, hydrocarbyloxy, or hydroxyl, at least one of R4 is alkenyl, subscripts d and e are each >0, and d+e=1, C) a siloxane polymer having formula (III), [R53SiO1/2]fR6R7SiO2/2]g. wherein R5-7 are hydrocarbyl or hydroxyl, at least one of R5-7 is alkenyl, subscripts f and g are each >0, and f+g=1, D) a silicone crosslinker having at least two silicon-bonded hydrogen atoms per molecule, and E) a hydrosilylation catalyst, wherein the ratio of silicon-bonded hydrogen atoms to carbon-carbon double bonds is from 1.2 to 2.2.

Abstract: An injection moldable composition, comprising: A) a silicone resin (I) [R13SiO1/2]a[R2R3SiO2/2]b[SiO4/2]c, wherein R1, R2, and R3 are hydrocarbyl, hydrocarbyloxy, or hydroxyl, at least one of R2 or R3 is alkenyl, subscripts a, b, and c are each >0 and a+b+c=1, B) 0 to 90% (w/w), based on the weight of A) and B), of a silicone resin (II) [R43SiO1/2]d[SiO4/2]e wherein R4 is hydrocarbyl, hydrocarbyloxy, or hydroxyl, at least one of R4 is alkenyl, subscripts d and e are each >0, and d+e=1, C) a siloxane polymer having formula (III), [R53SiO1/2]fR6R7SiO2/2]g. wherein R5-7 are hydrocarbyl or hydroxyl, at least one of R5-7 is alkenyl, subscripts f and g are each >0, and f+g=1, D) a silicone crosslinker having at least two silicon-bonded hydrogen atoms per molecule, and E) a hydrosilylation catalyst, wherein the ratio of silicon-bonded hydrogen atoms to carbon-carbon double bonds is from 1.2 to 2.2.

Abstract: The present invention provides a secure hardware wallet device, a wallet assembly, system and method for transacting a plurality of cryptocurrencies, the hardware wallet device including means to enable a user to input a secret phrase, a processor adapted to calculate at least one private key to enable a transaction to be performed wirelessly over a communications network to or from the hardware wallet device, wherein neither of the secret phrase nor the at least one private key is stored on the hardware wallet device.

Abstract: This invention is directed to a method for applying a thermal management composition between an LED mounted circuit board and a heat sink, comprising the steps of; (a) applying a deposit of a thermal management composition onto either a second surface of the LED mounted circuit board or onto a surface of a heat sink, through a deposition tool the deposition tool having at least one aperture (401) where the at least one aperture has a perimeter surrounded by sidewalls, where the sidewalls have heights, where the heights are reduced around at least a portion (402) of the perimeter of the apertures on the deposition tool as compared to the average height of the deposition tool and (b) securing the LED mounted circuit board and the heat sink.

Abstract: A hydrosilylation curable composition contains a combination of high and low viscosity polyorganosiloxanes, a silicone resin, a crosslinker, and a catalyst. The composition, and the cured product thereof, is useful in optical devices such as charged coupled devices (CCDs), light emitting diodes (LEDs), lightguides, optical cameras, photo-couplers, and waveguides. Processes for fabricating the optical devices include various molding techniques, including overmolding.

Abstract: A system, method and computer program for controlling devices in a control area network that includes providing a first application programming interface containing a first set of functions in a control area network and coupling one or more functions of the first set of functions with a physical device. The control area network includes a master controller, one or more physical devices, and one or more physical communication interfaces. Coupling one or more functions of the first set of functions with a physical device.

Abstract: A self-contained disposal assembly includes a containment compartment configured to be attached to a diaper; and an attached disposal bag fixedly coupled to the diaper wherein the attached disposable bag is configured to be disposed within the containment compartment and is further configured to envelop the diaper.