Patents by Inventor Michael Super

Michael Super has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20220145365
    Abstract: Methods of analyzing nucleic acids of a cell are provided.
    Type: Application
    Filed: January 26, 2022
    Publication date: May 12, 2022
    Inventors: George M. Church, Jehyuk Lee, Daniel Levner, Michael Super
  • Patent number: 11312949
    Abstract: Described herein are heme-binding compositions and methods relating to their use, for example methods of treatment of sepsis and rhabdomyolysis.
    Type: Grant
    Filed: October 23, 2019
    Date of Patent: April 26, 2022
    Assignee: PRESIDENT AND FELLOWS OF HARVARD COLLEGE
    Inventors: Michael Super, Alexander L. Watters, Philip T. Snell, Donald E. Ingber
  • Patent number: 11293051
    Abstract: Methods of making a three-dimensional matrix of nucleic acids within a cell is provided.
    Type: Grant
    Filed: April 23, 2021
    Date of Patent: April 5, 2022
    Assignee: President and Fellows of Harvard College
    Inventors: George M. Church, Jehyuk Lee, Daniel Levner, Michael Super
  • Patent number: 11293054
    Abstract: The inventions provided herein relate to detection reagents, compositions, methods, and kits comprising the detection reagents for use in detection, identification, and/or quantification of analytes in a sample. Such detection reagents and methods described herein allow multiplexing of many more labeled species in the same procedure than conventional methods, in which multiplexing is limited by the number of available and practically usable colors.
    Type: Grant
    Filed: April 24, 2019
    Date of Patent: April 5, 2022
    Assignee: President and Fellows of Harvard College
    Inventors: Daniel Levner, Je-hyuk Lee, George M. Church, Michael Super
  • Patent number: 11293052
    Abstract: Methods of making a three-dimensional matrix of nucleic acids within a cell is provided.
    Type: Grant
    Filed: April 23, 2021
    Date of Patent: April 5, 2022
    Assignee: President and Fellows of Harvard College
    Inventors: George M. Church, Jehyuk Lee, Daniel Levner, Michael Super
  • Publication number: 20220074936
    Abstract: The disclosure provides methods, compositions, and kits for enhanced detection of microbes in samples and monitoring of antimicrobial activity in a subject.
    Type: Application
    Filed: November 17, 2021
    Publication date: March 10, 2022
    Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGE
    Inventors: Mark J. CARTWRIGHT, Nazita GAMINI, Donald E. INGBER, Martin M. ROTTMAN, Michael SUPER, Julie A. TOMOLONIS, Karen A. SINCLAIR
  • Publication number: 20220056089
    Abstract: The present invention provides for engineered molecular opsonins that may be used to bind biological pathogens or identify subclasses or specific pathogen species for use in devices and systems for treatment and diagnosis of patients with infectious diseases, blood-borne infections or sepsis. An aspect of the invention provides for mannose-binding lectin (MBL), which is an abundant natural serum protein that is part of the innate immune system. The ability of this protein lectin to bind to surface molecules on virtually all classes of biopathogens (viruses, bacteria, fungi, protozoans) make engineered forms of MBL extremely useful in diagnosing and treating infectious diseases and sepsis.
    Type: Application
    Filed: November 9, 2021
    Publication date: February 24, 2022
    Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGE
    Inventors: Michael SUPER, Jeffrey Charles WAY, Donald E. INGBER
  • Patent number: 11236149
    Abstract: Described herein are engineered microbe-targeting molecules, microbe-targeting articles, kits comprising the same, and uses thereof. Such microbe-targeting molecules, microbe-targeting articles, or the kits comprising the same can not only bind or capture of a microbe or microbial matter thereof, but they also have improved capability (e.g., enhanced sensitivity or signal intensity) of detecting a microbe or microbial matter. Thus, the microbe-targeting molecules, microbe-targeting articles, and/or the kit described herein can be used in various applications, e.g., but not limited to assays for detection of a microbe or microbial matter, diagnostic and/or therapeutic agents for diagnosis and/or treatment of an infection caused by microbes in a subject or any environmental surface, and/or devices for removal of a microbe or microbial matter from a fluid.
    Type: Grant
    Filed: May 20, 2020
    Date of Patent: February 1, 2022
    Assignee: PRESIDENT AND FALLOWS OF HARVARD COLLEGE
    Inventors: Alexander Watters, Brendon Dusel, Michael Super, Mark Cartwright, Donald E. Ingber
  • Publication number: 20220025448
    Abstract: The inventions provided herein relate to detection reagents, compositions, methods, and kits comprising the detection reagents for use in detection, identification, and/or quantification of analytes in a sample. Such detection reagents and methods described herein allow multiplexing of many more labeled species in the same procedure than conventional methods, in which multiplexing is limited by the number of available and practically usable colors.
    Type: Application
    Filed: October 12, 2021
    Publication date: January 27, 2022
    Inventors: Daniel Levner, Je-Hyuk Lee, George M. Church, Michael Super
  • Patent number: 11208496
    Abstract: Anti-CD19 B4 antibodies with modified variable regions are disclosed. The modified anti-CD19 variable region polypeptides have alterations to one or more framework regions or complementarity determining regions of the heavy chain variable region or light chain variable region, thereby to reduce a T-cell response.
    Type: Grant
    Filed: September 10, 2018
    Date of Patent: December 28, 2021
    Assignee: Cancer Research Technology LTD.
    Inventors: Michael Super, Jonathan Davis, Pascal Andre Stein
  • Patent number: 11209432
    Abstract: The disclosure provides methods, compositions, and kits for enhanced detection of microbes in samples and monitoring of antimicrobial activity in a subject.
    Type: Grant
    Filed: June 11, 2020
    Date of Patent: December 28, 2021
    Assignee: PRESIDENT AND FELLOWS OF HARVARD COLLEGE
    Inventors: Mark J. Cartwright, Nazita Gamini, Donald E. Ingber, Martin Rottman, Michael Super, Julie A. Tomolonis, Karen A. Sinclair
  • Patent number: 11203623
    Abstract: The present invention provides for engineered molecular opsonins that may be used to bind biological pathogens or identify subclasses or specific pathogen species for use in devices and systems for treatment and diagnosis of patients with infectious diseases, blood-borne infections or sepsis. An aspect of the invention provides for mannose-binding lectin (MBL), which is an abundant natural serum protein that is part of the innate immune system. The ability of this protein lectin to bind to surface molecules on virtually all classes of biopathogens (viruses, bacteria, fungi, protozoans) make engineered forms of MBL extremely useful in diagnosing and treating infectious diseases and sepsis.
    Type: Grant
    Filed: June 4, 2020
    Date of Patent: December 21, 2021
    Assignee: PRESIDENT AND FELLOWS OF HARVARD COLLEGE
    Inventors: Michael Super, Jeffrey Charles Way, Donald E. Ingber
  • Publication number: 20210364522
    Abstract: The invention relates to methods of detection, capture, isolation and targeting of cancer cells for example circulating tumor cells (CTCs) using carbohydrate recognition domain of a lectin. The invention relates to methods of diagnosis, prognosis and treatment of cancer.
    Type: Application
    Filed: August 4, 2021
    Publication date: November 25, 2021
    Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGE
    Inventors: Joo-Hun KANG, Donald E. INGBER, Michael SUPER, Alexander L. WATTERS, Harry Scott DRISCOLL
  • Publication number: 20210332414
    Abstract: Methods of making a three-dimensional matrix of nucleic acids within a cell is provided.
    Type: Application
    Filed: July 2, 2021
    Publication date: October 28, 2021
    Inventors: George M. Church, Jehyuk Lee, Daniel Levner, Michael Super
  • Publication number: 20210332415
    Abstract: Methods of making a three-dimensional matrix of nucleic acids within a cell is provided.
    Type: Application
    Filed: July 2, 2021
    Publication date: October 28, 2021
    Inventors: George M. Church, Jehyuk Lee, Daniel Levner, Michael Super
  • Publication number: 20210299676
    Abstract: Disclosed herein is an improved method for magnetic capture of target molecules (e.g., microbes) in a fluid. Kits and solid substrates for carrying the method described herein are also provided. In some embodiments, the methods, kits, and solid substrates described herein are optimized for separation and/or detection of microbes and microbe-associated molecular pattern (MAMP) (including, e.g., but not limited to, a cell component of microbes, lipopolysaccharides (LPS), and/or endotoxin).
    Type: Application
    Filed: June 10, 2021
    Publication date: September 30, 2021
    Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGE
    Inventors: Joo Hun KANG, Donald E. INGBER, Michael SUPER
  • Publication number: 20210277079
    Abstract: Described herein are engineered microbe-targeting molecules, microbe-targeting articles, kits comprising the same, and uses thereof. Such microbe-targeting molecules, microbe-targeting articles, or the kits comprising the same can bind or capture of a microbe or microbial matter thereof, and can thus be used in various applications, such as diagnosis or treatment of an infection caused by microbes in a subject or any environmental surface.
    Type: Application
    Filed: May 12, 2021
    Publication date: September 9, 2021
    Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGE
    Inventors: Alexander L. WATTERS, Donald E. INGBER, Mark J. CARTWRIGHT, Michael SUPER, Martin ROTTMAN, Evangelia MURRAY, Brendon DUSEL
  • Patent number: 11112410
    Abstract: The invention relates to methods of detection, capture, isolation and targeting of cancer cells for example circulating tumor cells (CTCs) using carbohydrate recognition domain of a lectin. The invention relates to methods of diagnosis, prognosis and treatment of cancer.
    Type: Grant
    Filed: April 10, 2017
    Date of Patent: September 7, 2021
    Assignee: PRESIDENT AND FELLOWS OF HARVARD COLLEGE
    Inventors: Joo-Hun Kang, Donald E. Ingber, Michael Super, Alexander L. Watters, Harry Scott Driscoll
  • Publication number: 20210262011
    Abstract: Methods of making a three-dimensional matrix of nucleic acids within a cell is provided.
    Type: Application
    Filed: April 23, 2021
    Publication date: August 26, 2021
    Applicants: President and Fellows of Harvard College, President and Fellows of Harvard College
    Inventors: George M. Church, Jehyuk Lee, Daniel Levner, Michael Super
  • Publication number: 20210254131
    Abstract: Methods of making a three-dimensional matrix of nucleic acids within a cell is provided.
    Type: Application
    Filed: April 23, 2021
    Publication date: August 19, 2021
    Inventors: George M. Church, Jehyuk Lee, Daniel Levner, Michael Super