Abstract: A self-healing, scratch resistant slippery surface that is manufactured by wicking a chemically-inert, high-density liquid coating over a roughened solid surface featuring micro and nanoscale topographies is described. Such a slippery surface shows anti-wetting properties, as well as exhibits significant reduction of adhesion of a broad range of biological materials, including particles in suspension or solution. Specifically, the slippery surfaces can be applied to medical devices and equipment to effectively repel biological materials such as blood, and prevent, reduce, or delay coagulation and surface-mediated clot formation. Moreover, the slippery surfaces can be used to prevent fouling by microorganisms such as bacteria.

Abstract: Anti-CD19 B4 antibodies with modified variable regions are disclosed. The modified anti-CD19 variable region polypeptides have alterations to one or more framework regions or complementarity determining regions of the heavy chain variable region or light chain variable region, thereby to reduce a T-cell response.

Abstract: A system and method for removing a target species from a fluid source is provided. The system includes a reciprocating fluid cleansing device, including a processing chamber with a port at a first end for fluid passage and a movable plunger at a second end, wherein the plunger in contact with a fluid includes a motorized mixing element for mixing the fluid with species-targeting magnetic particles. Motion of the plunger in a first direction transfers a first volume of the fluid from the fluid source into the processing chamber. Motion of the plunger in a second direction transfers the first volume of the fluid from the processing chamber to a fluid destination. At least one magnetic element provides a magnetic field gradient within the processing chamber. A connector connects the port of the first processing chamber to the fluid source and the fluid destination.

Abstract: A microfluidic device of a diagnostic and detection system includes an inlet port connected by one or more microchannels to an outlet port and includes a capture and visualization chamber (CVC) connected to at least one microchannel. A fluid to be analyzed can be mixed with magnetic microbeads that have an affinity to become bound to target components, such as pathogens in the fluid. The fluid including the magnetically bound target components can be injected through the microfluidic device. Magnetic field gradient, such as provided by permanent or electro-magnets, can be applied to the fluid and the magnetically bound target components flowing through the microfluidic device to cause the magnetically bound target components to migrate into the (CVC) and become separated from the fluid.

Abstract: The present invention provides for engineered molecular opsonins that may be used to bind biological pathogens or identify subclasses or specific pathogen species for use in devices and systems for treatment and diagnosis of patients with infectious diseases, blood-borne infections or sepsis. An aspect of the invention provides for mannose-binding lectin (MBL), which is an abundant natural serum protein that is part of the innate immune system. The ability of this protein lectin to bind to surface molecules on virtually all classes of biopathogens (viruses, bacteria, fungi, protozoans) make engineered forms of MBL extremely useful in diagnosing and treating infectious diseases and sepsis.

Abstract: Anti-CD19 B4 antibodies with modified variable regions are disclosed. The modified anti-CD19 variable region polypeptides have alterations to one or more framework regions or complementarity determining regions of the heavy chain variable region or light chain variable region, thereby to reduce a T-cell response.

Abstract: This invention relates to RIM molded elastomers prepared from aliphatic isocyanurates and prepolymers thereof. The reactive systems used to prepare these elastomers exhibit longer gel times with improved flow and can still be demolded in about 30 seconds. The resultant elastomers have good weatherability without painting. This invention also relates to phase stable polyol blends.

Abstract: The present invention provides polyester-polyurethane composites made by applying a polyurethane matrix including at least one polyether containing both hydroxyl-functionality and unsaturation-functionality to an unsaturation-containing polyester matrix. Adhesion between the polyester matrix and the polyurethane matrix in the inventive composites is promoted by the polyether containing both hydroxyl-functionality and unsaturation-functionality.