Patents by Inventor Michael Sutcliffe

Michael Sutcliffe has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • RECEPTOR-SPECIFIC TUMOUR NECROSIS FACTOR-RELATED APOPTOSIS-INDUCING LIGAND (TRAIL) VARIANTS
    Publication number: 20090325867
    Abstract: The invention relates to a tumour necrosis factor- (TNF-) related apoptosis-inducing ligand (TRAIL) which is capable of selectively signalling through death receptor 4 (DR4), comprising Y at position 189. Preferably the TRAIL further comprises 19 IL and/or 199V; preferably also 201R, 213W and 215D, and/or preferably further comprises 193S. The invention also relates to uses of such TRAIL mutants which are capable of selectively signalling through DR4 in the treatment of cancer, and in the manufacture of medicaments for use in treatment of cancer. Preferably the cancer is chronic lymphocytic leukaemia, mantle cell lymphoma or non-Hodgkin's lymphoma. The invention also relates to kits comprising same.
    Type: Application
    Filed: November 29, 2006
    Publication date: December 31, 2009
    Applicants: MEDICAL RESEARCH COUNCIL, UNIVERSITY OF LEICESTER
    Inventors: Gerald Cohen, Marion MacFarlane, Michael Sutcliffe
  • Apparatus and method for forming a hemmed edge on carton blanks
    Patent number: 7137941
    Abstract: An apparatus and method for forming a hem on a 5th panel of a liquid carton blank comprising a skiving section, a stepped creaser section, a burner section, a vacuum hemmer section, and a sealer section. Carton blanks are fed into the skiver section and exit from the sealer section at a high rate of speed. The final folding step in the process is performed by a vacuum hemmer which comprises a belt with holes for pulling a vacuum to securely hold the carton blank during the second and final folding of the skived portion of the 5th panel.
    Type: Grant
    Filed: August 24, 2004
    Date of Patent: November 21, 2006
    Assignee: Folder-Gluer Technical Services Group, Inc.
    Inventors: Brian N. Gamache, Peter M. Siemiesz, Michael A. Sutcliffe, Terence Sharples
  • Apparatus and method for forming a hemmed edge on carton blanks
    Publication number: 20060046916
    Abstract: An apparatus and method for forming a hem on a 5th panel of a liquid carton blank comprising a skiving section, a stepped creaser section, a burner section, a vacuum hemmer section, and a sealer section. Carton blanks are fed into the skiver section and exit from the sealer section at a high rate of speed. The final folding step in the process is performed by a vacuum hemmer which comprises a belt with holes for pulling a vacuum to securely hold the carton blank during the second and final folding of the skived portion of the 5th panel.
    Type: Application
    Filed: August 24, 2004
    Publication date: March 2, 2006
    Inventors: Brian Gamache, Peter Siemiesz, Michael Sutcliffe, Terence Sharples
  • Process of producing a phthalocyanine pigment
    Patent number: 4158572
    Abstract: A process of producing a phthalocyanine pigment comprising dry grinding a crude phthalocyanine, stirring the ground product with an aqueous medium containing a surfactant and isolating the pigmentary product which, when dispersed into surface coating media, provide colorations having high brillance and depth of shade.
    Type: Grant
    Filed: October 11, 1977
    Date of Patent: June 19, 1979
    Assignee: Ciba-Geigy Corporation
    Inventors: John B. Blackburn, Alexander M. Irvine, Michael Sutcliffe, George McLaren