Abstract: Provided herein are methods, compositions and articles of manufacture for use in connection with cell therapy involving the administration of one or more doses of a therapeutic T cell composition. The cells of the T cell composition express recombinant receptors such as chimeric receptors, e.g. chimeric antigen receptors (CARs) or other transgenic receptors such as T cell receptors (TCRs). Features of the provided embodiments, including the numbers of cells or units of cells administered and/or the potency of administered cells, provide various advantages, such as lower risk of toxicity in subjects administered the T cell compositions.

Abstract: The present disclosure relates to systems, methods, and computer-readable media for managing a cooling system to based on dynamic power and temperature conditions of computing hardware (e.g., a system on a chip (SOC), respective hardware blocks on the SOC). For example, systems described herein involve tracking real-time power and temperature conditions of computing hardware and determining a dynamic cooling level to actuate in maintaining a desired temperature of the computing hardware. This is done in a way that preserves long-term durability of the cooling system while maintaining the ability of the cooling system to respond to a potential spike in power consumption by the computing hardware.

Abstract: A computing device is provided, including one or more processing devices, one or more temperature sensors, a fan, and a fan tachometer. The one or more processing devices may be configured to execute an application program. While executing the application program, the one or more processing devices may be further configured to collect performance data including temperature data received from the one or more temperature sensors and fan speed data received from the fan tachometer. The one or more processing devices may be further configured to generate a fan control signal at least in part by applying a machine learning model to the performance data. The one or more processing devices may be further configured to control the fan according to the fan control signal.

Abstract: A computing device is provided, including one or more processing devices, one or more temperature sensors, a fan, and a fan tachometer. The one or more processing devices may be configured to execute an application program. While executing the application program, the one or more processing devices may be further configured to collect performance data including temperature data received from the one or more temperature sensors and fan speed data received from the fan tachometer. The one or more processing devices may be further configured to generate a fan control signal at least in part by applying a machine learning model to the performance data. The one or more processing devices may be further configured to control the fan according to the fan control signal.

Abstract: A computing device is provided, including one or more processing devices, one or more temperature sensors, a fan, and a fan tachometer. The one or more processing devices may be configured to execute an application program. While executing the application program, the one or more processing devices may be further configured to collect performance data including temperature data received from the one or more temperature sensors and fan speed data received from the fan tachometer. The one or more processing devices may be further configured to generate a fan control signal at least in part by applying a machine learning model to the performance data. The one or more processing devices may be further configured to control the fan according to the fan control signal.

Abstract: Embodiments of the invention are directed to a system and method for providing a high-volume transaction queueing, reserve ecommerce solution that automatically engages and queues transactions when a primary back-end transaction processing system becomes unresponsive or unstable. Through machine learning algorithms, embodiments of the invention control transaction submission rates by queuing them and throttling the rate at which they are processed based on self-awareness and constant monitoring, feedback and health checks of the primary system. When metrics indicate that the third-party system can begin accepting transactions again, the system automatically feeds the queued transactions along with real-time orders at a rate that the third-party system can successfully manage.

Abstract: A plication lock delivery system that enables a suture lock assembly to be delivered percutaneously. The plication lock delivery system comprises a lock assembly that secures sutures in place, a control assembly that allows a clinician to engage a suture to a suture lock assembly, apply tension to the sutures to cause tissue plication, and deploy the lock assembly, and a catheter assembly. This plication lock delivery system can be used to repair mitral regurgitation percutaneously or in an open-heart surgery.

Abstract: An input device for providing input to a computing device includes a hand-held controller movable across and above a work surface. The input device includes a mouse sensor positioned on or in the hand-held controller to sense two-dimensional (2D) translation data representing translational movement of the hand-held controller across the work surface, and a six degree of freedom (6DOF) sensor positioned on or in the hand-held controller to sense 6DOF data representing position and orientation of the hand-held controller above the work surface.

Abstract: An input device for providing input to a computing device includes a hand-held controller movable across and above a work surface. The input device includes a mouse sensor positioned on or in the hand-held controller to sense two-dimensional (2D) translation data representing translational movement of the hand-held controller across the work surface, and a six degree of freedom (6DOF) sensor positioned on or in the hand-held controller to sense 6DOF data representing position and orientation of the hand-held controller above the work surface.

Abstract: An input device for providing input to a computing device includes a hand-held controller movable across and above a work surface. The input device includes a mouse sensor positioned on or in the hand-held controller to sense two-dimensional (2D) translation data representing translational movement of the hand-held controller across the work surface, and a six degree of freedom (6DOF) sensor positioned on or in the hand-held controller to sense 6DOF data representing position and orientation of the hand-held controller above the work surface.

Abstract: The present teachings provide devices and methods of treating a tricuspid valve regurgitation. Specifically, one aspect of the present teachings provides devices each includes a vascular anchor, an annulus anchor, and at least one tensioning member connecting with the vascular anchor or the annulus anchor. Another aspect of the present teachings provides methods of deploying a vascular anchor at a first treatment location inside the coronary sinus, and deploying an annulus anchor at a second treatment location across the tricuspid annulus. When both the anchors are pulled towards each other, the portion of the annulus between the two anchors is plicated, which improves the coaptation of the tricuspid valve leaflets.

Abstract: The present teachings provide devices and methods of reshaping the right heart and reducing tricuspid valve regurgitation. Specifically, one aspect of the present teachings provides an inflatable device to be deployed in the space between the sternum and the right heart. An injectable medium is injected to the cavity of the device. Once the device is filled, the device is detached from the delivery system, and released inside the body. The inflated device exerts pressure to the right heart, changes the shape of the tricuspid annulus, and allows a better coaptation of the tricuspid leaflets.

Abstract: The present teachings generally relate to translation catheter systems and method of using thereof in treating defective mitral valves. Specifically, a translation catheter system includes a catheter configured to move substantially laterally along the mitral annulus and the lateral movement of the catheter is substantially continuous and substantially adjustable. Accordingly, a method of using such a translation catheter includes advancing a first wire across the mitral annulus at a first treatment location, delivering a catheter at or near the first treatment location, moving the catheter substantially laterally to a second treatment location, and advancing a second wire across the mitral annulus, where the distance between the first and second treatment locations is substantially adjustable and optionally visualized.

Abstract: Example implementations relate to establishing communication Sinks with electronic devices. As an example, a computing device includes a data acquisition device to obtain global unique identifier (GUID) of an electronic device using a first communication protocol. The computing device also includes a processor to authenticate the electronic device based on the GUiD. The processor is also to determine device characteristic information associated with the electronic device based on the GUID. The processor is further to establish a communication link with the electronic device based on the device characteristic information and the GUID, The communication link is implemented based on a second communication protocol that is different from the first communication protocol.

Abstract: A plication lock delivery system that enables a suture lock assembly to be delivered percutaneously. The plication lock delivery system comprises a lock assembly that secures sutures in place, a control assembly that allows a clinician to engage a suture to a suture lock assembly, apply tension to the sutures to cause tissue plication, and deploy the lock assembly, and a catheter assembly. This plication lock delivery system can be used to repair mitral regurgitation percutaneously or in an open-heart surgery.

Abstract: A plication lock delivery system that enables a suture lock assembly to be delivered percutaneouly. The plication lock delivery system comprises a lock assembly that secures sutures in place, a control assembly that allows a clinician to engage a suture to a suture lock assembly, apply tension to the sutures to cause tissue plication, and deploy the lock assembly, and a catheter assembly. This plication lock delivery system can be used to repair mitral regurgitation percutaneouly or in an open-heart surgery.

Abstract: Example implementations relate to establishing communication Sinks with electronic devices. As an example, a computing device includes a data acquisition device to obtain global unique identifier (GUID) of an electronic device using a first communication protocol. The computing device also includes a processor to authenticate the electronic device based on the GUiD. The processor is also to determine device characteristic information associated with the electronic device based on the GUID. The processor is further to establish a communication link with the electronic device based on the device characteristic information and the GUID, The communication link is implemented based on a second communication protocol that is different from the first communication protocol.

Abstract: The present teachings provide devices and methods of treating a tricuspid valve regurgitation. Specifically, one aspect of the present teachings provides devices and methods for reshaping and resizing the right ventricle by reducing the distances between two papillary muscles. Another aspect of the present teachings provides devices and methods for reshaping and resizing the right ventricle by reducing the distances along the right ventricle wall. Another aspect of the present teachings provides devices and methods for reshaping and resizing the right ventricle by reducing the distance between the distance of right ventricle outflow track and the right ventricle wall. Another aspect of the present teachings provides devices and methods for reshaping and resizing the right ventricle by changing the right ventricle sphericity index. Another aspect of the present teachings provides devices and methods for reshaping and resizing the right ventricle by reducing the tricuspid valve tethering height.

Abstract: The present teachings generally relate to translation catheter systems and method of using thereof in treating defective mitral valves. Specifically, a translation catheter system includes a catheter configured to move substantially laterally along the mitral annulus and the lateral movement of the catheter is substantially continuous and substantially adjustable. Accordingly, a method of using such a translation catheter includes advancing a first wire across the mitral annulus at a first treatment location, delivering a catheter at or near the first treatment location, moving the catheter substantially laterally to a second treatment location, and advancing a second wire across the mitral annulus, where the distance between the first and second treatment locations is substantially adjustable and optionally visualized.

Abstract: The present teachings provide devices and methods of treating a tricuspid valve regurgitation. Specifically, one aspect of the present teachings provides devices and methods for reshaping and resizing the right ventricle by reducing the distances between two papillary muscles. Another aspect of the present teachings provides devices and methods for reshaping and resizing the right ventricle by reducing the distances along the right ventricle wall. Another aspect of the present teachings provides devices and methods for reshaping and resizing the right ventricle by reducing the distance between the distance of right ventricle outflow track and the right ventricle wall. Another aspect of the present teachings provides devices and methods for reshaping and resizing the right ventricle by changing the right ventricle sphericity index. Another aspect of the present teachings provides devices and methods for reshaping and resizing the right ventricle by reducing the tricuspid valve tethering height.