Abstract: A surgical stapler, or fastening instrument, may generally comprise a layer, such as a tissue thickness compensator, for example, releasably attached to a fastener cartridge and/or anvil by a flowable attachment portion. The flowable attachment portion may be indefinitely flowable. The flowable attachment portion may be flowable from the time that layer is installed to the fastener cartridge to the time in which the layer is implanted to patient tissue. The flowable attachment portion may comprise a pressure sensitive adhesive. The flowable attachment portion may comprise an adhesive laminate comprising a base layer comprising the tissue thickness compensator and an adhesive layer on at least a portion of a surface of the base layer comprising the pressure sensitive adhesive. Articles of manufacture comprising flowable attachment portion and methods of making and using the flowable attachment portion are also described.

Abstract: A fastener cartridge can comprise, one, a cartridge body configured to at least partially store a plurality of fasteners therein and, two, a layer of material attached to the cartridge body by a retention member. The retention member can be deactivated to release the layer from the cartridge body when a firing member is moved through the cartridge body to eject the fasteners from the cartridge body. The retention member can be deactivated at the beginning, the end, and/or at any suitable time during a firing stroke of the firing member. Certain fastener cartridges can comprise a plurality of retention members configured to releasably hold the layer to the cartridge body. In certain circumstances, the retention members can be sequentially released in order to progressively release the layer.