Abstract: Formulations of compounds of Formula I are provided as are doses and dosing regimens useful in methods of treating cancer including hematological malignances such as acute myelogenous leukemia, multiple myeloma, and non-Hodgkin's lymphoma.

Abstract: This disclosure features gastro-retentive (GR) modified release pharmaceutical dosage forms (e.g., solid dosage forms, e.g., tablets, e.g., bilayer tablets) that are useful for the oral administration of oprozomib, or a pharmaceutically acceptable salt thereof, to a human or animal subject as well as methods of making and using the dosage form.

Abstract: A children's luggage device stores and carries items in a device that is appealing to children and can be used for amusement while traveling. The device includes a container having a bottom wall and a perimeter wall coupled to and extending upwardly from the bottom wall to define an interior space. A cover is coupled to the container such that the cover selectively covers the interior space. An exterior surface of the container and the cover is shaped to resemble a vehicle when the cover is in a closed position. Each of a plurality of wheels is coupled to the container.

Abstract: An apparatus and a method for removing a hip socket liner from surface attachment to a socket, that includes providing a carrier and multiple penetrators carried to be displaced relative to the carrier, inserting the carrier in the liner so that the penetrators project toward a liner cup-shaped surface, effecting controlling limited forceful displacement of tips defined by the penetrators toward and into said liner cup-shaped surface, and transmitting pushing force acting between the carrier and hip socket whereby the liner is suddenly freed from attachment to the socket.

Abstract: The method of removing a hip socket liner from surface attachment to a socket, that includes providing a carrier and multiple penetrators carried to be displaced relative to the carrier, inserting the carrier in the liner so that the penetrators project toward a liner cup-shaped surface, effecting controlling limited forceful displacement of tips defined by the penetrators toward and into said liner cup-shaped surface, and transmitting pushing force acting between the carrier and hip socket whereby the liner is suddenly freed from attachment to the socket.

Abstract: The method of accurately and correctly fitting and axially positioning at implantable ball to the neck trunnion of a hip replacement device, as during surgery, the ball adapted to be received in a socket, the ball having a bore, the method including the steps providing the neck trunnion with deformable metallic surface ribs, providing a deformable adapter and fitting the adapter over the ribs, providing a trial ball having a non-metallic bore, and including axially forcibly fitting that bore over the deformable adapter to deform the adapter without deforming the ribs, as the trial ball adjustingly arrives at selected axial position on the neck trunnion corresponding to correct position of the trial ball in the socket, and correspondingly subsequent correct axial positioning of the implantable ball on the neck trunnion.

Abstract: The method of accurately and correctly fitting and axially positioning at implantable ball to the neck trunnion of a hip replacement device, as during surgery, the ball adapted to be received in a socket, the ball having a bore, the method including the step providing the neck trunnion with deformable metallic surface ribs, providing a deformable adapter and fitting the adapter over the ribs, providing a trial ball having a non-metallic bore, and including axially forcibly fitting that bore over the deformable adapter to deform the adapter without deforming the ribs, as the trial ball adjustingly arrives at selected axial position on the neck trunnion corresponding to correct position of the trial ball in the socket, and correspondingly subsequent correct axial positioning of the implantable ball on the neck trunnion.

Abstract: The present invention provides compositions and methods of preparing a bilayer structure for encapsulating multiple containment units. These containment units can contain therapeutic, diagnostic agents or imaging agents that can be released through the bilayer structure. A suitable example of such a containment unit is a unilamellar or multilamellar vesicle.

Abstract: The present invention provides compositions and methods of preparing a bilayer structure for encapsulating multiple containment units. These containment units can contain therapeutic, diagnostic agents or imaging agents that can be released through the bilayer structure. A suitable example of such a containment unit is a unilamellar or multilamellar vesicle.

Abstract: Losartan potassium is an angiotensin II antagonist useful in the treatment of hypertension and congestive heart failure. ##STR1## This invention relates to the process for the controlled crystallization of losartan potassium utilizing anti-solvent addition combined with massive seeding in order to obtain the desired crystal morphology and bulk physical properties necessary for successful formulation.