Abstract: Described herein are compositions and methods for signaling and antigen-presenting bifunctional receptors (SABRs) comprising one or more antigen presenting domains; and one or more signal transduction domains, wherein the one or more antigen presenting domains comprise a binding fragment of a major histocompatibility complex (MHC) molecule. Various immunological functions of the SABRs are also described.

Abstract: Described herein are modified bacteriophage serine integrases that function in mammalian cells. Also described herein are landing pad architectures. Engineered cells comprising these integrases and landing pads are also described, which facilitate site-specific genomic integration of pay load molecules.

Abstract: Disclosed herein are cell genetically engineered cell for AAV production. The genetically engineered cell comprises molecular systems for temporal control of expression of genes required for AAV production. Also disclosed herein are methods of using genetically engineered cells for AAV production.

Abstract: Disclosed herein are cell genetically engineered cell for AAV production. The genetically engineered cell comprises molecular systems for temporal control of expression of genes required for AAV production. Also disclosed herein are methods of using genetically engineered cells for AAV production.

Abstract: Described herein are compositions and methods for signaling and antigen-presenting bifunctional receptors (SABRs) comprising one or more antigen presenting domains; and one or more signal transduction domains, wherein the one or more antigen presenting domains comprise a binding fragment of a major histocompatibility complex (MHC) molecule. Various immunological functions of the SABRs are also described.

Abstract: A system for remote adjusting of guide rail positions along a conveyor. The guide rails are adjusted to allow the conveyor to accommodate product packages of various shapes and sizes. A moveable guide rail assembly is positioned along a conveyor and is in mechanical connection with the piston rod of an actuator cylinder. A guide rail control device is fluidly connected with the actuator cylinder and it translates a mechanical input to a fluidic output that is communicated with the piston of the actuator cylinder to thereby move the guide rail assembly into a new adjustment position. The system can provide simultaneous adjustment of numerous guard rail segments from a remote guide rail control device while providing accurate non-drift infinitely-adjustable positioning.