Patents by Inventor Michael T. Longaker

Michael T. Longaker has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20200253899
    Abstract: Methods of increasing perfusion and vascularity in irradiated tissue and of increasing retention of fat cells in a fat graft in irradiated tissue by applying an effective amount of DFO to the irradiated tissue at a treatment site. The DFO may be administered transdermally by applying a transdermal delivery device to a tissue surface at the treatment site in multiple discrete doses. The transdermal delivery system comprises DFO encapsulated in reverse micelles.
    Type: Application
    Filed: September 12, 2018
    Publication date: August 13, 2020
    Applicant: THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
    Inventors: Derrick C. WAN, Geoffrey C. GURTNER, Michael T. LONGAKER
  • Patent number: 10561359
    Abstract: Devices, kits, systems and methods are described herein for treatment to skin, including but not limited to wound healing, the treatment, amelioration, and/or prevention of scars or keloids. Certain devices kits, systems and methods are used to select treatment parameters, devices or methods for treating skin in a location, zone, or region of skin having particular mechanical or other properties.
    Type: Grant
    Filed: March 8, 2013
    Date of Patent: February 18, 2020
    Assignee: Neodyne Biosciences, Inc.
    Inventors: Jasper Jackson, John A. Zepeda, Michael T. Longaker, Reinhold H. Dauskardt, Kemal Levi, William R. Beasley
  • Publication number: 20190336575
    Abstract: Methods and compositions are provided for the therapeutic use of hedgehog agents, for enhancing bone growth and regeneration in diabetic or pre-diabetic patients, including repair following injury, osseointegration of implants, and the like. In some embodiments of the invention, the compositions are administered locally, e.g. by injection or implantation at the site of an injury.
    Type: Application
    Filed: January 8, 2018
    Publication date: November 7, 2019
    Inventors: Michael T. Longaker, Irving L. Weissman, Ruth Tevlin, Charles K.F. Chan
  • Publication number: 20190183940
    Abstract: Methods, compositions, and kits for producing functional blood vessels, and progenitors thereof are provided. Human disorders of the vascular system are treated by reconstitution of functional vessels in vivo through co-transplantation with supporting niche stromal cells for treatment of ischemic injury in the peripheral limbs and heart. The cell populations of the invention, when engrafted into a recipient, anastomose with host vasculature and regenerate functional blood vessels.
    Type: Application
    Filed: August 25, 2017
    Publication date: June 20, 2019
    Inventors: Charles K.F. Chan, Andrew Stephen Lee, Michael T. Longaker, Irving L. Weissman, Joseph Wu, Divya Nag, Eun Young Seo
  • Publication number: 20190015255
    Abstract: The methods, procedures, kits, and devices described herein assist with the healing process of tissue that was previously or simultaneously treated for a therapeutic or cosmetic effect. The methods, procedures, kits, and devices described herein can also provide temporary simulated results of a cosmetic procedure to allow for visual assessment to select the type of procedure or for treatment planning in advance of the surgical procedure.
    Type: Application
    Filed: July 3, 2018
    Publication date: January 17, 2019
    Inventors: Geoffrey C. GURTNER, Michael T. LONGAKER, Reinhold H. DAUSKARDT, Paul YOCK, John A. ZEPEDA, Kenneth N. HORNE, Bankim H. MEHTA, Michael H. ROSENTHAL, Joseph RIMSA, Sergio SALINAS, Melanie HARRIS, Greg SPOONER, Kin CHAN
  • Publication number: 20180360669
    Abstract: Devices, bandages, kits and methods are described that can control or regulate the mechanical environment of a wound to ameliorate scar and/or keloid formation. The mechanical environment of a wound includes stress, strain, and any combination of stress and strain. The control of a wound's mechanical environment can be active, passive, dynamic, or static. The devices are configured to be removably secured to a skin surface in proximity to the wound site and shield the wound from endogenous and/or exogenous stress.
    Type: Application
    Filed: February 6, 2018
    Publication date: December 20, 2018
    Inventors: Geoffrey C. GURTNER, Reinhold H. DAUSKARDT, Michael T. LONGAKER, Paul YOCK
  • Patent number: 9889046
    Abstract: Devices, bandages, kits and methods are described that can control or regulate the mechanical environment of a wound to ameliorate scar and/or keloid formation. The mechanical environment of a wound includes stress, strain, and any combination of stress and strain. The control of a wound's mechanical environment can be active, passive, dynamic, or static. The devices are configured to be removably secured to a skin surface in proximity to the wound site and shield the wound from endogenous and/or exogenous stress.
    Type: Grant
    Filed: January 20, 2016
    Date of Patent: February 13, 2018
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Geoffrey C. Gurtner, Reinhold H. Dauskardt, Michael T. Longaker, Paul Yock
  • Publication number: 20170360838
    Abstract: Methods, compositions and kits for producing functional chondrocytes, skeletal cells, bone marrow stromal cells, and progenitor cells thereof are provided. These methods, compositions and kits find use in producing chondrocytes, osteoblasts, stromal cells, and progenitor cells thereof in vivo, or in vitro for transplantation, for experimental evaluation, as a source of lineage- and cell-specific products, and the like, for example for use in treating human disorders of the cartilage, bone and hematopoietic system. In some embodiments, specific combinations of protein factors are identified for reprogramming non-skeletal cells into bones, hematopoietic stroma, and chondrocytes, which may be provided in vitro or in vivo.
    Type: Application
    Filed: January 6, 2016
    Publication date: December 21, 2017
    Inventors: Charles K.F. Chan, Irving L. Weissman, Michael T. Longaker
  • Patent number: 9827447
    Abstract: Devices, kits, systems and methods described herein may be for treatment to skin, including but not limited to wound healing, the treatment, amelioration, and/or prevention of scars or keloids. Devices kits, systems and methods described herein may be used to select treatment parameters or devices for treating skin in a zone or region of skin having particular mechanical or other properties.
    Type: Grant
    Filed: November 30, 2012
    Date of Patent: November 28, 2017
    Assignee: Neodyne Biosciences, Inc.
    Inventors: Kemal Levi, Jasper Jackson, John A. Zepeda, William R. Beasley, Reinhold H. Dauskardt, Michael T. Longaker
  • Publication number: 20170157296
    Abstract: Compositions and methods are provided for enhanced healing of wounds, e.g. cutaneous wounds, by application of a scaffold or matrix, e.g. a hydrogel film comprising a dose of macrophages, or monocyte progenitors thereof, which dose is effective in increasing the rate of wound healing. The compositions of the invention find use in treating cutaneous wounds, particularly chronic wounds, e.g. in diabetic patients or other patients with impaired wound healing.
    Type: Application
    Filed: July 20, 2015
    Publication date: June 8, 2017
    Inventors: Graham G. Walmsley, Kipp Andrew Weiskopf, Michael Sung-Min Hu, Michael T. Longaker, Irving L. Weissman, Geoffrey C. Gurtner, Jayakumar Rajadas
  • Patent number: 9655967
    Abstract: The formation of scars at a wound site is reduced by contacting the wound site with an effective dose of an inhibitor of focal adhesion kinase (FAK) activity or expression. Blockade of FAK is sufficient to prevent mechanical and inflammatory stimuli from activating MCP-1 pathways. In addition to these chemokine-mediated mechanisms, inhibition of FAK may control fibrosis by blocking fibroblast collagen production. Pharmacologic blockade of FAK significantly reduces scar formation in vivo.
    Type: Grant
    Filed: December 5, 2012
    Date of Patent: May 23, 2017
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Geoffrey C. Gurtner, Michael T. Longaker, Victor W. Wong
  • Publication number: 20170112673
    Abstract: Devices, kits and methods described herein may be for wound healing, including but not limited to the treatment, amelioration, or prevention of scars and/or keloids. The packaging, manipulation elements, applicator and/or tensioning device maybe used to apply and/or maintain a strain in an elastic dressing.
    Type: Application
    Filed: July 29, 2016
    Publication date: April 27, 2017
    Inventors: Jasper JACKSON, John A. ZEPEDA, Geoffrey C. GURTNER, William R. BEASLEY, Paul YOCK, Keiichiro ICHIRYU, Manuel A. CARDONA PAMPLONA, Tor C. KROG, Kemal LEVI, Michael T. LONGAKER, Reinhold H. DAUSKARDT, Michael T. CAO, Rene RODRIGUEZ
  • Publication number: 20170058263
    Abstract: Human somatic cells obtained from individuals with a genetic heart condition are reprogrammed to become induced pluripotent stem cells (iPS cells), and differentiated into cardiomyocytes for use in analysis, screening programs, and the like.
    Type: Application
    Filed: June 10, 2016
    Publication date: March 2, 2017
    Inventors: Ning Sun, Michael T. Longaker, Robert C. Robbins, Joseph Wu, Feng Lan, Andrew Stephen Lee, Paul W. Burridge
  • Publication number: 20160213522
    Abstract: Devices, bandages, kits and methods are described that can control or regulate the mechanical environment of a wound to ameliorate scar and/or keloid formation. The mechanical environment of a wound includes stress, strain, and any combination of stress and strain. The control of a wound's mechanical environment can be active, passive, dynamic, or static. The devices are configured to be removably secured to a skin surface in proximity to the wound site and shield the wound from endogenous and/or exogenous stress.
    Type: Application
    Filed: January 20, 2016
    Publication date: July 28, 2016
    Applicant: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Geoffrey C. Gurtner, Reinhold H. Dauskardt, Michael T. Longaker, Paul Yock
  • Patent number: 9395354
    Abstract: Human somatic cells obtained from individuals with a genetic heart condition are reprogrammed to become induced pluripotent stem cells (iPS cells), and differentiated into cardiomyocytes for use in analysis, screening programs, and the like.
    Type: Grant
    Filed: July 20, 2012
    Date of Patent: July 19, 2016
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Ning Sun, Michael T. Longaker, Robert C. Robbins, Joseph Wu, Feng Lan, Andrew Stephen Lee, Paul W. Burridge
  • Patent number: 9248051
    Abstract: Devices, bandages, kits and methods are described that can control or regulate the mechanical environment of a wound to ameliorate scar and/or keloid formation. The mechanical environment of a wound includes stress, strain, and any combination of stress and strain. The control of a wound's mechanical environment can be active, passive, dynamic, or static. The devices are configured to be removably secured to a skin surface in proximity to the wound site and shield the wound from endogenous and/or exogenous stress.
    Type: Grant
    Filed: March 7, 2013
    Date of Patent: February 2, 2016
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Geoffrey C. Gurtner, Reinhold H. Dauskardt, Michael T. Longaker, Paul Yock
  • Patent number: 9248049
    Abstract: Devices, bandages, kits and methods are described that can control or regulate the mechanical environment of a wound to ameliorate scar and/or keloid formation. The mechanical environment of a wound includes stress, strain, and any combination of stress and strain. The control of a wound's mechanical environment can be active, passive, dynamic, or static. The devices are configured to be removably secured to a skin surface in proximity to the wound site and shield the wound from endogenous and/or exogenous stress.
    Type: Grant
    Filed: April 18, 2011
    Date of Patent: February 2, 2016
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Geoffrey C. Gurtner, Reinhold H. Dauskardt, Michael T. Longaker, Paul Yock
  • Publication number: 20150184131
    Abstract: Human somatic cells are reprogrammed to become induced pluripotent stem cells (iPS cells) by the introduction of a minicircle DNA vector. Cells of interest include adipose stem cells.
    Type: Application
    Filed: January 6, 2015
    Publication date: July 2, 2015
    Inventors: Joseph Wu, Michael T. Longaker, Mark A. Kay, Ning Sung, FangJun Jia, Zhi-Ying Chen, Nicholas Panetta, Deepak Gupta
  • Patent number: 8962331
    Abstract: Human somatic cells are reprogrammed to become induced pluripotent stem cells (iPS cells) by the introduction of a minicircle DNA vector. Cells of interest include adipose stem cells.
    Type: Grant
    Filed: February 1, 2011
    Date of Patent: February 24, 2015
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Joseph Wu, Michael T. Longaker, Mark A. Kay, Ning Sung, FangJun Jia, Zhi-Ying Chen, Nicholas Panetta, Deepak Gupta
  • Patent number: 8608760
    Abstract: Disclosed are compositions, methods, and kits for joining together non-conjoined lumens in a patient's body including vascular lumens. More particularly, in various aspects, this invention provides compositions, methods, and kits for joining such non-conjoined lumens, including small lumens typically requiring microsurgical technique.
    Type: Grant
    Filed: December 20, 2007
    Date of Patent: December 17, 2013
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Geoffrey C. Gurtner, Gerald G. Fuller, Michael T. Longaker, Jayakumar Rajadas, Gordon Saul, C. Travis Rappleye, Evgenia Mandrusov