Abstract: The present invention is directed to urea compounds which are agonists of orexin receptors. The present invention is also directed to uses of the compounds described herein in the potential treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The present invention is also directed to compositions comprising these compounds. The present invention is also directed to uses of these compositions in the potential prevention or treatment of such diseases in which orexin receptors are involved.

Abstract: Structural elements of biocompatible material are interlocked with one another in an array to repair, augment or replace natural bone, the structural elements each including a hub having a center, and a plurality of posts projecting from the hub and spaced from one another to establish inter-post spaces between adjacent posts, each post having a root at the hub, an opposite tip, a length, and a transverse cross-sectional configuration, the number of posts and the relative length, cross-sectional configuration, and location of adjacent posts in each structural element being such that the inter-post spaces of one structural element will receive the posts of adjacent structural elements in the array to promote interlocking of adjacent structural elements in a relatively tightly meshed relationship for resisting shear stress in essentially all directions within the array.

Abstract: An apparatus for obtaining a core sample includes an elongate guide pin and a hollow drill element. The drill element has an open front end provided with a cutting edge and an open rear end provided with an axial engagement structure for engaging an associated driving tool. A longitudinal aperture extends from the front end of the drill element to the rear end with the aperture having a smooth uninterrupted interior periphery throughout at least a major portion of its length. A spacer slug is adapted to be positioned in the drill element longitudinal aperture. The spacer slug has a centrally disposed aperture extending longitudinally therethrough and sized so that the guide pin can extend therethrough. The spacer slug has a suitable outer diameter so that it can slide in the drill element longitudinal aperture.

Abstract: Apparatus for analyzing the force acting on the human foot comprises television cameras for photographing the gait of the subject and for photographing the plantar surface of his foot through a transparent platform. The platform comprises a plurality of beams each of which is supported at each end by means for detecting the load imposed on each beam. The video outputs of the two cameras and the load on each beam are displayed on a monitor screen. The apparatus also includes circuitry for determining from the loads on the ends of the beam where the center of pressure is on each beam. These centers of pressure are displayed superimposed on the image of the plantar surface.