Abstract: The present invention is directed to cinnolinyl and quinolinyl pyrazol-4-yl-pyridine compounds which are allosteric modulators of the M4 muscarinic acetylcholine receptor. The present invention is also directed to uses of the compounds described herein in the potential treatment or prevention of neurological and psychiatric disorders and diseases in which M4 muscarinic acetylcholine receptors are involved. The present invention is also directed to compositions comprising these compounds. The present invention is also directed to uses of these compositions in the potential prevention or treatment of such diseases in which M4 muscarinic acetylcholine receptors are involved.

Abstract: Provided herein are compounds, compositions, and methods useful for modulating the integrated stress response (ISR) and for treating related diseases; disorders and conditions.

Abstract: The present invention relates to novel Amido-Substituted Heterocycle Compounds of Formula (I): and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, and R5 are as defined herein. The present invention also relates to compositions comprising at least one Amido-Substituted Heterocycle Compounds for treating or preventing a herpesvirus infection in a patient.

Abstract: The present invention features solid pharmaceutical compositions comprising Compound 1 and Compound 2. In one embodiment, the solid pharmaceutical composition includes (1) a first layer which comprises 100 mg Compound 1, as well as a pharmaceutically acceptable hydrophilic polymer and a pharmaceutically acceptable surfactant, all of which are formulated in amorphous solid dispersion; and (2) a second layer which comprises 40 mg Compound 2, as well as a pharmaceutically acceptable hydrophilic polymer and a pharmaceutically acceptable surfactant, all of which are formulated in amorphous solid dispersion.

Abstract: The present invention relates to novel Amido-Substituted Heterocycle Compounds of Formula (I): and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, R7, and R8 are as defined herein. The present invention also relates to compositions comprising at least one Amido-Substituted Heterocycle Compound, and methods of using the Amido-Substituted Heterocycle Compounds for treating or preventing a herpesvirus infection in a patient.

Abstract: An endoscope manipulator for performing robot-assisted endoscope manipulation comprises a movable robot base with a hollow trunk and a vertical lifting joint; a passive joint set with one end mounted to an upper end of the vertical lifting joint, for manually setting an initial pose of the endoscope; an active joint set mounted to another end of the passive joint set, for adjusting pose control of the endoscope intra-operatively; and a compliant endoscope holder mountable to an end-effector of the active joint set, which passively changes to a compliant state upon an external force exceeding a threshold being applied to an endoscopic lens held by the compliant endoscope holder.

Abstract: Exemplary systems and methods are directed to generating synthetic data for computer vision. A processing device generates a synthetic three-dimensional (3D) image of an object. A background image is selected, and a composite image is generated by combining the 3D image of the object and the background image. The processing device simulates: reflection or emission of at least one type of radiant energy from the surface of the object and/or the background according to a set of parameters associated with at least one of the object and the background image; and a reflectance or emittance measurement of the at least one type of radiant energy from the surface of the object by a sensor device configured for detecting the at least one type of radiant energy. The processing device generates a plurality of two-dimensional (2D) simulated images of different perspectives of the object based on simulation data.

Abstract: A computer-implemented method for assessing an image sentiment. The method can include receiving an image to identify a region of interest in the image; determining an image sentiment value associated with the image based on the region of interest, or a classification of the image; and displaying an indication of the image sentiment value with a spatial (e.g. geographical) location.

Abstract: A computer-implemented method for assessing an image sentiment. The method can include receiving an image to identify a region of interest in the image; determining an image sentiment value associated with the image based on the region of interest, or a classification of the image; and displaying an indication of the image sentiment value with a spatial (e.g. geographical) location.

Abstract: An endoscope manipulator for performing robot-assisted endoscope manipulation comprises a movable robot base with a hollow trunk and a vertical lifting joint; a passive joint set with one end mounted to an upper end of the vertical lifting joint, for manually setting an initial pose of the endoscope; an active joint set mounted to another end of the passive joint set, for adjusting pose control of the endoscope intra-operatively; and a compliant endoscope holder mountable to an end-effector of the active joint set, which passively changes to a compliant state upon an external force exceeding a threshold being applied to an endoscopic lens held by the compliant endoscope holder.

Abstract: An automatic distress alarming method includes that: A. a distress alarm automatically sends out a sound and light alarming signal; B. the distress alarm automatically sends a distress signal and a GPS signal to a mobile phone; C. the distress alarm sends out the distress signal and the GPS signal by a manual operation; D. a disconnected distress alarm sends out the distress signal and the GPS signal. And its system includes a microprocessor U1, a driving chip U2, a wireless transmitting module U3, a switching circuit of an angular rate sensor, a GPS circuit, a storage device, a reset button, a manual operation alarming switch, a manual operation communicating switch and a disconnecting alarming button.

Abstract: An automatic distress alarming method includes that: A. a distress alarm automatically sends out a sound and light alarming signal; B. the distress alarm automatically sends a distress signal and a GPS signal to a mobile phone; C. the distress alarm sends out the distress signal and the GPS signal by a manual operation; D. a disconnected distress alarm sends out the distress signal and the GPS signal. And its system includes a microprocessor U1, a driving chip U2, a wireless transmitting module U3, a switching circuit of an angular rate sensor, a GPS circuit, a storage device, a reset button, a manual operation alarming switch, a manual operation communicating switch and a disconnecting alarming button.