Patents by Inventor Michael T. Taylor

Michael T. Taylor has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 6576476
    Abstract: A device for detecting chemiluminescence from a sample. The device may include a stage for supporting a sample and one or more of the following elements: (1) an optics head, (2) an optical relay structure for transmitting chemiluminescence from the sample to a detector, (3) a drive mechanism, (4) a sensor for detecting proximity of the optical relay structure to the sample, (5) a mask structure for selecting an effective diameter of the optical relay structure, and (6) a baffle for blocking extraneous light from entering the optical relay structure.
    Type: Grant
    Filed: April 29, 1999
    Date of Patent: June 10, 2003
    Assignee: LJL BioSystems, Inc.
    Inventors: Michael T. Taylor, Amer El-Hage, Glenn R. Edwards, Douglas N. Modlin
  • Publication number: 20030066915
    Abstract: An apparatus for disrupting cells or viruses comprises a container having a chamber for holding the cells or viruses. The chamber is defined by at least one wall having an external surface for contacting a transducer device. The transducer device has a vibrating surface for contacting the wall and for vibrating at an operating frequency and amplitude sufficient to generate pressure waves or pressure pulses in the chamber. The transducer device is coupled to the wall with a preload force sufficient to create a stress within the wall. The natural frequency of the wall, when the wall is stressed by the preload force, is equal to the operating frequency of the transducer device or differs from the operating frequency by less than 50% of the operating frequency.
    Type: Application
    Filed: October 4, 2001
    Publication date: April 10, 2003
    Applicant: Cepheid
    Inventor: Michael T. Taylor
  • Publication number: 20020187547
    Abstract: A container for holding cells or viruses for disruption comprises a chamber defined by two spaced apart, opposing major walls and side walls connecting the major walls to each other. At least one of the major walls has an external surface to which the transducer may be coupled and is sufficiently flexible to flex in response to vibratory motion of the transducer. The container also has at least one port for introducing the cells or viruses into the chamber. In some embodiments, the chamber contains beads for aiding the disruption of the cells or viruses.
    Type: Application
    Filed: July 30, 2002
    Publication date: December 12, 2002
    Applicant: Cepheid
    Inventors: Michael T. Taylor, Phillip Belgrader, Farzad Pourahmadi, William A. McMillan, Ronald Chang, Douglas B. Dority
  • Patent number: 6431476
    Abstract: The present invention provides an apparatus and method for disrupting cells or viruses to release the nucleic acid therefrom. The apparatus includes a container having a chamber for holding the cells or viruses. The apparatus also includes an ultrasonic transducer for contacting a wall of the chamber and for transmitting ultrasonic energy into the chamber through the wall. A support structure holds the container and the transducer against each other such that the transducer contacts the wall of the chamber. The support structure includes an elastic body, such as a spring, for applying to the container or to the transducer a substantially constant force to press together the transducer and the wall. The chamber also preferably contains beads for enhancing the disruption of the cells or viruses. The apparatus performs rapid and consistent lysis of cells or viruses, often in as little time as 5 to 10 seconds.
    Type: Grant
    Filed: December 21, 1999
    Date of Patent: August 13, 2002
    Assignee: Cepheid
    Inventors: Michael T. Taylor, Phillip Belgrader, Farzad Pourahmadi, William A. McMillan, Ronald Chang, Douglas B. Dority
  • Patent number: 6391541
    Abstract: A cartridge for separating a desired analyte from a fluid sample has a sample flow path and a lysing chamber in the sample flow path. The lysing chamber contains at least one filter for capturing cells or viruses from the sample as the sample flows through the lysing chamber. Beads are also disposed in the lysing chamber for rupturing the cells or viruses to release the analyte therefrom. An analyte flow path extends from the lysing chamber and diverges from the sample flow path. The analyte flow path preferably leads to a reaction chamber for chemically reacting and optically detecting the analyte. The cartridge also includes at least one flow controller (e.g., valves) for directing the sample into the waste chamber after the sample flows through the lysing chamber and for directing the analyte separated from the sample into the analyte flow path.
    Type: Grant
    Filed: May 30, 2000
    Date of Patent: May 21, 2002
    Inventors: Kurt E. Petersen, Michael T. Taylor, Farzad Pourahmadi, William A. McMillan, Ronald Chang, Stanley H. Sakai, Jesus Ching, Douglas B. Dority, Phillip Belgrader, M. Allen Northrup
  • Publication number: 20020019060
    Abstract: The present invention provides a cartridge for analyzing a fluid sample. The cartridge provides for the efficient separation of cells or viruses in the sample from the remaining sample fluid, lysis of the cells or viruses to release the analyte (e.g., nucleic acid) therefrom, and optionally chemical reaction and/or detection of the analyte. The cartridge is useful in a variety of diagnostic, life science research, environmental, or forensic applications for determining the presence or absence of one or more analytes in a sample.
    Type: Application
    Filed: October 2, 2001
    Publication date: February 14, 2002
    Applicant: Cepheid
    Inventors: Kurt E. Petersen, Michael T. Taylor, Farzad Pourahmadi, William A. McMillan, Ronald Chang, Stanley H. Sakai, Jesus Ching, Douglas B. Dority, Phillip Belgrader, M. Allen Northrup
  • Patent number: 6313960
    Abstract: Devices for using optical filters in a filter holder that enable optical filters to be simply, conveniently, and flexibly interchanged.
    Type: Grant
    Filed: July 16, 1998
    Date of Patent: November 6, 2001
    Assignee: LJL Biosystems, Inc.
    Inventors: Samuel A. Marquiss, Calvin D. Wong, Glenn R. Edwards, Michael T. Taylor, Philip A. Granieri, Jr., Douglas N. Modlin, Amer El-Hage
  • Publication number: 20010021074
    Abstract: Devices for using optical filters in a filter holder that enable optical filters to be simply, conveniently, and flexibly interchanged.
    Type: Application
    Filed: July 16, 1998
    Publication date: September 13, 2001
    Inventors: SAMUEL A. MARQUISS, CALVIN D. WONG, GLENN R. EDWARDS, MICHAEL T. TAYLOR, PHIL A. GARNIERI, DOUGLAS N. MODLIN, AMER EL-HAGE
  • Publication number: 20010012612
    Abstract: A method for separating a desired analyte from a fluid sample comprises the steps of introducing the sample into a cartridge having a sample flow path and a lysing chamber in the sample flow path. The lysing chamber contains at least one filter for separating cells or viruses from the sample. The sample is forced to flow through the sample flow path, thereby capturing the cells or viruses with the filter as the sample flows through the chamber. The ratio of the volume of sample forced to flow through the chamber to the volume capacity of the chamber is preferably at least 2:1, and the volume of sample forced to flow through the chamber is preferably at least 100 microliters. The captured cells or viruses are disrupted to release the analyte therefrom, and the analyte is eluted from the chamber.
    Type: Application
    Filed: March 6, 2001
    Publication date: August 9, 2001
    Applicant: Cepheid
    Inventors: Kurt E. Petersen, Michael T. Taylor, Farzad Pourahmadi, William A. McMillan, Ronald Chang, Stanley H. Sakai, Jesus Ching, Douglas B. Dority, Phillip Belgrader, M. Allen Northrup
  • Patent number: 6187267
    Abstract: A device for detecting chemiluminescence from a sample. The device may include a stage for supporting a sample and one or more of the following elements: (1) an optics head, (2) an optical relay structure for transmitting chemiluminescence from the sample to a detector, (3) a drive mechanism, (4) a sensor for detecting proximity of the optical relay structure to the sample, (5) a mask structure for selecting an effective diameter of the optical relay structure, and (6) a baffle for blocking extraneous light from entering the optical relay structure.
    Type: Grant
    Filed: September 2, 1998
    Date of Patent: February 13, 2001
    Assignee: LJL BioSystems, Inc.
    Inventors: Michael T. Taylor, Amer El-Hage, Glenn R. Edwards, Douglas N. Modlin
  • Patent number: 6097025
    Abstract: A high-throughput light detection instrument and method are described. In some embodiments, switch mechanisms and optical relay structures permit different light sources and/or detectors to be selected for different applications. In other embodiments, switch mechanisms and optical paths permit top/bottom illumination and/or top/bottom detection, or combinations thereof.
    Type: Grant
    Filed: September 24, 1998
    Date of Patent: August 1, 2000
    Assignee: LJL BioSystems, Inc.
    Inventors: Douglas N. Modlin, Glenn R. Edwards, Michael T. Taylor, Samuel A. Marquiss, Amer El-Hage, Craig S. Barker, Lorne B. Bechtel, Rick V. Stellmacher, Philip A. Granieri, Jr., Robert M. Lembi, Sr.
  • Patent number: 6071748
    Abstract: A high-throughput light detection instrument and method are described. Confocal optics structure enables exclusive light detection from a sensed volume in a composition.
    Type: Grant
    Filed: April 17, 1998
    Date of Patent: June 6, 2000
    Assignee: LJL BioSystems, Inc.
    Inventors: Douglas N. Modlin, Glenn R. Edwards, Michael T. Taylor, Samuel A. Marquiss
  • Patent number: 5509576
    Abstract: An autoinflator for automatically actuating a gas cartridge upon sensing of water. The autoinflator includes a fusible link actuator assembly positioned within a longitudinal bore. The fusible link assembly includes an actuator housing with a blind link hole, an actuator cap, and a pair of retaining balls protruding from the sides of said actuator housing which engage into a corresponding slot in the longitudinal bore to retain the actuator housing in a cocked position. A slidable link, positioned within the blind link hole, includes an annular groove positioned about its circumference at a rearward portion thereof and a taper positioned at a forward position thereof. A fusible link interconnects the actuator cap and the slidable link for retaining the slidable link rearwardly in a cocked position within the blind link hole.
    Type: Grant
    Filed: June 14, 1993
    Date of Patent: April 23, 1996
    Assignee: Halkey-Roberts Corporation
    Inventors: Jacek M. Weinheimer, Michael T. Taylor, Richard A. Boe
  • Patent number: 5400922
    Abstract: An electric autoinflator for inflating inflatable devices such as personal flotation devices, life rafts, buoys and emergency signalling equipment. The electric autoinflator comprises an actuator assembly including a fusible link. A water-sensing electrical circuit and battery supplies electrical current to the fusible link actuator assembly upon immersion in water for a predetermined period of time. Upon fusing of the link, the actuator assembly forcibly causes a firing pin of the inflator to pierce the frangible seal of a compressed gas cartridge. The escaping gas then inflates the inflatable device.
    Type: Grant
    Filed: July 14, 1992
    Date of Patent: March 28, 1995
    Assignee: Halkey-Roberts Corporation
    Inventors: Jacek M. Weinheimer, Michael T. Taylor, Richard A. Boe
  • Patent number: 5349984
    Abstract: A check valve having a presettable cracking pressure. The check valve employs a spring-loaded valve element in which the compression spring and valve element are held into position in the valve body by means of an apertured plug.
    Type: Grant
    Filed: January 25, 1993
    Date of Patent: September 27, 1994
    Assignee: Halkey-Roberts Corporation
    Inventors: Jacek M. Weinheimer, Michael T. Taylor, Terrence C. Allen