Patents by Inventor Michael Tangrea

Michael Tangrea has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20060172278
    Abstract: A device for performing target activated transfer that includes a mounting surface for mounting a tissue sample; and a light source positioned to substantially uniformly irradiate both stained and unstained regions of the tissue sample with light energy that activates the reagent to selectively adhere the stained regions to a transfer surface. Also described is an automated system for transferring tissue from a tissue sample to a transfer substrate. The system includes means for holding a tissue section that includes targets specifically stained with an absorptive stain thereby resulting in a stained tissue surface, and a flexible transfer film that includes a lower thermoplastic layer in sufficient thermal contact with the stained tissue surface; an irradiating assembly configured to provide a predetermined uniform light dose to the entire tissue section; and means for applying a constant pressure to the transfer film during irradiation.
    Type: Application
    Filed: August 12, 2005
    Publication date: August 3, 2006
    Inventors: Robert Bonner, Thomas Pohida, Michael Emmert-Buck, Michael Tangrea, Rodrigo Chuaqui
  • Publication number: 20060147926
    Abstract: This invention relates to methods and apparati for performing multiple simultaneous manipulations of biomolecules in a two-dimensional array, such as a gel, membrane, tissue biopsy, etc. Such manipulations particularly include assays and nucleic acid amplification protocols.
    Type: Application
    Filed: November 20, 2003
    Publication date: July 6, 2006
    Inventors: Michael Emmert-Buck, Rodrigo Chuaqui, Michael Tangrea
  • Publication number: 20060134692
    Abstract: A method of removing a target from a biological sample which involves placing a transfer surface in contact with the biological sample, and then focally altering the transfer surface to allow selective separation of the target from the biological sample. In disclosed embodiments, the target is a cell or cellular component of a tissue section and the transfer surface is a film that can be focally altered to adhere the target to the transfer surface. Subsequent separation of the film from the tissue section selectively removes the adhered target from the tissue section. The transfer surface is activated from within the target to adhere the target to the transfer surface, for example by heating the target to adhere it to a thermoplastic transfer surface. Such in situ activation can be achieved by exposing the biological sample to an immunoreagent that specifically binds to the target (or a component of the target).
    Type: Application
    Filed: July 23, 2003
    Publication date: June 22, 2006
    Inventors: Michael Emmert-Buck, Michael Tangrea, Robert Bonner, Rodrigo Chuaqui