Patents by Inventor Michael Teifel

Michael Teifel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • CONJUGATES OF DISORAZOLES AND THEIR DERIVATIVES WITH CELL-BINDING MOLECULES, NOVEL DISORAZOLE DERIVATIVES, PROCESSES OF MANUFACTURING AND USES THEREOF
    Publication number: 20100317580
    Abstract: The present invention provides conjugates of disorazoles and their derivatives with cell-binding molecules, such as peptides, proteins, hormones, blood proteins and antibodies. The present invention further provides novel disorazole derivatives and processes of manufacturing such conjugates and disorazole derivatives. These compounds can be used as medicaments for the treatment of physiological and/or pathophysiological conditions in mammals, in particular for the treatment of various tumors.
    Type: Application
    Filed: March 19, 2010
    Publication date: December 16, 2010
    Applicant: AETERNA ZENTARIS GmbH
    Inventors: Eckhard GUENTHER, Olaf Schaefer, Michael Teifel, Klaus Paulini
  • Method of producing a cationic liposomal preparation comprising a lipophilic compound
    Patent number: 7794747
    Abstract: A method for producing a cationic liposomal preparation comprising a lipophilic active compound with physical and chemical stability during manufacturing, storing and reconstituting, and further a cationic liposomal preparation obtainable by this method as well as specific cationic liposomal preparations as well as pharmaceutical compositions are disclosed.
    Type: Grant
    Filed: December 22, 2004
    Date of Patent: September 14, 2010
    Assignee: Medigene Oncology GmbH
    Inventors: Carsten Mundus, Christian Welz, Oliver Schramel, Heinrich Haas, Thomas Fichert, Brita Schulze, Toralf Peymann, Uwe Michaelis, Michael Teifel, Friedrich Gruber, Gerhard Winter
  • Novel method of stabilizing diagnostic and therapeutic compounds in a cationic carrier system
    Publication number: 20100178243
    Abstract: The present invention relates to a method of stabilizing a low molecular weight compound in a cationic liposome, wherein said compound has a low solubility in a lipid membrane and/or a low permeability across a lipid membrane. Preferrably, the compound is modified in order to increase lipid membrane solubility and/or lipid membrane permeability. After delivery of the cationic liposome to a target site, particularly a target site in an organism, the modification is reversed and the low molecular weight compound may enact its desired activity.
    Type: Application
    Filed: December 22, 2009
    Publication date: July 15, 2010
    Applicant: MediGene AG
    Inventors: Heinrich Haas, Thomas Fichert, Brita Schulze, Toralf Peymann, Uwe Michaelis, Michael Teifel
  • Conjugates of disorazoles and their derivatives with cell-binding molecules, novel disorazole derivatives, processes of manufacturing and uses thereof
    Patent number: 7741277
    Abstract: The present invention provides conjugates of disorazoles and their derivatives with cell-binding molecules, such as peptides, proteins, hormones, blood proteins and antibodies. The present invention further provides novel disorazole derivatives and processes of manufacturing such conjugates and disorazole derivatives. These compounds can be used as medicaments for the treatment of physiological and/or pathophysiological conditions in mammals, in particular for the treatment of various tumors.
    Type: Grant
    Filed: September 6, 2007
    Date of Patent: June 22, 2010
    Assignee: Aeterna Zentaris GmbH
    Inventors: Eckhard Guenther, Olaf Schaefer, Michael Teifel, Klaus Paulini
  • NOVEL TETRAHYDROCARBAZOLE DERIVATIVES AS LIGANDS OF G-PROTEIN COUPLED RECEPTORS
    Publication number: 20090170783
    Abstract: The present invention provides novel tetrahydrocarbazole compounds according to formula (I) as ligands of G-protein coupled receptors (GPCR) which are useful in the treatment and/or prophylaxis of physiological and/or pathological conditions in mammals mediated by GPCR or of physiological and/or pathological conditions which can be treated by modulation of these receptors.
    Type: Application
    Filed: April 25, 2008
    Publication date: July 2, 2009
    Applicant: AETERNA ZENTARIS GmbH
    Inventors: Tilmann Schuster, Klaus Paulini, Peter Schmidt, Silke Baasner, Emmanuel Polymeropoulos, Eckhard Guenther, Michael Teifel
  • CONJUGATES OF DISORAZOLES AND THEIR DERIVATIVES WITH CELL-BINDING MOLECULES, NOVEL DISORAZOLE DERIVATIVES, PROCESSES OF MANUFACTURING AND USES THEREOF
    Publication number: 20080090758
    Abstract: The present invention provides conjugates of disorazoles and their derivatives with cell-binding molecules, such as peptides, proteins, hormones, blood proteins and antibodies. The present invention further provides novel disorazole derivatives and processes of manufacturing such conjugates and disorazole derivatives. These compounds can be used as medicaments for the treatment of physiological and/or pathophysiological conditions in mammals, in particular for the treatment of various tumors.
    Type: Application
    Filed: September 6, 2007
    Publication date: April 17, 2008
    Applicant: AETERNA ZENTARIS GmbH
    Inventors: Eckhard Guenther, Olaf Schaefer, Michael Teifel, Klaus Paulini
  • Method of Administering Cationic Liposomes Comprising an Active Drug
    Publication number: 20080063699
    Abstract: The present invention relates to the use of pharmaceutical preparations comprising paclitaxel for administration to a human patient in need thereof.
    Type: Application
    Filed: October 15, 2004
    Publication date: March 13, 2008
    Inventors: Michael Teifel, Uwe Michaelis, Birgitta Sauer, Kerstin Bartelheim, Christoph Brunner, Kurt Naujoks
  • Camptothecin-carboxylate formulations
    Publication number: 20060128736
    Abstract: The present invention relates to compositions, particularly colloidal nanoaggregates comprising the carboxylate form of a campothecin drug or a derivative thereof associated with at least one organic cationic molecule, which has a positive net charge. The composition or nanoaggregate may be present as an emulsion, droplet, mincelle, liposome, nanoparticle or nanocapsule.
    Type: Application
    Filed: June 26, 2003
    Publication date: June 15, 2006
    Inventors: Heinrich Haas, Brita Schulze, Uwe Michaelis, Michael Teifel, Birgitta Sauer, Thomas Fichert
  • Method of producing a cationic liposomal preparation comprising a lipophilic compound
    Publication number: 20050202076
    Abstract: A method for producing a cationic liposomal preparation comprising a lipophilic active compound with physical and chemical stability during manufacturing, storing and reconstituting, and further a cationic liposomal preparation obtainable by this method as well as specific cationic liposomal preparations as well as pharmaceutical compositions are disclosed.
    Type: Application
    Filed: December 22, 2004
    Publication date: September 15, 2005
    Inventors: Carsten Mundus, Christain Welz, Oliver Schramel, Heinrich Haas, Thomas Fichert, Brita Schulze, Toralf Peymann, Uwe Michaelis, Michael Teifel, Friedrich Gruber, Gerhard Winter
  • Novel method of stabilizing diagnostic and therapeutic compounds in a cationic carrier system
    Publication number: 20050181038
    Abstract: The present invention relates to a method of stabilizing a low molecular weight compound in a cationic liposome, wherein said compound has a low solubility in a lipid membrane and/or a low permeability across a lipid membrane. Preferrably, the compound is modified in order to increase lipid membrane solubility and/or lipid membrane permeability. After delivery of the cationic liposome to a target site, particularly a target site in an organism, the modification is reversed and the low molecular weight compound may enact its desired activity.
    Type: Application
    Filed: December 22, 2004
    Publication date: August 18, 2005
    Inventors: Heinrich Haas, Thomas Fichert, Brita Schulze, Toralf Peymann, Uwe Michaelis, Michael Teifel
  • Cationic diagnostic, imaging and therapeutic agents associated with activated vascular sites
    Publication number: 20020034537
    Abstract: Methods and associated compositions are described for enhancing the selective delivery of therapeutic, diagnostic and imaging agents to activated vascular sites.
    Type: Application
    Filed: May 3, 2001
    Publication date: March 21, 2002
    Inventors: Brita Schulze, Birgitta Sauer, Marc Dellian, Uwe Michaelis, Michael Teifel, Kurt W. Naujoks, Claudia Biro