Abstract: An ice making assembly includes an ice mold and a pump assembly for urging an ice-building spray into the ice mold to form an ice billet. A controller operates the pump assembly to provide the ice-building spray at a first flow rate until the ice billet reaches a predetermined thickness and then operates the pump assembly to provide the ice-building spray at a second flow rate that is less than the first flow rate.

Abstract: A three-dimensional printed swab may include a shaft defining a longitudinal axis of the swab, and a tip portion integrally formed with the shaft. The tip portion may include a body extending outward from the shaft and positioned coaxially with the longitudinal axis, and a plurality of protrusions each extending outward from the body and transverse to the longitudinal axis. Alternatively, the tip portion may include a body extending outward from the shaft and positioned coaxially with the longitudinal axis, and a plurality of recesses each defined in the body and extending inward toward the longitudinal axis. As another alternative, the tip portion may include a body extending outward from the shaft and positioned coaxially with the longitudinal axis, and a series of annular ribs each extending outward from the body and positioned coaxially with the longitudinal axis.

Abstract: A three-dimensional printed swab may include a shaft defining a longitudinal axis of the swab, and a tip portion integrally formed with the shaft. The tip portion may include a plurality of protrusions each extending outward from the shaft and transverse to the longitudinal axis. A method for fabricating a three-dimensional printed swab may include receiving a digital three-dimensional model corresponding to the swab, and integrally forming, via three-dimensional printing and based at least in part on the digital three-dimensional model, a shaft and a tip portion of the swab. The shaft may define a longitudinal axis of the swab. The tip portion may include a plurality of protrusions each extending outward from the shaft and transverse to the longitudinal axis.

Abstract: Described herein are peptibodies that can contain a TertiapinQ peptide, formulations thereof, and uses thereof. In some embodiments, the peptibody can include a first monomer and a second monomer, wherein each monomer can include an Fc polypeptide, a first TertiapinQ peptide, wherein the N-terminus of the first TertiapinQ peptide can be linked to the C-terminus of the Fc polypeptide via a first linker, and wherein the first monomer and the second monomer can be attached via a disulfide bridge between the Fc polypeptide of the first monomer and the Fc polypeptide of the second monomer. The compositions and formulations thereof can be used to treat atrial fibrillation.

Abstract: Described herein are peptibodies that can contain a TertiapinQ peptide, formulations thereof, and uses thereof. In some embodiments, the peptibody can include a first monomer and a second monomer, wherein each monomer can include an Fc polypeptide, a first TertiapinQ peptide, wherein the N-terminus of the first TertiapinQ peptide can be linked to the C-terminus of the Fc polypeptide via a first linker, and wherein the first monomer and the second monomer can be attached via a disulfide bridge between the Fc polypeptide of the first monomer and the Fc polypeptide of the second monomer. The compositions and formulations thereof can be used to treat atrial fibrillation.

Abstract: Attenuated respiratory syncytial virus (RSV) and vaccine compositions thereof are produced by introducing specific mutations associated with attenuating phenotypes into wild-type or RSV which is incompletely attenuated by cold-passage or introduction of mutations which produce virus having a temperature sensitive (ts) or cold adapted (ca) phenotype. Alternatively, recombinant RSV and vaccine compositions thereof incorporate attenuating and other mutations specifying desired structural and or phenotypic characteristics in an infectious RSV. Recombinant RSV incorporate desired mutations specified by insertion, deletion, substitution or rearrangement of a selected nucleotide sequence, gene, or gene segment in an infectious RSV clone. The immune system of an individual is stimulated to induce protection against natural RSV infection, or multivalently against infection by RSV and another pathogen, such as PIV, by administration of attenuated, biologically derived or recombinant RSV.

Abstract: A system and method for checking and validating Extensible Markup Language (XML) data before sending a XML document to a receiving partner. The XML data tags used by Partner A may be incomprehensible to Partner B. A database is used to reformat the XML document based on the compatibility requirements of the receiving party.

Abstract: A system and method for conversion of a XML document to a HTML document such that the HTML document is traced back to the original XML document. A recipient views the converted XML document as a HTML document and then makes changes to the HTML document. The changes made by the recipient are incorporated into the HTML document as it is traced, i.e., converted, back into the original XML document.