Patents by Inventor Michael Thomas Brandl

Michael Thomas Brandl has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • CRYSTALLINE FORMS OF N-(4-(1-(2,6-DIFLUOROBENZYL)-5-((DIMETHYLAMINO)METHYL)-3-(6-METHOXY-3-PYRIDAZINYL)-2,4-DIOXO-1,2,3,4-TETRAHYDROTHIENO[2,3-D]PYRIMIDIN-6-YL)PHENYL)-N'-METHOXYUREA
    Publication number: 20220396582
    Abstract: This disclosure relates to novel crystalline forms of N-(4-(1-(2,6-difluorobenzyl)-5-((dimethylamino)methyl)-3-(6-methoxy-3-pyridazinyl)-2,4-dioxo-1,2,3,4-tetrahydrothieno[2,3-d]pyrimidin-6-yl)phenyl)-N?-methoxyurea. It also relates to methods of making the disclosed crystalline forms, pharmaceutical compositions and kits comprising them, and methods of treatment and uses comprising their administration.
    Type: Application
    Filed: April 8, 2022
    Publication date: December 15, 2022
    Inventors: Michael Thomas BRANDL, Patricia ANDRES, Petinka I. VLAHOVA, Tsuyoshi Sasaki
  • Pharmaceutical composition and process
    Patent number: 7893037
    Abstract: The present invention relates to a method of forming granules of (2R,3S,4R,5R)-5-(4-amino-2-oxo-2H-pyrimidin-1-yl)-2-azido-3,4-bis-iso-butyryloxy-tetrahydro-furan-2-ylmethyl isobutyrate; hydrochloride salt (I), comprising mixing I, with a granulating amount of a granulating liquid, and a polyethylene glycol (PEG)/polypropylene glycol (PPG) block copolymer as a binder and solubility enhancer to form wet granules which are then dried to remove the granulating liquid.
    Type: Grant
    Filed: March 28, 2008
    Date of Patent: February 22, 2011
    Assignee: Roche Palo Alto LLC
    Inventors: Kondamraj Birudaraj, Michael Thomas Brandl, Shridhar Hegde, Felix Sana, Dimitrios Stefanidis
  • Pharmaceutical composition and process
    Patent number: 7795237
    Abstract: The present invention relates to a pharmaceutical composition comprising a solid suspension prepared by hot melt extrusion of isobutyric acid (2R,3S,4R,5R)-5-(4-amino-2-oxo-2H-pyrimidin-1-yl)-2-azido-3,4-bis-iso-butyryloxy-tetrahydro-furan-2-ylmethyl ester; hydrochloride salt (I) and a polyethylene glycol (PEG)/polypropylene glycol (PPG) block copolymer.
    Type: Grant
    Filed: December 13, 2006
    Date of Patent: September 14, 2010
    Inventors: Hashim A. Ahmed, Thomas Vernon Alfredson, Kondamraj Birudaraj, Michael Thomas Brandl, Wantanee Phuapradit, Navnit Hargovindas Shah, Dimitrios Stefanidis
  • Pharmaceutical composition and process
    Publication number: 20080260826
    Abstract: The present invention relates to a method of forming granules of (2R,3S,4R,5R)-5-(4-amino-2-oxo-2H-pyrimidin-1-yl)-2-azido-3,4-bis-iso-butyryloxy-tetrahydro-furan-2-ylmethyl isobutyrate; hydrochloride salt (I), comprising mixing I, with a granulating amount of a granulating liquid, and a polyethylene glycol (PEG)/polypropylene glycol (PPG) block copolymer as a binder and solubility enhancer to form wet granules which are then dried to remove the granulating liquid.
    Type: Application
    Filed: March 28, 2008
    Publication date: October 23, 2008
    Inventors: Kondamraj Birudaraj, Michael Thomas Brandl, Shridhar Hegde, Felix Sana, Dimitrios Stefanidis