Patents by Inventor Michael Thomas CORBETT

Michael Thomas CORBETT has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • SYNTHESIS OF KRAS G12C INHIBITOR COMPOUND
    Publication number: 20250206736
    Abstract: The present disclosure relates to an improved, efficient, scalable process to prepare intermediate compounds, such as 2-isopropyl-4-methylpyridin-3-amine, useful for the synthesis of compounds, such as Compound 9, for the treatment of KRAS G12C mutated cancers.
    Type: Application
    Filed: December 19, 2024
    Publication date: June 26, 2025
    Applicant: AMGEN INC.
    Inventors: Michael Thomas CORBETT, Sebastien CAILLE
  • SYNTHESIS OF A KIF18A INHIBITOR
    Publication number: 20250129050
    Abstract: The present invention relates to improved preparation of a KIF18A inhibitor having the chemical structure Compound (1), or a salt thereof Compound (la); wherein HA is as defined herein; and key intermediates thereof, i.e., Compound (2a), Compound (3a), Compound (5) or a salt thereof, and Compound (6a) or a hydrate thereof, of the formulae: Compound (2a); Compound (3a); Compound (5) or a salt thereof; and Compound (6a) or a hydrate thereof, preferably Compound (6a-1). The present invention further relates to solid form of Compound (6a), preferably the crystalline hydrate form of Compound (6a-1).
    Type: Application
    Filed: January 26, 2023
    Publication date: April 24, 2025
    Applicant: Amgen Inc.
    Inventors: Sebastien CAILLE, Daniel Gerard GREENE, Michael Thomas CORBETT, Carolyn WEI
  • IMPROVED SYNTHESIS OF KRAS G12C INHIBITOR COMPOUND
    Publication number: 20230192682
    Abstract: The present disclosure relates to an improved, efficient, scalable process to prepare intermediate compounds, such as 2-isopropyl-4-methylpyridin-3-amine, useful for the synthesis of compounds, such as Compound 9, for the treatment of KRAS G12C mutated cancers.
    Type: Application
    Filed: November 13, 2020
    Publication date: June 22, 2023
    Inventors: Michael Thomas CORBETT, Sebastien CAILLE