Abstract: The present invention relates to compounds which modulate (e.g., inhibit) the activity of beta-hydrolase (e.g., ASPH), including novel 2-aryl-5-amino-3(2H)-furanone and 2-heteroaryl-5-amino-3(2H)-furanone compounds, pharmaceutical compositions thereof, methods for their synthesis, and methods of using these compounds to modulate the activity of ASPH in an a cell-free sample, a cell-based assay, and in a subject. Other aspects of the invention relate to use of the compounds disclosed herein to ameliorate or treat cell proliferation disorders.

Abstract: A method for the concurrent treatment of obstructive sleep apnea and hypertension in a patient, the method comprises: a) providing a flow of treatment to an airway of the patient in accordance with an initial set of flow parameters; b) determining that the patient has achieved stable breathing while receiving the provided flow of treatment gas in accordance with the initial set of parameters; c) increasing the flow parameters; d) providing the flow of treatment gas to the airway of the patient in accordance with the increased flow parameters until it is determined that a predetermined period of time has elapsed; e) further increasing the flow parameters; and f) providing the flow of treatment gas to the airway of the patient in accordance with the further increased flow parameters for a predetermined time.

Abstract: A hybrid-electric propulsion system includes a propulsor, a turbomachine, and an electrical system, the electrical system including an electric machine coupled to the turbomachine. A method for operating the propulsion system includes operating, by one or more computing devices, the turbomachine such that the turbomachine rotates the propulsor; receiving, by the one or more computing devices, a command to accelerate the turbomachine while operating the turbomachine; and providing, by the one or more computing devices, electrical power to the electric machine to add power to the turbomachine, the propulsor, or both in response to the received command to accelerate the turbomachine.

Abstract: A hybrid-electric propulsion system includes a turbomachine, a propulsor coupled to the turbomachine, and an electrical system, the electrical system including an electric machine coupled to the turbomachine. A method for operating a hybrid-electric propulsion system includes operating, by one or more computing devices, the turbomachine in an idle operating condition; receiving, by the one or more computing devices, a command to accelerate the turbomachine while operating the turbomachine in the idle operating condition; and providing, by the one or more computing devices, electrical power to the electric machine to add power to the turbomachine and increase an acceleration of the turbomachine in response to the received command to accelerate the turbomachine.

Abstract: Systems and methods for secure, policy-based, access control and management of mobile computing devices, including policy decision enforcement mechanisms, device and private network presence testing, aspects of file system controls, policy set sanity checking algorithms, performance optimizations.

Abstract: A hybrid-electric propulsion system includes a propulsor, a turbomachine, and an electrical system. The electrical system includes a first electric machine coupled to the turbomachine and an electric energy storage unit. A method for operating the propulsion system includes operating the hybrid electric propulsion system in a flight operation mode. The method also includes operating the hybrid electric propulsion system in a maintenance operation mode, wherein operating the hybrid electric propulsion system in the maintenance operation mode includes providing electrical power from an electrical power source to the first electric machine such that the first electric machine rotates a compressor and a turbine of the turbomachine during a borescope inspection of the turbomachine.

Abstract: A hybrid-electric propulsion system includes a turbomachine and an electric machine coupled to the turbomachine. A method for operating the hybrid-electric propulsion system includes receiving information indicative of an operability parameter of the turbomachine; determining the turbomachine is operating within a predetermined operability range based at least in part of the received information indicative of the operability parameter of the turbomachine; and operating the hybrid electric propulsion system in an electric generation mode to generate electric power with the electric machine in response to determining the turbomachine is operating within the predetermined operability range.

Abstract: A hybrid-electric propulsion system includes an electric machine coupled to a rotating system of the turbomachine and an electric energy storage unit, the electric machine electrically coupled to an electric power source. A method for operating the turbomachine of a hybrid-electric propulsion system includes providing electrical power from the electric machine to the electric energy storage unit during a flight operation mode of the turbomachine, the turbomachine rotating the electric machine to generate electrical power during the flight operating mode; determining the turbomachine is in a post flight operation mode or in a pre-flight operation mode; and providing electrical power from the electric power source to the electric machine such that the electric machine rotates the rotating system of the turbomachine to prevent or correct a bowed rotor condition.

Abstract: Systems and methods for estimating engine and electrical machine health are provided. The systems and methods therefore include features that provide for improved health estimates of one or more engines and/or electrical machines of one or more engines having an electrical machine embedded therein or coupled thereto. In particular, the systems and methods therefore include features for utilizing sensed or measured operating parameters of the electrical machines and/or operating parameters of the prime mover to estimate the health of the prime mover and/or the electrical machines embedded therein or coupled thereto.

Abstract: Techniques are disclosed for implementing a unified partitioning scheme within distributed database systems to allow a table to be horizontally partitioned and those partitions stored on and serviced by a storage group. A storage group is a subset of storage manager (SM) nodes, and each SM node is configured to persist database data in durable storage. The distributed database system assigns each storage group to a subset of SM nodes. The distributed database system can address each storage group using a symbolic mapping that allows transactions to identify a particular storage group, and to direct read and write operations to a subset of SM nodes servicing that storage group. An administrator can update this mapping on-the-fly to cause the distributed database system to dynamically adjust an implemented partitioning scheme without necessarily interrupting on-going database operations.

Abstract: Variety of approaches to provide an event based activity service are described. A communication service initiates operations) to provide the event based activity service upon analyzing at least a portion of a conversation. An activity associated with the conversation is inferred froth the analyzed portion. Next, an item associated with the activity is created. A creation notification associated with the item is inserted into the conversation.

Abstract: A computer-implemented method of assessing a health of a gas turbine engine of a hybrid-electric propulsion system for an aircraft includes receiving, by one or more computing devices, data indicative of an amount of electrical power provided to, or extracted from, an electric machine. The method also includes receiving, by the one or more computing devices, data indicative of an operating parameter of the hybrid-electric propulsion system. The method also includes assessing, by the one or more computing devices, a health of the gas turbine engine based at least in part on the received data indicative of the amount of electrical power provided to, or extracted from, the electric machine and the received data indicative of the operating parameter of the hybrid electric propulsion system. The method also includes providing, by the one or more computing devices, information to a user indicative of the health of the gas turbine engine.

Abstract: A hybrid-electric propulsion system for an aircraft includes a propulsor and a turbomachine. The turbomachine includes a high pressure turbine drivingly coupled to a high pressure compressor through a high pressure spool. The hybrid electric propulsion system further includes an electrical system including a first electric machine, a second electric machine, and an electric energy storage unit electrically connectable to the first and second electric machines. The first electric machine is coupled to the high pressure spool of the turbomachine and the second electric machine is coupled to the propulsor for driving the propulsor to provide a propulsive benefit for the aircraft. The hybrid electric propulsion system also includes a controller configured to provide electrical power from an electric power source to the first electric machine to drive the first electric machine to start, or assist with starting, the turbomachine.

Abstract: A hybrid-electric propulsion system for an aircraft includes a turbomachine, the turbomachine including a first spool and a second spool. A method for operating the hybrid electric propulsion system includes operating, by one or more computing devices, the turbomachine such that the first spool mechanically drives a prime propulsor of the hybrid-electric propulsion system; and modifying, by the one or more computing devices, a speed relationship parameter defined between the first spool and second spool by providing electrical power to, or drawing electrical power from, an electric machine mechanically coupled to the first spool, the second spool, or both.

Abstract: Described herein are oligosaccharyl transferases for use in N-glycosylating proteins of interest in vitro and in host cells. Methods for using such oligosaccharyl transferases, nucleic acids encoding such oligosaccharyl transferases, and host cells comprising such oligosaccharyl transferases are also provided herein. Glycoconjugates generated by using such oligosaccharyl transferases are also provided herein.

Abstract: A pair of spotter arms for use with a weight bench comprising a right and a left spotter arm having respective right and left spotter arm benches, each with a safety bar, a cross bar and a curl support bar, the safety bars, cross bars and a curl support bars each having a top surface forming a common plane, the spotter arms being coupled to a weight bench via two vertical supports captured by clamps extending from the curl support bars, and having six adjustable length legs for adjusting the height of the plane above the chest of a weight lifter on the weight bench, the spotter arm safety bars being positioned to interfere with an inadvertent and dangerous decent of a barbell bar, the safety bars being positioned to stop the decent of the barbell bar.

Abstract: Technologies are described for an audio jack housing configured to concentrically align with an opening in a chassis of a computing device and to accept a plug associated with external audio components. When the housing is aligned with the opening, a snout of the audio jack housing abuts an interior surface of the opening and does not protrude into the opening. The chassis where the opening is located may be constructed from a plastic material to reduce a risk of shorting-out when a metal plug is inserted into the housing. The chassis may include alignment features to concentrically align the audio jack housing with the opening during assembly, such that interior edges of the opening and interior edges of the snout are flush creating a smooth interior entry into the audio jack housing through the opening and the snout.

Abstract: The present disclosure generally relates to a combined multicoupler for connecting a tool to a top drive. The combined multicoupler includes a load frame comprising a frame body having a load shoulder, and a side door coupled to the frame body. The side door opens from the frame body to allow a tool sliding horizontally into the load shoulder, and the side door closes to lock the tool in the load frame. The combined multicoupler further comprises a drive stem movably coupled to the load frame, wherein the drive stem moves vertically to connect and disconnect with the tool in the load frame.

Abstract: An optical assembly for a point action camera or other compact digital camera having a wide field of view, includes multiple lens elements, including at least one lens element that has an aspheric lens surface. The optical assembly is configured to provide a field of view in excess of 120 degrees. The optical assembly includes a ratio of a diameter of a first lens element at the object end of the optical assembly to an image diagonal is less than approximately 3.

Abstract: An optical assembly for a wide field of view digital camera includes, from object end to image end, first and second optical groups separated by an aperture stop. The optical assembly is configured to provide images with TV distortion that is less than 16. The first optical group includes two or more lens elements, including a first lens element having a largest diameter among the multiple lens elements to collect light at said wide field of view. The second optical group includes a doublet, which is configured to compensate for oblique aberrational error, and an aspheric lens element, which is configured to compensate for astigmatism error.