Patents by Inventor Michael Tolar Martin

Michael Tolar Martin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • DERIVATIVES OF BETULIN
    Publication number: 20170348324
    Abstract: The present invention relates to compounds characterized by having a structure according to the following Formula I: , or a pharmaceutically acceptable salt thereof. Compounds of the present invention are useful for the treatment or prevention of HIV.
    Type: Application
    Filed: August 24, 2017
    Publication date: December 7, 2017
    Inventors: Mark Andrew HATCHER, Brian Alvin Johns, Michael Tolar Martin, Elie Amine Tabet, Jun Tang
  • DERIVATIVES OF BETULIN
    Publication number: 20160120878
    Abstract: The present invention relates to compounds characterized by having a structure according to the following formula I: or a pharmaceutically acceptable salt thereof. Compounds of the present invention are useful for the treatment or prevention of HIV.
    Type: Application
    Filed: December 23, 2015
    Publication date: May 5, 2016
    Inventors: Mark Andrew HATCHER, Brian Alvin JOHNS, Michael Tolar MARTIN, Elie Amine TABET, Jun TANG
  • Derivatives of Betulin
    Publication number: 20150218142
    Abstract: The present invention relates to compounds characterized by having a structure according to the following Formula I: or a pharmaceutically acceptable salt thereof. Compounds of the present invention are useful for the treatment or prevention of HIV.
    Type: Application
    Filed: December 14, 2012
    Publication date: August 6, 2015
    Applicant: GlaxoSmithKline LLC
    Inventors: Mark Andrew Hatcher, Brian Alvin Johns, Michael Tolar Martin, Elie Amine Tabet, Jun Tang
  • Preparation of a quinolinyloxydiphenylcyclopropanedicarboxamide
    Patent number: 8314232
    Abstract: The present invention relates to a process of preparing a compound of the following formula III: wherein R1-R4 are as defined herein. The present invention also relates to the preparation of intermediates used to prepare the compound of formula III.
    Type: Grant
    Filed: September 25, 2009
    Date of Patent: November 20, 2012
    Assignee: GlaxoSmithKline LLC
    Inventors: Nicole Marie Deschamps, Michael Tolar Martin, Michael John Monteith, Xiaoming Zhou
  • CHEMICAL PROCESS
    Publication number: 20110224413
    Abstract: Disclosed herein are processes for preparing glucopyranosyloxypyrazole derivatives and pyrazole intermediates of the same. In particular, the present invention relates to glucopyranosyloxypyrazole derivatives having SGLT2 inhibitory activity and processes and intermediates for preparing the same.
    Type: Application
    Filed: November 19, 2009
    Publication date: September 15, 2011
    Inventors: Michael Tolar Martin, Michael S. McClure, Vassil Elitzin
  • GLYCOGEN PHOSPHORYLASE INHIBITOR COMPOUND AND PHARMACEUTICAL COMPOSITION THEREOF
    Publication number: 20100305207
    Abstract: This invention relates to a novel compound which is a glycogen phosphorylase inhibitor and its use in the treatment of diabetes and other conditions associated therewith. The invention further relates to a pharmaceutical composition containing the compound and to processes for preparing the compound and pharmaceutical composition.
    Type: Application
    Filed: September 25, 2008
    Publication date: December 2, 2010
    Inventors: Pierette Banker, Eric Eugene Boros, Scott Howard Dickerson, Istvan Kaldor, Cecilia S. Koble, Michael Tolar Martin, Steven Meagher Sparks, Stephen Andrew Thomson
  • Preparation of a Quinolinyloxydiphenylcyclopropanedicarboxamide
    Publication number: 20100081805
    Abstract: The present invention relates to a process of preparing a compound of the following formula III: wherein R1-R4 are as defined herein.
    Type: Application
    Filed: September 25, 2009
    Publication date: April 1, 2010
    Inventors: Nicole Marie Deschamps, Michael Tolar Martin, Michael John Monteith, Xiaoming Zhou
  • Triphenylethylene compounds as selective estrogen receptor modulators
    Patent number: 7442833
    Abstract: Compounds of formula (I): with a variety of therapeutic uses, more particularly novel prodrugs that are particularly useful for delivering a parent compound for selective estrogen receptor modulation.
    Type: Grant
    Filed: October 4, 2004
    Date of Patent: October 28, 2008
    Assignee: SmithKline Beecham Corporation
    Inventors: John Fred Eaddy, III, Dennis Heyer, Amarjit Sab Randhawa, Vicente Samano, John Albert Ray, Subba Reddy Katamreddy, Michael Tolar Martin, Michael Scott McClure
  • Process for preparing reverse transcriptase inhibitors
    Patent number: 7378550
    Abstract: The present invention is directed to processes for the synthesis of intermediates useful in the preparation of non-nucleoside reverse transcriptase inhibitors.
    Type: Grant
    Filed: March 26, 2004
    Date of Patent: May 27, 2008
    Assignee: SmithKline Beecham Corporation
    Inventor: Michael Tolar Martin
  • Chloropyrimidine intermediates
    Patent number: 6870053
    Abstract: The present invention relates to certain novel pyrimidine intermediates and their salts, processes for their preparation and processes for their conversion to 9-substituted-2-aminopurines which are useful in medical therapy.
    Type: Grant
    Filed: June 27, 2002
    Date of Patent: March 22, 2005
    Assignee: SmithKline Beecham Corporation
    Inventors: Susan Mary Daluge, Michelle Joanne Fugett, Michael Tolar Martin
  • Methods of treating periodontal disease
    Patent number: 6770267
    Abstract: The present invention relates to methods of treating periodontal disease.
    Type: Grant
    Filed: March 26, 2002
    Date of Patent: August 3, 2004
    Assignee: SmithKline Beecham Corporation
    Inventors: Susan Mary Daluge, Cynthia Holder Jurgensen, Michael Tolar Martin, Martin Howard Osterhout
  • Methods of treating periodontal disease
    Publication number: 20040034020
    Abstract: The present invention relates to methods of treating periodontal disease.
    Type: Application
    Filed: February 3, 2003
    Publication date: February 19, 2004
    Inventors: Susan Mary Daluge, Cynthia Holder Jurgensen, Michael Tolar Martin, Martin Howard Osterhout
  • Chloropvrimidine intermediates
    Publication number: 20030187263
    Abstract: The present invention relates to certain novel pyrimidine intermediates and their salts, processes for their preparation and processes for their conversion to 9-substituted-2-aminopurines which are useful in medical therapy.
    Type: Application
    Filed: March 18, 2003
    Publication date: October 2, 2003
    Applicant: SmithKline Beecham Corporation
    Inventors: Susan Mary Daluge, Michelle Joanne Fugett, Michael Tolar Martin
  • Phenyl xanthine derivatives
    Patent number: 6608069
    Abstract: The present invention relates to novel compounds of formula (I): wherein Z represents a 5 or 6 membered cycloalkyl, aryl, substituted cycloalkyl, or substituted aryl, said cycloalkyl, aryl, substituted cycloalkyl or substituted aryl optionally containing one or more heteroatoms selected from 0, N or S; k represents 0 or 1; n represents an integer of 1 to 50; X represents —O—, —N(H)—, —N(C1-6alkyl)-, —N(C3-8cycloalkyl)-, —N(C1-8alkyl)(C3-8 cycloalkyl), —N[(CH2CH2O)m(C1-12 alkyl, aryl, or aralkyl)]-, —CH2O—, —CH2NH—, —CH2N(C1-6alkyl)-, —CH2N(C3-8cycloalkyl)-, or —C1-12alkyl-; Q represents (—CH2)p, (—CH═CH—)p, (—C≡C—)p, (—(O)p1CH2—)p or (—CH2(O)p1)p R6 and R7 independently represent O or S; and all other variables are as defined herein; processes for their preparation, pharmaceutical formulations containing them, and their use in me
    Type: Grant
    Filed: February 9, 2001
    Date of Patent: August 19, 2003
    Assignee: SmithKline Beecham Corporation
    Inventors: Susan Mary Daluge, Michael Tolar Martin, Martin Howard Osterhout
  • Chloropyrimidine intermediates
    Patent number: 6555687
    Abstract: The present invention relates to certain novel pyrimidine intermediates and their salts, processes for their preparation and processes for their conversion to 9-substituted-2-aminopurines which are useful in medical therapy.
    Type: Grant
    Filed: October 24, 1997
    Date of Patent: April 29, 2003
    Inventors: Susan Mary Daluge, Michael Tolar Martin
  • Chloropyrimidine intermediates
    Patent number: 6552193
    Abstract: The present invention is directed to a compound of formula (III) useful in the preparation of 9-substituted 2-aminopurines.
    Type: Grant
    Filed: October 15, 1999
    Date of Patent: April 22, 2003
    Assignee: SmithKline Beecham Corporation
    Inventors: Susan Mary Daluge, Michelle Joanne Fugett, Michael Tolar Martin
  • Methods of treating periodontal disease
    Publication number: 20030032804
    Abstract: The present invention relates to novel compounds of formula (I): processes for their preparation, pharmaceutical formulations containing them, and their use in medicine, particularly in the prophylaxis and treatment of inflammatory conditions, immune disorders, septic shock circulatory disorders, and gastrointestinal inflammation and disorders.
    Type: Application
    Filed: March 26, 2002
    Publication date: February 13, 2003
    Inventors: Susan Mary Daluge, Cynthia Holder Jurgensen, Michael Tolar Martin, Martin Howard Osterhout
  • Chloropvrimidine intermediates
    Publication number: 20020173649
    Abstract: The present invention relates to certain novel pyrimidine intermediates and their salts, processes for their preparation and processes for their conversion to 9-substituted-2-aminopurines which are useful in medical therapy.
    Type: Application
    Filed: June 27, 2002
    Publication date: November 21, 2002
    Inventors: Susan Mary Daluge, Michelle Joanne Fugett, Michael Tolar Martin
  • Chloropyrimidine intermediates
    Patent number: 6448403
    Abstract: A compound of formula (VI) A process for the preparation of a compound of formula (VI): comprising: reacting a compound of formula (III): with an amine of formula R3NH2.
    Type: Grant
    Filed: July 31, 1996
    Date of Patent: September 10, 2002
    Assignee: SmithKline Beecham Corporation
    Inventors: Susan Mary Daluge, Michael Tolar Martin
  • Chloropyrimidine intermediates and processes for their preparation
    Patent number: 6087501
    Abstract: A process for the preparation of a compound of formula (III) ##STR1## by hydrolyzing a compound of formula (I) or (II) ##STR2## wherein R.sup.1 and R.sup.2, which may be the same or different, are selected from C.sub.1-8 alkyl, C.sub.3-8 cycloalkyl, and optionally substituted aryl, in the presence of acid at a pH above 2.0.
    Type: Grant
    Filed: October 24, 1997
    Date of Patent: July 11, 2000
    Assignee: Glaxo Wellcome Inc.
    Inventors: Susan Mary Daluge, Michael Tolar Martin