Patents by Inventor Michael Tong
Michael Tong has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11970479Abstract: The present invention is directed to cinnolinyl and quinolinyl pyrazol-4-yl-pyridine compounds which are allosteric modulators of the M4 muscarinic acetylcholine receptor. The present invention is also directed to uses of the compounds described herein in the potential treatment or prevention of neurological and psychiatric disorders and diseases in which M4 muscarinic acetylcholine receptors are involved. The present invention is also directed to compositions comprising these compounds. The present invention is also directed to uses of these compositions in the potential prevention or treatment of such diseases in which M4 muscarinic acetylcholine receptors are involved.Type: GrantFiled: October 24, 2019Date of Patent: April 30, 2024Assignees: Merck Sharp & Dohme LLC, MSD R&D (China) Co. LTD.Inventors: John J. Acton, III, Melissa Egbertson, Xiaolei Gao, Scott T. Harrison, Timothy J. Henderson, Michael Man-Chu Lo, Robert D. Mazzola, Jr., Zhaoyang Meng, James Mulhearn, Vanessa L. Rada, Jeffrey W. Schubert, Oleg B. Selyutin, David M. Tellers, Ling Tong, Fengqi Zhang, Jianming Bao, Chunsing Li
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Patent number: 11939320Abstract: Provided herein are compounds, compositions, and methods useful for modulating the integrated stress response (ISR) and for treating related diseases; disorders and conditions.Type: GrantFiled: November 2, 2018Date of Patent: March 26, 2024Assignee: AbbVie Inc.Inventors: Jennifer M. Frost, Lei Shi, Yunsong Tong, Michael J. Dart, Kathleen J. Murauski
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Publication number: 20240083910Abstract: The present invention relates to novel Amido-Substituted Heterocycle Compounds of Formula (I): and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, and R5 are as defined herein. The present invention also relates to compositions comprising at least one Amido-Substituted Heterocycle Compounds for treating or preventing a herpesvirus infection in a patient.Type: ApplicationFiled: December 14, 2021Publication date: March 14, 2024Applicant: Merck Sharp & Dohme LLCInventors: Richard Thaddeus Berger, JR., Christopher Douglas Cox, Brendan M. Crowley, Marc Labroli, Michael Aaron Plotkin, Izzat Tiedje Raheem, Deyou Sha, Anthony W. Shaw, Jason W. Skudlarek, Ling Tong
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Publication number: 20240075026Abstract: The present invention features solid pharmaceutical compositions comprising Compound 1 and Compound 2. In one embodiment, the solid pharmaceutical composition includes (1) a first layer which comprises 100 mg Compound 1, as well as a pharmaceutically acceptable hydrophilic polymer and a pharmaceutically acceptable surfactant, all of which are formulated in amorphous solid dispersion; and (2) a second layer which comprises 40 mg Compound 2, as well as a pharmaceutically acceptable hydrophilic polymer and a pharmaceutically acceptable surfactant, all of which are formulated in amorphous solid dispersion.Type: ApplicationFiled: February 8, 2023Publication date: March 7, 2024Applicant: AbbVie Inc.Inventors: Nancy E. Sever, Ulrich Westedt, Ute Lander, Katrin Schneider, Benedikt Steitz, Thomas Mueller, Regina Reul, Constanze Obermiller, Adivaraha Jayasankar, Michael Simon, Yi Gao, Harald Hach, Samuel Kyeremateng, Katharina Asmus, Ping Tong, Donghua Zhu, Marius Naris, Colleen Garrett
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Publication number: 20240067657Abstract: The present invention relates to novel Amido-Substituted Heterocycle Compounds of Formula (I): and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, R7, and R8 are as defined herein. The present invention also relates to compositions comprising at least one Amido-Substituted Heterocycle Compound, and methods of using the Amido-Substituted Heterocycle Compounds for treating or preventing a herpesvirus infection in a patient.Type: ApplicationFiled: December 21, 2021Publication date: February 29, 2024Applicant: Merck Sharp & Dohme LLCInventors: Kira A. Armacost, Richard Thaddeus Berger, Jr., Andrew J. Cooke, Christopher Douglas Cox, Brendan M. Crowley, Marc Labroli, Michael Aaron Plotkin, Izzat Tiedje Raheem, Anthony W. Shaw, Kelly-Ann S. Schlegel, Jason W. Skudlarek, Ling Tong
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Patent number: 11633087Abstract: An endoscope manipulator for performing robot-assisted endoscope manipulation comprises a movable robot base with a hollow trunk and a vertical lifting joint; a passive joint set with one end mounted to an upper end of the vertical lifting joint, for manually setting an initial pose of the endoscope; an active joint set mounted to another end of the passive joint set, for adjusting pose control of the endoscope intra-operatively; and a compliant endoscope holder mountable to an end-effector of the active joint set, which passively changes to a compliant state upon an external force exceeding a threshold being applied to an endoscopic lens held by the compliant endoscope holder.Type: GrantFiled: August 7, 2019Date of Patent: April 25, 2023Assignee: The Chinese University of Hong KongInventors: Yunhui Liu, Chi-Fai Michael Tong, Fangxun Zhong, Zerui Wang, Hiu-man Yip
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Patent number: 11094134Abstract: Exemplary systems and methods are directed to generating synthetic data for computer vision. A processing device generates a synthetic three-dimensional (3D) image of an object. A background image is selected, and a composite image is generated by combining the 3D image of the object and the background image. The processing device simulates: reflection or emission of at least one type of radiant energy from the surface of the object and/or the background according to a set of parameters associated with at least one of the object and the background image; and a reflectance or emittance measurement of the at least one type of radiant energy from the surface of the object by a sensor device configured for detecting the at least one type of radiant energy. The processing device generates a plurality of two-dimensional (2D) simulated images of different perspectives of the object based on simulation data.Type: GrantFiled: August 13, 2020Date of Patent: August 17, 2021Assignee: BOOZ ALLEN HAMILTON INC.Inventors: Brandon Fallin, Dave Babbitt, Rory Thomas Burke, Paul McLone Carson, Cornelius Griggs, Kevin Green, Andrew Kalukin, Andre Tai Nguyen, David Sanborn, Douglas James Sanborn, Jacob Stevens-Haas, Alexander Tejada, James J. Ter Beest, Michael Tong
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Patent number: 10909705Abstract: A computer-implemented method for assessing an image sentiment. The method can include receiving an image to identify a region of interest in the image; determining an image sentiment value associated with the image based on the region of interest, or a classification of the image; and displaying an indication of the image sentiment value with a spatial (e.g. geographical) location.Type: GrantFiled: February 22, 2019Date of Patent: February 2, 2021Assignee: BOOZ ALLEN HAMILTON INC.Inventors: Catherine Ordun, Andrea Blackwell, Jo Clark, Erin Bradford, Nathan Schwan, Saba Ali, Michael Joyce, Nat Burgwyn, Kevin Chiu, Carver Sorensen, Michael Tong
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Publication number: 20200273189Abstract: A computer-implemented method for assessing an image sentiment. The method can include receiving an image to identify a region of interest in the image; determining an image sentiment value associated with the image based on the region of interest, or a classification of the image; and displaying an indication of the image sentiment value with a spatial (e.g. geographical) location.Type: ApplicationFiled: February 22, 2019Publication date: August 27, 2020Applicant: Booz Allen Hamilton Inc.Inventors: Catherine Ordun, Andrea Blackwell, Jo Clark, Erin Bradford, Nathan Schwan, Saba Ali, Michael Joyce, Nat Burgwyn, Kevin Chiu, Carver Sorensen, Michael Tong
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Publication number: 20200046441Abstract: An endoscope manipulator for performing robot-assisted endoscope manipulation comprises a movable robot base with a hollow trunk and a vertical lifting joint; a passive joint set with one end mounted to an upper end of the vertical lifting joint, for manually setting an initial pose of the endoscope; an active joint set mounted to another end of the passive joint set, for adjusting pose control of the endoscope intra-operatively; and a compliant endoscope holder mountable to an end-effector of the active joint set, which passively changes to a compliant state upon an external force exceeding a threshold being applied to an endoscopic lens held by the compliant endoscope holder.Type: ApplicationFiled: August 7, 2019Publication date: February 13, 2020Inventors: Yunhui LIU, Chi-Fai Michael TONG, Fangxun ZHONG, Zerui WANG, Hiu-man YIP
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Patent number: 9654951Abstract: An automatic distress alarming method includes that: A. a distress alarm automatically sends out a sound and light alarming signal; B. the distress alarm automatically sends a distress signal and a GPS signal to a mobile phone; C. the distress alarm sends out the distress signal and the GPS signal by a manual operation; D. a disconnected distress alarm sends out the distress signal and the GPS signal. And its system includes a microprocessor U1, a driving chip U2, a wireless transmitting module U3, a switching circuit of an angular rate sensor, a GPS circuit, a storage device, a reset button, a manual operation alarming switch, a manual operation communicating switch and a disconnecting alarming button.Type: GrantFiled: May 2, 2012Date of Patent: May 16, 2017Inventors: Lai Ming Wu, Chui Ha Kung, Michael Tong Chang, Ka Ho Cheung, Heung Kai Chan, Choi Lam Cheung, Hon Wai Chan
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Publication number: 20170013431Abstract: An automatic distress alarming method includes that: A. a distress alarm automatically sends out a sound and light alarming signal; B. the distress alarm automatically sends a distress signal and a GPS signal to a mobile phone; C. the distress alarm sends out the distress signal and the GPS signal by a manual operation; D. a disconnected distress alarm sends out the distress signal and the GPS signal. And its system includes a microprocessor U1, a driving chip U2, a wireless transmitting module U3, a switching circuit of an angular rate sensor, a GPS circuit, a storage device, a reset button, a manual operation alarming switch, a manual operation communicating switch and a disconnecting alarming button.Type: ApplicationFiled: May 2, 2012Publication date: January 12, 2017Inventors: Lai Ming Wu, Chui Ha Kung, Michael Tong Chang, Ka Ho Cheung, Heung Kai Chan, Choi Lam Cheung, Hon Wai Chan
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Patent number: D293348Type: GrantFiled: April 23, 1985Date of Patent: December 22, 1987Assignee: Playart LimitedInventor: Michael Tong