Abstract: Constitutive expression of the tumor suppressor genes p53 and IRF1 (interferon regulatory factor 1) is required for the maintenance of the cellular growth control during genotoxic damage or abberant proliferation. A transcriptional regulatory element within the promoter region of both the p53 and IRF-1 genes which binds a positive transcription factor, denoted GAAP-1 or GAAP-2 (IRF1 p53 common sequence binding factor). The invention relates to the identification and cloning of the GAAP-1 (or GAAP-2 cDNA and to the identification of the encoded protein corresponding to the 75 kDa product of the alternatively sliced PRDII-BF1 messenger RNA precursor.

Abstract: Water-soluble polypeptides having high affinity for interferons &agr; and &bgr;; DNA sequences and expression cells; a preparation method therefor; drugs; compositions containing same; and uses thereof as a diagnostic agent or for producing antibodies.

Abstract: The disclosure includes a carton concaving device capable of manipulating and maintaining the shape of a carton being sealed on a packaging machine. The device has a shaft which rotates with the movement of a conveyor chain thereby allowing for indexed movement of the device. The device has a plurality of rollers for deflecting the sidewalls of a carton about to be sealed at a top sealing station on a packaging machine. The device may be an add-on component or an integrated component of a packaging machine. The device reduces the number of bulged cartons being dispensed from a packaging machine.

Abstract: The subject rotor comprises a disklike body having hub and rim sections joined by a web section. The body is cast, molded or otherwise suitably formed of powdered silicon (and a binder, if necessary, to make it retain its shape until finally treated) which is reaction bonded to convert the silicon particles into a unitary mass. During the casting, molding or other forming step, one or more reinforcing rings of hot pressed silicon nitride or other suitable ceramic are embedded in the body. The ceramic selected must be one which will unite with the silicon during the reaction bonding operation to make a unitary mass. The reinforcing ring or rings are located in regions exposed to unusual stress in the use of the rotor to achieve the required strength.

Abstract: The subject rotor comprises a disklike body having hub and rim sections joined by a web section. The body is cast, molded or otherwise suitably formed of powdered silicon (and a binder, if necessary, to make it retain its shape until finally treated) which is reaction bonded to convert the silicon particles into a unitary mass. During the casting, molding or other forming step, one or more reinforcing rings of hot pressed silicon nitride or other suitable ceramic are embedded in the body. The ceramic selected must be one which will unite with the silicon during the reaction bonding operation to make a unitary mass. The reinforcing ring or rings are located in regions exposed to unusual stress in the use of the rotor to achieve the required strength.