Abstract: The present invention relates to CD117 targeted LNP molecules for delivery of pro-apoptotic mRNA to hematopoietic stem cells (HSCs) and methods of use thereof for preconditioning a subject for hematopoietic stem cell therapy or to deplete the subject's HSC population for the treatment of a disease or disorder.

Abstract: A head and neck orientation retainer block for training young or adult athletes for their sport while keeping their head up to provide a safer way to play, and also to enhance their skill and vision of the game. It can be worn during practices with the team and if one chooses, to practice at home. The retainer is a wedge block protrusion placed under the central forward chin of the child or adult player, to allow the player to have a wider freedom of side to side lateral movement, while the player's head is maintained horizontally for line of sight viewing purposes.