Patents by Inventor Michael Tropak

Michael Tropak has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMPOUNDS FOR THE TREATMENT OF LYSOSOMAL STORAGE DISEASES
    Publication number: 20150272951
    Abstract: A method of treating a lysosomal storage disease comprises administering a pyrimethamine derivative to a subject in need thereof.
    Type: Application
    Filed: June 2, 2015
    Publication date: October 1, 2015
    Inventors: Don MAHURAN, Michael TROPAK, Marco CIUFOLINI
  • COMPOUNDS FOR THE TREATMENT OF LYSOSOMAL STORAGE DISEASES
    Publication number: 20110195985
    Abstract: A method of treating a lysosomal storage disease comprises administering a pyrimethamine derivative to a subject in need thereof.
    Type: Application
    Filed: February 9, 2011
    Publication date: August 11, 2011
    Applicant: THE HOSPITAL FOR SICK CHILDREN
    Inventors: Don MAHURAN, Michael TROPAK, Marco CIUFOLINI
  • Real time methylumbelliferone-based assay
    Patent number: 7488721
    Abstract: A method is provided for determining the activity of an enzyme which releases methylumbelliferone (MU) from an MU-containing substrate wherein the enzyme has a pH optimum below the pKa of MU comprising: contacting a sample suspected of containing the enzyme with the MU-containing substrate at a pH suitable for activity of the enzyme to allow release of MU by the enzyme; contacting the sample with light of a wavelength in the range of about 310 nm to about 350 nm; determining fluorescence produced by the released MU, thereby determining the activity of the enzyme. This real time method provides improved diagnostic methods, for example for diseases associated with an abnormal level of activity of a glycosidase. The real time assay also can be used to screen compounds for their ability to modulate enzyme activity using MU-containing substrates.
    Type: Grant
    Filed: May 13, 2005
    Date of Patent: February 10, 2009
    Assignees: McMaster University, Hospital for Sick Children
    Inventors: Don Mahuran, Michael Tropak, Eric Brown
  • Treatment of tay sachs or sandhoff diseases by enhancing hexosaminidase activity
    Publication number: 20070066543
    Abstract: The invention provides a method for treating an animal suffering from a disease associated with reduced activity of a lysosomal hexosaminidase by administering to the animal an effective amount of a compound which increases the activity of the hexosaminidase.
    Type: Application
    Filed: May 21, 2004
    Publication date: March 22, 2007
    Applicants: The Hospital For Sick Children, The University Of British Columbia
    Inventors: Don Mahuran, Michael Tropak, Stephen Withers
  • Real time methylumbelliferone-based assay
    Publication number: 20060008862
    Abstract: A method is provided for determining the activity of an enzyme which releases methylumbelliferone (MU) from an MU-containing substrate wherein the enzyme has a pH optimum below the pKa of MU comprising: contacting a sample suspected of containing the enzyme with the MU-containing substrate at a pH suitable for activity of the enzyme to allow release of MU by the enzyme; contacting the sample with light of a wavelength in the range of about 310 nm to about 350 nm; determining fluorescence produced by the released MU, thereby determining the activity of the enzyme. This real time method provides improved diagnostic methods, for example for diseases associated with an abnormal level of activity of a glycosidase. The real time assay also can be used to screen compounds for their ability to modulate enzyme activity using MU-containing substrates.
    Type: Application
    Filed: May 13, 2005
    Publication date: January 12, 2006
    Inventors: Don Mahuran, Michael Tropak, Eric Brown, Jan Blanchard