Patents by Inventor Michael Ujhelyi

Michael Ujhelyi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 8475468
    Abstract: A method and apparatus for accessing the pericardial space which provides for stable short term or long term placement of a delivery catheter or cannula having its distal most end located in the pericardial space. The catheter or cannula may be introduced into the pericardial space either transvenously through the wall of a heart chamber or transthoracically by penetrating the chest wall and the pericardium. Some embodiments are provided with a mechanism for stabilizing the distal end of the catheter or cannula, which mechanism may employ an extensible elastic, generally tubular member located at the distal end of the catheter or cannula. The device may be provided with a mechanism for extending the tubular member longitudinally, causing its diameter to diminish substantially.
    Type: Grant
    Filed: June 26, 2003
    Date of Patent: July 2, 2013
    Assignee: Medtronic, Inc.
    Inventors: Michael E. Leckrone, Timothy G. Laske, Michael Ujhelyi
  • Publication number: 20070282259
    Abstract: A catheter body includes an exit port over which a pressure responsive sleeve is formed that allows material to exit a lumen of the catheter body at a given pressure. In one embodiment, a surface of the sleeve is approximately flush with a surface of the catheter body.
    Type: Application
    Filed: May 29, 2007
    Publication date: December 6, 2007
    Inventors: Mary Morris, Timothy Laske, Kenneth Heruth, Michael Ujhelyi, Jesus Casas, David Olson
  • Publication number: 20070203473
    Abstract: A medical delivery system for delivering a fluid to a desired location within a body that includes a first member having an aperture, and a second member adapted to be positioned over the first member. The fluid to be delivered is contained within a fluid storage device, formed by at least one of the first member and the second member. The medical delivery system includes means for repositioning the first member relative to the second member between a first state preventing passage of the fluid through the aperture and a second state enabling passage of the fluid outward from the fluid storage device through the aperture.
    Type: Application
    Filed: February 16, 2007
    Publication date: August 30, 2007
    Inventors: Michael Ujhelyi, Rahul Mehra, Xiaoyi Min
  • Patent number: 7207988
    Abstract: A method and apparatus for accessing the pericardial space which provides for stable short term or long term placement of a delivery catheter or cannula having its distal most end located in the pericardial space. The catheter or cannula may be introduced into the pericardial space either transvenously through the wall of a heart chamber or transthoracically by penetrating the chest wall and the pericardium. Some embodiments are provided with a mechanism for stabilizing the distal end of the catheter or cannula, which mechanism may employ an extensible elastic, generally tubular member located at the distal end of the catheter or cannula. The device may be provided with a mechanism for extending the tubular member longitudinally, causing its diameter to diminish substantially.
    Type: Grant
    Filed: June 26, 2003
    Date of Patent: April 24, 2007
    Assignee: Medtronic Inc.
    Inventors: Michael E. Leckrone, Timothy G. Laske, Michael Ujhelyi
  • Publication number: 20070027394
    Abstract: Control of conduction through a heart is described. A lead with a proximal end and a distal end is provided. The distal end of the lead is inserted into a target area. An agent is delivered through the lead to the target area. Delivery of the agent is monitored via a closed loop feedback system.
    Type: Application
    Filed: July 29, 2005
    Publication date: February 1, 2007
    Inventors: Michael Ujhelyi, Daniel Sigg
  • Publication number: 20060224421
    Abstract: A data collection system includes remote, implantable sensors for monitoring one or more patient parameters, collecting and processing data from those sensors and utilizing that data in the performance of a clinical study of a drug or other pharmacological agent. The system assists with preparation of a protocol for a clinical trial; presentation of that protocol; assuring compliance with the protocol; and generating useful results from data collected via the system and externally for presentation to an approval forum.
    Type: Application
    Filed: March 31, 2005
    Publication date: October 5, 2006
    Inventors: John St. Ores, Sarah Audet, James Carney, Janell Gottesman, Adrianus Donders, Michael Ujhelyi
  • Publication number: 20060224326
    Abstract: A data collection system includes remote, implantable sensors for monitoring one or more patient parameters, collecting and processing data from those sensors and utilizing that data in the performance of a clinical study of a drug or other pharmacological agent. The system assists with preparation of a protocol for a clinical trial; presentation of that protocol; assuring compliance with the protocol; and generating useful results from data collected via the system and externally for presentation to an approval forum.
    Type: Application
    Filed: March 31, 2005
    Publication date: October 5, 2006
    Inventors: John St. Ores, Sarah Audet, James Carney, Janell Gottesman, Adrianus Donders, Michael Ujhelyi
  • Publication number: 20060128647
    Abstract: Novel oligonucleotides and methods of treating a cardiac disease or disorder using the same are provided. The oligonucleotides are useful in modulating the expression of the connexin 43 protein and may be combined with other biologically active agents and compositions to treat cardiac disease. Methods of modulating connexin expression include the suppression of the expression of connexin 43 and the inducement of expression of connexin 45.
    Type: Application
    Filed: December 21, 2004
    Publication date: June 15, 2006
    Inventors: Daniel Sigg, Michael Ujhelyi, James Coles, Rudolfo Padua
  • Publication number: 20060069410
    Abstract: A method and system is provided for responding, from internally within a patient, to an atrial arrhythmia in a heart including measuring from within the patient at least one electrocardiogram characteristic indicative of the atrial arrhythmia, and controlling from within the patient drug therapy delivery to the patient responsive to measuring the at least one electrocardiogram characteristic. Drug therapy is initiated to the patient responsive to measuring the at least one electrocardiogram characteristic. According to one aspect of the present invention, the drug therapy is staged within the patient prior to measuring the at least one electrocardiogram characteristic. According to another example embodiment, the heart is paced from within the patient at a predefined rate responsive to measuring the at least one electrocardiogram characteristic, pacing occurring alone, or in combination with drug therapy.
    Type: Application
    Filed: October 6, 2005
    Publication date: March 30, 2006
    Inventors: Rahul Mehra, George Klein, Michael Ujhelyi
  • Publication number: 20050244377
    Abstract: The present invention is directed toward methods for regulating biological pacemaking activity and devices used in such regulation. Such regulation can be accomplished by introducing genetic material to the heart by transfecting heart cells of the atrium or ventricle with an oligonucleotide, small interfering RNA, that silence KCNJ2, and suppress the IK1 current. Suppression (or silencing) of KCNJ2 subsequently induces pacemaker-like activities in previously regular myocytes. This invention provides for methods of targeted delivery using a fluid delivery catheter. Such a catheter allows the targeting of a specific area in the atrium or the ventricle of the heart. Also, combination methods of treating arrhythmia with traditional device-based therapies (e.g., pacemakers and defibrillators) and an oligonucleotide of the subject invention.
    Type: Application
    Filed: December 22, 2004
    Publication date: November 3, 2005
    Inventors: Daniel Sigg, James Coles, Michael Ujhelyi, Rudy Padua, Daisy Cross, William Kaemmerer
  • Publication number: 20050177135
    Abstract: A sympatholytic cardiovascular agent delivered by a drug delivery pump to a central nervous system site to alleviate symptoms and otherwise treat heart failure (HF) and pathologies associated with HF. The drug delivery pump can be external or implantable infusion pump (IIP) coupled with a drug infusion catheter extending to the site. A patient activator can command delivery of a dosage and/or an implantable heart monitor (IHM) coupled with a sensor can detect physiologic parameters associated with HF (or pathologies associated with HF) and trigger dosage delivery. The IIP and IHM can be combined into a single implantable medical device (IMD) or can constitute separate IMDs that communicate by any of known communication mechanisms. The sympatholytic cardiovascular agent is one of the group consisting of an alpha-adrenergic agonist and an alpha2-adrenergic agonist, e.g.
    Type: Application
    Filed: February 6, 2004
    Publication date: August 11, 2005
    Inventors: Keith Hildebrand, Michael Ujhelyi, Xiaohong Zhou, Daniel Sigg, Linda Page
  • Publication number: 20050177097
    Abstract: A sympatholytic cardiovascular agent delivered by a drug delivery pump to a central nervous system site to alleviate symptoms of acute or chronic cardiac insult or impaired cardiac performance. The drug delivery pump can be external or implantable infusion pump (IIP) coupled with a drug infusion catheter extending to the site. A patient activator can command delivery of a dosage and/or an implantable heart monitor (IHM) coupled with a sensor can detect physiologic parameters associated with cardiac insult or impaired cardiac performance and trigger dosage delivery. The IIP and IHM can be combined into a single implantable medical device (IMD) or can constitute separate IMDs that communicate by any of known communication mechanisms. The sympatholytic cardiovascular agent is one of the group consisting of an alpha-adrenergic agonist and an alpha2-adrenergic agonist (e.g.
    Type: Application
    Filed: July 30, 2004
    Publication date: August 11, 2005
    Inventors: Keith Hildebrand, Michael Ujhelyi, Xiaohong Zhou, Daniel Sigg, Linda Page
  • Publication number: 20050165466
    Abstract: Methods and systems for transvenously accessing the pericardial space via the vascular system and atrial wall, particularly through the superior vena cava and right atrial wall, to deliver treatment in the pericardial space are disclosed. A steerable instrument is advanced transvenously into the right atrium of the heart, and a distal segment is deflected into the right atrial appendage. A fixation catheter is advanced employing the steerable instrument to affix a distal fixation mechanism to the atrial wall. A distal segment of an elongated medical device, e.g., a therapeutic catheter or an electrical medical lead, is advanced through the fixation catheter lumen, through the atrial wall, and into the pericardial space. The steerable guide catheter is removed, and the elongated medical device is coupled to an implantable medical device subcutaneously implanted in the thoracic region. The fixation catheter may be left in place.
    Type: Application
    Filed: December 1, 2004
    Publication date: July 28, 2005
    Inventors: Mary Morris, Kenneth Gardeski, Michael Ujhelyi, Michael Leckrone
  • Publication number: 20050159783
    Abstract: Control of defibrillation therapy delivered by implantable medical devices (IMDS) using hemodynamic sensor feedback is disclosed. The hemodynamic sensor feedback allows for increased control over application of atrial defibrillation therapy. Specifically, the therapy is delivered when a fibrillation episode results in a discrete loss of hemodynamic function. Defibrillation therapy is thus withheld for hemodynamically benign arrhythmias.
    Type: Application
    Filed: January 16, 2004
    Publication date: July 21, 2005
    Inventors: Douglas Hettrick, David Euler, Eduardo Warman, Michael Ujhelyi, Rahul Mehra, Paul Ziegler, Shailesh Kumar Musley, Charles Distad, David Ritscher
  • Publication number: 20050154370
    Abstract: Methods and systems for transvenously accessing the pericardial space via the vascular system and atrial wall, particularly through the superior vena cava and right atrial wall, to deliver a pharmacologic agent, particularly a NO-donor drug, to the heart are disclosed. A proximal connector of an infusion catheter is coupled to an infusion pump, and a distal catheter segment having a distal infusion catheter lumen end opening is disposed in the pericardial space. The implantable infusion pump is operable in conjunction with an implantable ischemia monitor to monitor the ischemic state and trigger delivery or regulate the periodic delivery of the pharmacologic agent to optimally treat ischemia. The patient may operate a patient activator that the patient when feeling ischemia symptoms to transmit a signal that is received by the implantable infusion pump and triggers delivery of a bolus and/or continuous infusion.
    Type: Application
    Filed: December 1, 2004
    Publication date: July 14, 2005
    Inventors: Daniel Sigg, Michael Ujhelyi, Mary Morris
  • Publication number: 20050028816
    Abstract: Methods for easing a patient's pain and anxiety from atrial or ventricular defibrillation are disclosed. The methods include causing the patient to inhale a medical gas prior to activation of a atrial defibrillation device or subsequent to activation of a ventricular defibrillation device. In the former case, the inhalation produces analgesia, anxiolysis or anterograde amnesia prior to, during and after the atrial defibrillation. In the latter case, the inhalation produces analgesia, anxiolysis or anterograde amnesia.
    Type: Application
    Filed: July 31, 2003
    Publication date: February 10, 2005
    Applicant: AGA Linde Healthcare
    Inventors: Royce Fishman, Michael Ujhelyi
  • Publication number: 20040087938
    Abstract: A method and apparatus for accessing the pericardial space which provides for stable short term or long term placement of a delivery catheter or cannula having its distal most end located in the pericardial space. The catheter or cannula may be introduced into the pericardial space either transvenously through the wall of a heart chamber or transthoracically by penetrating the chest wall and the pericardium. Some embodiments are provided with a mechanism for stabilizing the distal end of the catheter or cannula, which mechanism may employ an extensible elastic, generally tubular member located at the distal end of the catheter or cannula. The device may be provided with a mechanism for extending the tubular member longitudinally, causing its diameter to diminish substantially.
    Type: Application
    Filed: June 26, 2003
    Publication date: May 6, 2004
    Applicant: Medtronic, Inc.
    Inventors: Michael E. Leckrone, Timothy G. Laske, Michael Ujhelyi
  • Publication number: 20040024435
    Abstract: A method and apparatus for accessing the pericardial space which provides for stable short term or long term placement of a delivery catheter or cannula having its distal most end located in the pericardial space. The catheter or cannula may be introduced into the pericardial space either transvenously through the wall of a heart chamber or transthoracically by penetrating the chest wall and the pericardium. Some embodiments are provided with a mechanism for stabilizing the distal end of the catheter or cannula, which mechanism may employ an extensible elastic, generally tubular member located at the distal end of the catheter or cannula. The device may be provided with a mechanism for extending the tubular member longitudinally, causing its diameter to diminish substantially.
    Type: Application
    Filed: June 26, 2003
    Publication date: February 5, 2004
    Inventors: Michael E. Leckrone, Timothy G. Laske, Michael Ujhelyi
  • Patent number: 6613062
    Abstract: A method and apparatus for accessing the pericardial space which provides for stable short term or long term placement of a delivery catheter or cannula having its distal most end located in the pericardial space. The catheter or cannula may be introduced into the pericardial space either transvenously through the wall of a heart chamber or transthoracically by penetrating the chest wall and the pericardium. Some embodiments are provided with a mechanism for stabilizing the distal end of the catheter or cannula, which mechanism may employ an extensible elastic, generally tubular member located at the distal end of the catheter or cannula. The device may be provided with a mechanism for extending the tubular member longitudinally, causing its diameter to diminish substantially.
    Type: Grant
    Filed: October 29, 1999
    Date of Patent: September 2, 2003
    Assignee: Medtronic, inc.
    Inventors: Michael E. Leckrone, Timothy G. Laske, Michael Ujhelyi