Patents by Inventor Michael V. Guettler

Michael V. Guettler has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 8829237
    Abstract: This invention provide processes for producing carboxylic acid product, along with useful salts. The carboxylic acid product that is produced according to this invention is preferably a C2-C12 carboxylic acid. Among the salts produced in the process of the invention are ammonium salts.
    Type: Grant
    Filed: March 3, 2011
    Date of Patent: September 9, 2014
    Assignee: The Michigan Biotechnology Institute
    Inventors: Robert J. Hanchar, Susanne Kleff, Michael V. Guettler
  • Patent number: 8431373
    Abstract: Disclosed are recombinant microorganisms for producing organic acids. The recombinant microorganisms express a polypeptide that has the enzymatic activity of an enzyme that is utilized in the pentose phosphate cycle. The recombinant microorganism may include recombinant Actinobacillus succinogenes that has been transformed to express a Zwischenferment (Zwf) gene. The recombinant microorganisms may be useful in fermentation processes for producing organic acids such as succinic acid and lactic acid. Also disclosed are novel plasmids that are useful for transforming microorganisms to produce recombinant microorganisms that express enzymes such as Zwf.
    Type: Grant
    Filed: December 16, 2011
    Date of Patent: April 30, 2013
    Assignee: Michigan Biotechnology Institute
    Inventors: Jian Yi, Susanne Kleff, Michael V. Guettler
  • Patent number: 8431372
    Abstract: This invention is directed to methods of obtaining a high quantity of desired acid salt in a form that is relatively easy to recover. Particularly desired as a recovery product is an organic acid. A salt form of the desired organic acid is formed that is relatively high in concentration and that is relatively soluble in an aqueous medium. The method includes a step of fermenting a fermentable carbon source in the fermentation medium in the presence of a magnesium compound containing oxygen.
    Type: Grant
    Filed: June 19, 2009
    Date of Patent: April 30, 2013
    Assignee: MBI International
    Inventors: Michael V. Guettler, Robert J. Hanchar, Denise S. Rumler, Susanne Kleff
  • Publication number: 20120225095
    Abstract: This invention provide processes for producing carboxylic acid product, along with useful salts. The carboxylic acid product that is produced according to this invention is preferably a C2-C12 carboxylic acid. Among the salts produced in the process of the invention are ammonium salts.
    Type: Application
    Filed: March 3, 2011
    Publication date: September 6, 2012
    Applicant: MICHIGAN BIOTECHNOLOGY INSTITUTE
    Inventors: Robert J. Hanchar, Susanne Kleff, Michael V. Guettler
  • Publication number: 20120164703
    Abstract: Disclosed are recombinant microorganisms for producing organic acids. The recombinant microorganisms express a polypeptide that has the enzymatic activity of an enzyme that is utilized in the pentose phosphate cycle. The recombinant microorganism may include recombinant Actinobacillus succinogenes that has been transformed to express a Zwischenferment (Zwf) gene. The recombinant microorganisms may be useful in fermentation processes for producing organic acids such as succinic acid and lactic acid. Also disclosed are novel plasmids that are useful for transforming microorganisms to produce recombinant microorganisms that express enzymes such as Zwf.
    Type: Application
    Filed: December 16, 2011
    Publication date: June 28, 2012
    Applicant: Michigan Biotechnology Institute
    Inventors: Jian YI, Susanne Kleff, Michael V. Guettler
  • Patent number: 8119377
    Abstract: Disclosed are recombinant microorganisms for producing organic acids. The recombinant microorganisms express a polypeptide that has the enzymatic activity of an enzyme that is utilized in the pentose phosphate cycle. The recombinant microorganism may include recombinant Actinobacillus succinogenes that has been transformed to express a Zwischenferment (Zwf) gene. The recombinant microorganisms may be useful in fermentation processes for producing organic acids such as succinic acid and lactic acid. Also disclosed are novel plasmids that are useful for transforming microorganisms to produce recombinant microorganisms that express enzymes such as Zwf.
    Type: Grant
    Filed: December 16, 2005
    Date of Patent: February 21, 2012
    Assignee: Michigan Biotechnology Institute
    Inventors: Jian Yi, Susanne Kleff, Michael V. Guettler
  • Publication number: 20100323416
    Abstract: This invention is directed to methods of obtaining a high quantity of desired acid salt in a form that is relatively easy to recover. Particularly desired as a recovery product is an organic acid. A salt form of the desired organic acid is formed that is relatively high in concentration and that is relatively soluble in an aqueous medium. The method includes a step of fermenting a fermentable carbon source in the fermentation medium in the presence of a magnesium compound containing oxygen.
    Type: Application
    Filed: June 19, 2009
    Publication date: December 23, 2010
    Applicant: MBI International
    Inventors: Michael V. Guettler, Robert J. Hanchar, Denise S. Rumler, Susanne Kleff
  • Publication number: 20080305533
    Abstract: Disclosed are recombinant microorganisms for producing organic acids. The recombinant microorganisms express a polypeptide that has the enzymatic activity of an enzyme that is utilized in the pentose phosphate cycle. The recombinant microorganism may include recombinant Actinobacillus succinogenes that has been transformed to express a Zwischenferment (Zwf) gene. The recombinant microorganisms may be useful in fermentation processes for producing organic acids such as succinic acid and lactic acid. Also disclosed are novel plasmids that are useful for transforming microorganisms to produce recombinant microorganisms that express enzymes such as Zwf.
    Type: Application
    Filed: December 16, 2005
    Publication date: December 11, 2008
    Applicant: ORACLE INTERNATIONAL CORPORATION
    Inventors: Jian Yi, Susanne Kleff, Michael V. Guettler
  • Patent number: 6261825
    Abstract: A method of producing amino acids by culturing an amino acid auxotroph of a biologically pure strain of a type I methylotrophic bacterium of the genus Bacillus which exhibits sustained growth at 50° C. using methanol as a carbon and energy source and requiring vitamin B12 and biotin is provided.
    Type: Grant
    Filed: March 20, 1991
    Date of Patent: July 17, 2001
    Assignee: Regents of the University of Minnesota
    Inventors: Richard S. Hanson, Michael C. Flickinger, Frederick J. Schendel, Michael V. Guettler
  • Patent number: 5723322
    Abstract: A fermentation process for making succinic acid in high concentrations employs a bacteria obtained from the rumen contents of cattle. A preferred bacteria is Bacterium 130Z (ATCC No. 55618).
    Type: Grant
    Filed: January 11, 1996
    Date of Patent: March 3, 1998
    Assignee: Michigan Biotechnology Institute
    Inventors: Michael V. Guettler, Mahendra K. Jain, Bhupendra K. Soni
  • Patent number: 5573931
    Abstract: A method for producing succinic acid in high concentration by fermentation employs a variant of strain 130Z which is resistant to concentrations of about 1 g/l to about 8 g/l of sodium monofluoroacetate. The variant produces succinic acid in concentrations of about 80 g/l to about 110 g/l and the fermentation product contains less formic and acetic acids than the product obtained using the parent strain under identical conditions. The novel variants and a method of obtaining such variants also are described.
    Type: Grant
    Filed: August 28, 1995
    Date of Patent: November 12, 1996
    Assignee: Michigan Biotechnology Institute
    Inventors: Michael V. Guettler, Mahendra K. Jain, Denise Rumler
  • Patent number: 5521075
    Abstract: A method for making succinic acid employs a fluoroacetate resistant variant of Anaerobiospirillum succiniciproducens. The fluoroacetate variant produces a succinic acid product which contains less acetic acid than the product obtained using the parent strain under identical conditions. A preferred variant FA-10 is obtained from A. succiniciproducens (ATCC No. 29305). A method of obtaining the variant also is described.
    Type: Grant
    Filed: December 19, 1994
    Date of Patent: May 28, 1996
    Assignee: Michigan Biotechnology Institute
    Inventors: Michael V. Guettler, Mahendra K. Jain
  • Patent number: 5504004
    Abstract: A fermentation process for making succinic acid in high concentrations employs a bacteria obtained from the rumen contents of cattle. A preferred bacteria is Bacterium 130Z (ATCC No. 55618).
    Type: Grant
    Filed: December 20, 1994
    Date of Patent: April 2, 1996
    Assignee: Michigan Biotechnology Institute
    Inventors: Michael V. Guettler, Mahendra K. Jain, Bhupendra K. Soni