Patents by Inventor Michael V. Miles

Michael V. Miles has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Biomarkers and methods for determining disease progression in nonalcoholic steatohepatitis (NASH)
    Patent number: 8871454
    Abstract: Diets high in saturated fat and fructose have been implicated in the development of obesity and nonalcoholic steatohepatitis (NASH) in humans. Provided herein are biomarkers, methods, and animal models useful for the investigation and non-invasive detection of NASH, including a non-invasive biomarker that could be used to establish disease severity, follow progression, and evaluate response to treatment in clinical trials for this increasingly prevalent disease.
    Type: Grant
    Filed: January 26, 2011
    Date of Patent: October 28, 2014
    Assignee: Children's Hospital Medical Center
    Inventors: Rohit Kohli, Stavra A. Xanthakos, Michael V. Miles
  • BIOMARKERS AND METHODS FOR DETERMINING DISEASE PROGRESSION IN NONALCOHOLIC STEATOHEPATITIS (NASH)
    Publication number: 20110212468
    Abstract: Diets high in saturated fat and fructose have been implicated in the development of obesity and nonalcoholic steatohepatitis (NASH) in humans. Provided herein are biomarkers, methods, and animal models useful for the investigation and non-invasive detection of NASH, including a non-invasive biomarker that could be used to establish disease severity, follow progression, and evaluate response to treatment in clinical trials for this increasingly prevalent disease.
    Type: Application
    Filed: January 26, 2011
    Publication date: September 1, 2011
    Inventors: Rohit Kohli, Stavra A. Xanthakos, Michael V. Miles
  • Electrochemical analysis of coenzyme Q10 and reduced coenzyme Q10
    Patent number: 6984308
    Abstract: This invention relates to an apparatus and method for the simultaneous and rapid determination of CoQ10 and CoQ10H2 concentrations in human samples using HPLC-EC. The electrochemical reactions are monitored at electrodes that measure the current produced by the reduction of the hydroquinone group of CoQ10 or by the oxidation of the hydroquinol group of CoQ10H2.
    Type: Grant
    Filed: March 4, 2002
    Date of Patent: January 10, 2006
    Assignee: Cincinnati Children's Hospital Research Foundation
    Inventors: Peter H. Tang, Ton de Grauw, Michael V. Miles
  • Electrochemical analysis of coenzyme Q10 and reduced coenzyme Q10
    Publication number: 20020125193
    Abstract: This invention relates to an apparatus and method for the simultaneous and rapid determination of CoQ10 and CoQ10H2 concentrations in human samples using HPLC-EC. The electrochemical reactions are monitored at electrodes that measure the current produced by the reduction of the hydroquinone group of CoQ10 or by the oxidation of the hydroquinol group of CoQ10H2.
    Type: Application
    Filed: March 4, 2002
    Publication date: September 12, 2002
    Inventors: Peter H. Tang, Ton de Grauw, Michael V. Miles