Patents by Inventor Michael V. Sofroniew

Michael V. Sofroniew has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Non-ionic and thermoresponsive diblock copolypeptide hydrogels for delivery of molecules and cells
    Patent number: 11298424
    Abstract: The present invention is directed to copolypeptide hydrogels (DCH) containing non-ionic hydrophilic residues (DCHEO), incorporation of thermoresponsive elements into DCHEO, to generate thermoresponsive DCH (DCHT), and hydrogels that include a combination of DCHEO and DCHT. The invention includes preparation, uses, compositions containing the hydrogels and methods of tuning the hydrogels. The hydrogels can be used to deliver an agent or cells to an organism.
    Type: Grant
    Filed: October 1, 2015
    Date of Patent: April 12, 2022
    Assignee: The Regents of the University of California
    Inventors: Timothy J. Deming, Michael V. Sofroniew, Shanshan Zhang
  • NON-IONIC AND THERMORESPONSIVE DIBLOCK COPOLYPEPTIDE HYDROGELS FOR DELIVERY OF MOLECULES AND CELLS
    Publication number: 20170296672
    Abstract: The present invention is directed to copolypeptide hydrogels (DCH) containing non-ionic hydrophilic residues (DCHEO), incorporation of thermoresponsive elements into DCHEO, to generate thermoresponsive DCH (DCHT), and hydrogels that include a combination of DCHEO and DCHT. The invention includes preparation, uses, compositions containing the hydrogels and methods of tuning the hydrogels. The hydrogels can be used to deliver an agent or cells to an organism.
    Type: Application
    Filed: October 1, 2015
    Publication date: October 19, 2017
    Applicant: The Regents fo the University of California
    Inventors: Timothy J. Deming, Michael V. Sofroniew, Shanshan Zhang
  • SYNTHETIC DIBLOCK COPOLYPEPTIDE HYDROGELS FOR USE IN THE CENTRAL NERVOUS SYSTEM
    Publication number: 20140286865
    Abstract: This invention relates, e.g., to a composition suitable for administration to the central nervous system (CNS), comprising a block copolypeptide hydrogel, which comprises a biologically active material that is mixed with the hydrogel or that is attached to the polypeptide chain of the hydrogel, wherein the composition is suitable for administration to the CNS. Also disclosed are methods of making and using compositions of the invention as depots or as scaffolds for cell migration, and pharmaceutical compositions and kits for implementing methods of the invention.
    Type: Application
    Filed: February 18, 2014
    Publication date: September 25, 2014
    Applicant: The Regents of the University of California
    Inventors: Timothy J. Deming, Michael V. Sofroniew, Chu-Ya Yang, BingBing Song, Yan Ao
  • Synthetic diblock copolypeptide hydrogels for use in the central nervous system
    Patent number: 8691204
    Abstract: This invention relates, e.g., to a composition suitable for administration to the central nervous system (CNS), comprising a block copolypeptide hydrogel, which comprises a biologically active material that is mixed with the hydrogel or that is attached to the polypeptide chain of the hydrogel, wherein the composition is suitable for administration to the CNS. Also disclosed are methods of making and using compositions of the invention as depots or as scaffolds for cell migration, and pharmaceutical compositions and kits for implementing methods of the invention.
    Type: Grant
    Filed: February 18, 2010
    Date of Patent: April 8, 2014
    Assignee: The Regents of the University of California
    Inventors: Timothy J. Deming, Michael V. Sofroniew, Chu-Ya Yang, BingBing Song, Yan Ao
  • SYNTHETIC DIBLOCK COPOLYPEPTIDE HYDROGELS FOR USE IN THE CENTRAL NERVOUS SYSTEM
    Publication number: 20120093722
    Abstract: This invention relates, e.g., to a composition suitable for administration to the central nervous system (CNS), comprising a block copolypeptide hydrogel, which comprises a biologically active material that is mixed with the hydrogel or that is attached to the polypeptide chain of the hydrogel, wherein the composition is suitable for administration to the CNS. Also disclosed are methods of making and using compositions of the invention as depots or as scaffolds for cell migration, and pharmaceutical compositions and kits for implementing methods of the invention.
    Type: Application
    Filed: February 18, 2010
    Publication date: April 19, 2012
    Applicant: The Regents of the University of California
    Inventors: Timothy J. Deming, Michael V. Sofroniew, Chu-Ya Yang, BingBing Song, Yan Ao
  • Oriented Polymer Fibers and Methods for Fabricating Thereof
    Publication number: 20080290554
    Abstract: Devices for fabricating oriented polymer fibers, and methods for fabricating thereof by electropulling, are provided.
    Type: Application
    Filed: March 31, 2005
    Publication date: November 27, 2008
    Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Benjamin M. Wu, Michael V. Sofroniew, King-Ning Tu, Yuhuan Xu