Patents by Inventor Michael Van Brunt

Michael Van Brunt has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Cell lines
    Patent number: 10253345
    Abstract: There is provided inter alia a process for stabilizing a eukaryotic cell line which expresses PylRS and tRNAPyl and which is suitable for incorporation of a gene encoding a target protein containing one or more non-natural amino acids encoded by a nonsense codon which comprises culturing said cell line under conditions in which the adverse effect of tRNAPyl expression on cell viability and/or cell growth is reduced or eliminated.
    Type: Grant
    Filed: June 1, 2017
    Date of Patent: April 9, 2019
    Assignee: MEDIMMUNE LIMITED
    Inventors: Kenneth H. Grabstein, Michael Van Brunt, Marcello Marelli, William Brady, Jeffrey C. Johnson
  • Amino acid derivatives
    Patent number: 10214761
    Abstract: There are provided amino acid derivatives of formula V and VI as defined herein which are pyrrolysine analogs for use in bioconjugation processes.
    Type: Grant
    Filed: June 1, 2017
    Date of Patent: February 26, 2019
    Assignee: MEDIMMUNE LIMITED
    Inventors: Kenneth H. Grabstein, Michael Van Brunt, Marcello Marelli
  • Amino acid derivatives
    Patent number: 9981908
    Abstract: There are provided pyrrolysine analogs of the formulae (X), (I), (II), (V), (VI), (VII) and (VIII), in which the a, b, d, X, Y, Z, FG, R, R1, R2 and R3 are as defined in the claims, which are useful in bioconjugation processes and mutant proteins containing them.
    Type: Grant
    Filed: August 4, 2014
    Date of Patent: May 29, 2018
    Assignee: MedImmune Limited
    Inventors: Marcello Marelli, Michael van Brunt, Kenneth H. Grabstein
  • AMINO ACID DERIVATIVES
    Publication number: 20170306380
    Abstract: There are provided amino acid derivatives of formula V and VI as defined herein which are pyrrolysine analogs for use in bioconjugation processes.
    Type: Application
    Filed: June 1, 2017
    Publication date: October 26, 2017
    Inventors: Kenneth H. Grabstein, Michael Van Brunt, Marcello Marelli
  • CELL LINES
    Publication number: 20170306381
    Abstract: There is provided inter alia a process for stabilizing a eukaryotic cell line which expresses PylRS and tRNAPyl and which is suitable for incorporation of a gene encoding a target protein containing one or more non-natural amino acids encoded by a nonsense codon which comprises culturing said cell line under conditions in which the adverse effect of tRNAPyl expression on cell viability and/or cell growth is reduced or eliminated.
    Type: Application
    Filed: June 1, 2017
    Publication date: October 26, 2017
    Inventors: Kenneth H. Grabstein, Michael Van Brunt, Marcello Marelli, William Brady, Jeffrey C. Johnson
  • Cell lines
    Patent number: 9732367
    Abstract: There is provided inter alia a process for stabilizing a eukaryotic cell line which expresses PylRS and tRNAPyl and which is suitable for incorporation of a gene encoding a target protein containing one or more non-natural amino acids encoded by a nonsense codon which comprises culturing said cell line under conditions in which the adverse effect of tRNAPyl expression on cell viability and/or cell growth is reduced or eliminated.
    Type: Grant
    Filed: September 24, 2013
    Date of Patent: August 15, 2017
    Assignee: MEDIMMUNE LIMITED
    Inventors: Kenneth H. Grabstein, Michael Van Brunt, Marcello Marelli, William Brady, Jeffrey C. Johnson
  • Amino acid derivatives
    Patent number: 9670521
    Abstract: There are provided amino acid derivatives of formula V and VI as defined herein which are pyrrolysine analogs for use in bioconjugation processes.
    Type: Grant
    Filed: September 24, 2013
    Date of Patent: June 6, 2017
    Assignee: MEDIMMUNE LIMITED
    Inventors: Kenneth H. Grabstein, Michael Van Brunt, Marcello Marelli
  • Amino Acid Derivatives
    Publication number: 20160176811
    Abstract: There are provided pyrrolysine analogues of the formulae (X), (I), (II), (V), (VI), (VII) and (VIII), in which the a, b, d, X, Y, Z, FG, R, R1, R2 and R3 are as defined in the claims, which are useful in bioconjugation processes and mutant proteins containing them.
    Type: Application
    Filed: August 4, 2014
    Publication date: June 23, 2016
    Inventors: Marcello Marelli, Michael van Brunt, Kenneth H. Grabstein
  • CELL LINES
    Publication number: 20150259721
    Abstract: There is provided inter alia a process for stabilizing a eukaryotic cell line which expresses PylRS and tRNAPyl and which is suitable for incorporation of a gene encoding a target protein containing one or more non-natural amino acids encoded by a nonsense codon which comprises culturing said cell line under conditions in which the adverse effect of tRNAPyl expression on cell viability and/or cell growth is reduced or eliminated.
    Type: Application
    Filed: September 24, 2013
    Publication date: September 17, 2015
    Inventors: Kenneth H. Grabstein, Michael Van Brunt, Marcello Marelli, William Brady, Jeffrey Johnson
  • AMINO ACID DERIVATIVES
    Publication number: 20150251994
    Abstract: There are provided amino acid derivatives of formula V and VI as defined herein which are pyrrolysine analogs for use in bioconjugation processes.
    Type: Application
    Filed: September 24, 2013
    Publication date: September 10, 2015
    Inventors: Kenneth H. Grabstein, Michael Van Brunt, Marcello Marelli
  • Process for production of carebastine
    Patent number: 8067604
    Abstract: Processes are disclosed for preparing piperidine derivative compounds of the formulae I, II or III:
    Type: Grant
    Filed: November 22, 2010
    Date of Patent: November 29, 2011
    Assignee: Albany Molecular Research, Inc.
    Inventors: Harold Meckler, Ben Littler, Prasad Raje, Michael van Brunt, Paul F Vogt
  • PROCESS FOR PRODUCTION OF PIPERIDINE DERIVATIVES
    Publication number: 20110071295
    Abstract: Processes are disclosed for preparing piperidine derivative compounds of the formulae I, II or III: The processes involve reacting a compound of formula Ia, IIa or IIIa with isobutyrate or an isobutyrate equivalent.
    Type: Application
    Filed: November 30, 2010
    Publication date: March 24, 2011
    Applicant: ALBANY MOLECULAR RESEARCH, INC.
    Inventors: Harold MECKLER, Ben Littler, Prasad Raje, Michael Van Brunt, Paul F. Vogt
  • PROCESS FOR PRODUCTION OF CAREBASTINE
    Publication number: 20110065923
    Abstract: Processes are disclosed for preparing piperidine derivative compounds of the formulae I, II or III:
    Type: Application
    Filed: November 22, 2010
    Publication date: March 17, 2011
    Applicant: Albany Molecular Research, Inc.
    Inventors: Harold MECKLER, Benjamin J. Littler, Prasad Raje, Michael van Brunt, Paul F. Vogt
  • Process for production of piperidine derivatives
    Patent number: 7863452
    Abstract: Processes are disclosed for preparing piperidine derivative compounds of the formulae I, II or III: The processes involve reacting a compound of formula Ia, IIa or IIIa with isobutyrate or an isobutyrate equivalent.
    Type: Grant
    Filed: January 20, 2009
    Date of Patent: January 4, 2011
    Assignee: Albany Molecular Research, Inc.
    Inventors: Harold Meckler, Ben Littler, Prasad Raje, Michael van Brunt, Paul F Vogt
  • Process for production of carebastine
    Patent number: 7858798
    Abstract: Processes are disclosed for preparing piperidine derivative compounds of the formulae I, II or III:
    Type: Grant
    Filed: January 20, 2009
    Date of Patent: December 28, 2010
    Assignee: Albany Molecular Research, Inc.
    Inventors: Harold Meckler, Ben Littler, Prasad Raje, Michael van Brunt, Paul F Vogt
  • PROCESS FOR PRODUCTION OF CAREBASTINE
    Publication number: 20090137813
    Abstract: Processes are disclosed for preparing piperidine derivative compounds of the formulae I, II or III:
    Type: Application
    Filed: January 20, 2009
    Publication date: May 28, 2009
    Applicant: ALBANY MOLECULAR RESEARCH, INC.
    Inventors: Harold Meckler, Benjamin J. Littler, Prasad Raje, Michael Van Brunt, Paul F. Vogt
  • PROCESS FOR PRODUCTION OF PIPERIDINE DERIVATIVES
    Publication number: 20090124810
    Abstract: Processes are disclosed for preparing piperidine derivative compounds of the formulae I, II or III: The processes involve reacting a compound of formula Ia, IIa or IIIa with isobutyrate or an isobutyrate equivalent.
    Type: Application
    Filed: January 20, 2009
    Publication date: May 14, 2009
    Applicant: ALBANY MOLECULAR RESEARCH, INC.
    Inventors: Harold Meckler, Ben Littler, Prasad Raje, Michael van Brunt, Paul F. Vogt
  • Process for production of carebastine
    Patent number: 7498443
    Abstract: Processes are disclosed for preparing piperidine derivative compounds of the formulae I, II or III:
    Type: Grant
    Filed: September 17, 2004
    Date of Patent: March 3, 2009
    Assignee: Albany Molecular Research, Inc.
    Inventors: Harold Meckler, Benjamin J. Littler, Prasad Raje, Michael Van Brunt, Paul F. Vogt
  • Process for production of piperidine derivatives
    Patent number: 7498345
    Abstract: Processes are disclosed for preparing piperidine derivative compounds of the formulae I, II or III: The processes involve reacting a compound of formula Ia, IIa or IIIa with isobutyrate or an isobutyrate equivalent.
    Type: Grant
    Filed: September 17, 2004
    Date of Patent: March 3, 2009
    Assignee: Albany Molecular Research, Inc.
    Inventors: Harold Meckler, Benjamin J. Littler, Prasad Raje, Michael Van Brunt, Paul F. Vogt
  • Process for production of carebastine
    Publication number: 20060063933
    Abstract: Processes are disclosed for preparing piperidine derivative compounds of the formulae I, II or III:
    Type: Application
    Filed: September 17, 2004
    Publication date: March 23, 2006
    Applicant: AMR Technology, Inc.
    Inventors: Harold Meckler, Benjamin Littler, Prasad Raje, Michael Van Brunt, Paul Vogt