Abstract: A method is provided for cardiac pacing therapy guidance including: receiving an 3D or anatomic model and/or processing thereof, receiving location information of at least one heart conduction feature and/or processing thereof, receiving location information of at least one cardiac vein and/or processing thereof, receiving ECG recording data and/or processing thereof, determining a heart activation map relative to the model, and determining potential implant areas for implantation of at least one pacing system lead, such as for the purpose of outputting such information relating to the model and the potential implant areas for displaying thereof.

Abstract: A microfluidic chip device for the purification of radiochemical compounds includes a chip having an injection channel and intersecting branch channels with a plurality of valves are located along the injection channel and branch channels and configured to retain a plug of solution containing the radiochemical compound. The chip further includes a serpentine channel segment (for separation) coupled to the output of the injection channel. A high voltage power source advances the plug of solution through the purification region and into the downstream fraction collection channel. The chip includes a downstream fraction collection channel coupled to the serpentine channel segment and having an optical and radiation detection regions. One or more branch fraction channels intersect with the fraction collection channel and include valves located therein so that the radiochemical compound that is detected using a radiation detector is directed into the desired branch fraction channel for subsequent use.

Abstract: The present invention relates to a method to provide a mean temporal spatial isochrone (TSI) path relating to an ECG feature (wave form) of interest, such as the activation of the heart from a single point (QRS), relative to the heart in a torso while using an ECG measurement from an ECG recording device.

Abstract: A radiosynthesis system is disclosed that leverages droplet microfluidic radiosynthesis and its inherent advantages including reduction of reagent consumption and the ability to achieve high molar activity even when using low starting radioactivity. The radiosynthesis system enables the parallel synthesis of radiolabeled compounds using droplet-sized reaction volumes. In some embodiments, a single heater is used to create multiple reaction or synthesis sites. In other embodiments, separate heaters are used to create independently-controlled heating conditions at the multiple reaction or synthesis sites. In one embodiment, a four-heater setup was developed that utilizes a multi-reaction microfluidic chip and was assessed for the suitability with high-throughput radiosynthesis optimization. Replicates of several radiochemical operations including the full synthesis of various PET tracers revealed the platform to have high repeatability (e.g., consistent fluorination efficiency).

Abstract: The present invention relates to a method to be performed by a computing device part of or coupled to an ECG device for applying a marker element in a process of determining positions of a set of ECG electrodes as placed on a human torso relative to a 3D model of a body, preferably a torso model of the torso of the human body. The method includes receiving an imaging information recording relating to the human body from an optical imaging device, preferably a 3D imaging device. The optical imaging information includes imaging information of the exterior of the body, such as imaging information of the exterior of the torso, and imaging information of the marker element. The method also includes performing an image recognition on the imaging information for obtaining a presence determination, preferably a positive or negative determination, of the marker element in the imaging information.

Abstract: The present invention relates to a method to provide a mean temporal spatial isochrone (TSI) feature relating to an ECG feature (wave form) of interest, such as the activation of the heart from a single point (QRS), relative to the heart in a torso while using an ECG measurement from an ECG recording device.

Abstract: A chemical synthesis platform based on a particularly simple chip is described herein, where reactions take place atop a hydrophobic substrate patterned with a circular hydrophilic liquid trap. The overall supporting hardware (heater, rotating carousel of reagent dispensers, etc.) can be packaged into a very compact format (about the size of a coffee cup). We demonstrate the consistent synthesis of [18F]fallypride with high yield, and show that protocols optimized using a high-throughput optimization platform we have developed can be readily translated to this device with no changes or reoptimization.

Abstract: A method of performing high-throughput radio thin layer chromatography (radio-TLC) includes spotting a plurality of locations on one or more TLC plates with samples containing a radiochemical or a radiopharmaceutical, each location defining an individual lane on the one or more TLC plates for the respective samples. The one or more TLC plates are developed with a developing solution and dried. The TLC plates are imaged with an imaging device comprising a camera, wherein the image obtained from the camera comprises a field of view that contains regions of interest (ROIs) from the plurality of lanes. The ROIs in the images obtained from the camera may then be analyzed by the user. The ROIs may be used, for example, reaction optimization or for quality control check of the production of radiotracers.

Abstract: The invention relates to a method and a system for providing a representation of synchronicity of electrical activation of heart tissue. The method includes obtaining a three-dimensional model of electrical activation of the heart. The three-dimensional model includes a mesh with a plurality of nodes, each node having associated therewith a time delay between stimulation of the heart at a stimulation site and activation of the heart at that respective node. For each node a stimulus site is defined at the location of that node. For each node a modified three-dimensional model of electrical activation of the heart resulting from stimulation at that node is determined. For each node a measure for heart activation synchronicity for the heart based on stimulation at that node is determined A heart synchronicity map is determined representing a three-dimensional model of the heart, indicating at each node the respective measure for heart activation synchronicity.

Abstract: A microfluidic synthesis platform includes a microfluidic chip holder that has a computer controlled heating element and cooling element therein. A microfluidic chip is mountable in the microfluidic chip holder. The microfluidic chip is formed by a hydrophobic substrate having patterned thereon a hydrophilic reaction site and a plurality of hydrophilic channels or pathways extending outward from the hydrophilic reaction site and terminating at respective loading sites on the substrate, wherein the hydrophilic channels or pathways are tapered with an increasing width in an inward direction toward the hydrophilic reaction site.

Abstract: The present invention relates to a method to be performed by a computing device along with an ECG device for estimating an orientation of the heart based on 3-D imaging information taken from a torso, preferably applying a marker element in a process of determining an orientation of a heart, preferably in a torso model of the torso of the human body, more preferably a heart-torso model specifically including data pertaining to the heart of the, preferably human, body, the method being receiving information relating to the human body from a measurement source, such as dimensional measurement information input into the computing device from an input interface or an optical imaging device, preferably a 3D imaging device, the information being information of the exterior of the body, such as imaging information of the exterior of the torso, and determining chest dimensions, such as at the xyphoid position.

Abstract: The invention relates to a method and a system for providing a representation of synchronicity of electrical activation of heart tissue. The method includes obtaining a three-dimensional model of electrical activation of the heart. The three-dimensional model includes a mesh with a plurality of nodes, each node having associated therewith a time delay between stimulation of the heart at a stimulation site and activation of the heart at that respective node. For each node a stimulus site is defined at the location of that node. For each node a modified three-dimensional model of electrical activation of the heart resulting from stimulation at that node is determined. For each node a measure for heart activation synchronicity for the heart based on stimulation at that node is determined. A heart synchronicity map is determined representing a three-dimensional model of the heart, indicating at each node the respective measure for heart activation synchronicity.

Abstract: A volumetric microfluidic injector for capillary electrophoresis (CE) for highly repeatable sample injection has been designed and built to eliminate known injection bias in hydrodynamic injection. A defined volume from 1-10 nL or 0.1-100 nL of sample is confined in a defined region of a micro-valve PDMS microfluidic injector chip and electrophoretic potential is applied to drive sample into a separation device such as an embedded fused silica capillary for separation and detection. Using a 75 ?m ID capillary, the RSD of an absorbance peak area as low as 1.32% (n=11) is obtained. As a comparison, the time-dependent injection was tested using the same chip which resulted in an inferior repeatability.

Abstract: A computer implemented method for processing measurement data from electrocardiogram, ECG, electrodes on a subject. The method includes obtaining a 3D anatomical model of the torso of the subject, and obtaining a 3D image of the torso of the subject. The three dimensional image is aligned with the three-dimensional model. A position of each electrode in the three-dimensional model is determined from the three dimensional image. The positions of the electrodes in the three dimensional model are used for estimating the distribution, fluctuation and/or movement of electrical activity through heart tissue.

Abstract: A method for performing location determination of a candidate area of a heart disorder, while applying information from an ECG device and a processing unit: obtaining a torso model and/or a heart model of a subject, for the purpose of determining locations, determining of an origin in the hearts model and torso model, obtaining the location information relating to a number of ECG electrodes relative to the torso model and/or hearts model of the subject, based on the location information in the torso model and/or heart model, positioning of the number of ECG electrodes, obtaining of electrode measuring information related to respective distinct ECG electrodes, constructing weighted vector is based on electrode measuring information while applying a predetermined ECG feature, relating the weighted vectors to the origin and the respective electrodes, based on the weighted vectors relative to the said origin, constructing of an initial anatomical feature vector.

Abstract: The present application relates to a method, such as implemented on a computing device part of and/or coupled to an EGG device, for providing an EGG analysis interface relating to a person, the method comprising steps of: —obtaining data entry identifying the person for obtaining historical data pertaining to at least one preceding data point from a database, —obtaining at least one historical EGG measurement result pertaining to said at least one data point from the database, —obtaining historical EGG electrode location information relating to the electrode placement of the respective at least one data point, —obtaining latest or new EGG electrode location information measurement of electrode positions for a live EGG measurement, —obtaining latest or new EGG measurement results of the person with the location measured electrodes, —performing steps of verification as to differences between the historical EGG electrode location information and the latest or new EGG electrode location information, —assembling t

Abstract: A computer implemented method for processing measurement data from electrocardiogram, ECG, electrodes on a subject. The method includes obtaining a 3D anatomical model of the torso of the subject, and obtaining a 3D image of the torso of the subject. The three dimensional image is aligned with the three-dimensional model. A position of each electrode in the three-dimensional model is determined from the three dimensional image. The positions of the electrodes in the three dimensional model are used for estimating the distribution, fluctuation and/or movement of electrical activity through heart tissue.

Abstract: The present invention relates to a method to be performed by a computing device part of or coupled to an ECG device for estimating an orientation of the heart based on 3-D imaging information taken from a torso, preferably applying a marker element in a process of determining an orientation of a heart, preferably in a torso model of the torso of the human body, more preferably a heart-torso model specifically including data pertaining to the heart of the, preferably human, body, the method comprising steps of: —receiving information relating to the human body from a measurement source, such as dimensional measurement information input into the computing device from an input interface or an optical imaging device, preferably a 3D imaging device, the information relating to the human body comprising: —information of the exterior of the body, at least comprising imaging information of the exterior of the torso, —determining chest dimensions, such as at the xyphoid position

Abstract: The present invention relates to a method to be performed by a computing device part of or coupled to an ECG device for applying a marker element in a process of determining positions of a set of ECG electrodes as placed on a human torso relative to a 3D model of a body, preferably a torso model of the torso of the human body, the method comprising steps of: —receiving an imaging information recording relating to the human body from an optical imaging device, preferably a 3D imaging device, the optical imaging information comprising: —imaging information of the exterior of the body, at least comprising imaging information of the exterior of the torso, —imaging information of the marker element —performing an image recognition on the imaging in formation for obtaining a presence determination, preferably a positive or negative determination, of the marker element in the imaging information.

Abstract: A microfluidic synthesis platform includes a microfluidic chip holder that has a computer controlled heating element and cooling element therein. A microfluidic chip is mountable in the microfluidic chip holder. The microfluidic chip is formed by a hydrophobic substrate having patterned thereon a hydrophilic reaction site and a plurality of hydrophilic channels or pathways extending outward from the hydrophilic reaction site and terminating at respective loading sites on the substrate, wherein the hydrophilic channels or pathways are tapered with an increasing width in an inward direction toward the hydrophilic reaction site.