Abstract: The present disclosure provides monospecific antigen-binding proteins that bind human SLC3A2-APIS and bispecific antigen-binding proteins that bind to SLC3A2-APIS and CD3 (SLC3A2-APISxCD3). In certain embodiments, the disclosed bispecific antigen-binding proteins include a first antigen-binding domain that binds SLC3A2-APIS and a second antigen-binding domain that binds CD3. In some embodiments, the disclosed antigen-binding proteins inhibit tumor growth. In some embodiments, the disclosed antigen-binding proteins ameliorate one or more symptoms of a myelodysplastic syndrome.

Abstract: The present disclosure provides antibody-drug conjugates comprising anti-PTCRA antibodies and methods of using the same. The ADCs of the disclosure are useful for the treatment of T-ALL and other disorders related to elevated expression of PTCRA.

Abstract: The present disclosure provides antibody-drug conjugates comprising anti-PTCRA antibodies and methods of using the same. The ADCs of the disclosure are useful for the treatment of T-ALL and other disorders related to elevated expression of PTCRA.

Abstract: The present disclosure provides antibody-drug conjugates comprising anti-PTCRA antibodies and methods of using the same. The ADCs of the disclosure are useful for the treatment of T-ALL and other disorders related to elevated expression of PTCRA.

Abstract: A light-generated input interface is provided using a combination of components that include a projector and a sensor. The projector displays an image corresponding to an input device. The sensor can be used to detect selection of input based on contact by a user-controlled object with displayed regions of the projected input device. An intersection of a projection area and an active sensor area on a surface where the input device is to be displayed is used to set a dimension of an image of the input device.