Abstract: Systems and devices for producing biological products and methods of using the same are provided. An example universal skid includes a rigid support and a plurality of flow-channel hardware sets. Each flow-channel hardware set couples with a respective flow channel of a plurality of flow channels for unit operations. The flow-channel hardware sets allow the flow channels to operate in parallel or in series for continuous processing over the unit operations. An example modular assembly includes one or more single-use kits for one or more unit operations and a universal skid coupled with the one or more single-use kits. An example manufacturing system includes multiple modular assemblies coupled with each other allowing continuous processing within each modular assembly, in between the modular assemblies, fully continuous processing across multiple unit operations.

Abstract: The present disclosure relates to methods and systems for the continuous production of recombinant proteins. In particular embodiments, the disclosure relates to methods and systems using capture chromatography, post-capture chromatography, virus filtration, and ultrafiltration/diafiltration for the continuous production of recombinant proteins.

Abstract: A method for producing an asphalt concrete blend that includes the steps of drying and heating aggregate in a single and only dryer, preferably via direct heating, and without use of a pre-dryer. The aggregate is then combined with asphalt cement, preferably via indirect heating, such that the blend has an asphalt cement components (ACC) percentage of at least 25% percent to form an aggregate mix. Liquid asphalt cement may also be added to the aggregate mix. Preferably, the asphalt cement content of the final asphalt concrete blend is provided by a maximum of 70% ACC. In certain cases, the asphalt cement content of the asphalt concrete blend is comprised of ACC and liquid asphalt cement.

Abstract: A method for producing an asphalt concrete blend that includes the steps of drying and heating aggregate in a single and only dryer, preferably via direct heating, and without use of a pre-dryer. The aggregate is then combined with asphalt cement, preferably via indirect heating, such that the blend has an asphalt cement components (ACC) percentage of at least 25% percent to form an aggregate mix. Liquid asphalt cement may also be added to the aggregate mix. Preferably, the asphalt cement content of the final asphalt concrete blend is provided by a maximum of 70% ACC. In certain cases, the asphalt cement content of the asphalt concrete blend is comprised of ACC and liquid asphalt cement.

Abstract: The present invention relates to a hand-held abrasive article. In one embodiment, the hand-held abrasive article includes an elongated resilient body having a perpendicular cross-sectional surface. The cross-sectional surface of the resilient body includes at least one internal right angle, at least one internal acute angle, at least one internal obtuse angle, and at least one curved portion. At least a portion of the resilient body is coated with abrasive.

Abstract: The invention is an animal carrier product for carrying an animal on a cycle. The product is mounted to the cycle at a saddlebag position to provide a low center of gravity while the cycle is in use. The product is mounted at the saddlebag position to enable the cycle to carry a human passenger in a typical passenger position behind a cycle driver. Some embodiments of the product are configured to mount interchangeably with a commercially-available saddlebag cargo container, utilizing the mounting bracket provided with the commercially-available saddlebag cargo container.

Abstract: An embodiment of a method of predicting maternal hypertension during pregnancy is disclosed. The method may include measuring a maternal blood velocity waveform and measuring a fetal blood velocity waveform. The method may further include the calculation of a coherence value using a magnitude-squared coherence function between the maternal and fetal blood velocity waveforms and comparing the coherence value to a predetermined threshold value.