Abstract: The invention relates to an intramedullary locking bone screw for fixing the metatarsophalangeal joint of the big toe in foot surgery that can be completely received in the bone, said locking bone screw extending along a longitudinal axis (L), with a first outside thread section (6) having a first thread pitch and with at least one second outside thread section (7), preferably designed to be self-tapping, having a pitch that is different from the first thread pitch.

Abstract: The invention relates to an intramedullary locking bone screw for fixing the metatarsophalangeal joint of the big toe in foot surgery that can be completely received in the bone, said locking bone screw extending along a longitudinal axis (L), with a first outside thread section (6) having a first thread pitch and with at least one second outside thread section (7), preferably designed to be self-tapping, having a pitch that is different from the first thread pitch.

Abstract: The invention relates to an orthopedic compression screw, in particular a compression screw for osteosynthesis and/or fixation of bone segments (12, 14), with a threaded portion (20) and a screw head (18), the screw head (18) widening conically toward its distal end and the screw being provided along its longitudinal axis (A) with a bore (26) for interaction with an orthopedic guide element, in particular a guide wire, and the periphery of the screw head (18) having at least one flat that forms a plane outer surface (30) preferably extending parallel to the longitudinal axis.

Abstract: A method of treating a neurodegenerative disease in a subject in need thereof comprises: (a) administering the subject an ornithine decarboxylase inhibitor such as alpha-difluoromethylornithine or a pharmaceutically acceptable salt or prodrug thereof in an amount effective to treat the disease; and concurrently (b) administering the subject a polyamine or a pharmaceutically acceptable salt or prodrug thereof in an amount effective to reduce damage to the gastroinestinal tract of the subject by the ornithine decarboxylase inhibitor.