Abstract: Disclosed herein are compounds of formula I: or a pharmaceutically acceptable salt thereof, where the variables are as defined herein. These compounds are useful in treating RET associated cancers. Formulations containing the compounds of formula I and methods of making the compounds of formula I are also disclosed.

Abstract: Provided herein are RET kinase inhibitors according to the formula: pharmaceutically acceptable salts thereof, pharmaceutical compositions thereof, and methods for their use in the treatment of diseases that can be treated with a RET kinase inhibitor, including RET-associated diseases and disorders. A, R1, n, X1, X2, X3, X4, and R2 have the meanings given in the specification.

Abstract: Systems and methods for user identification and authentication are disclosed. In one embodiment, a method of authenticating a first party to a second party may include the following: (1) receiving, from one of an electronic device of a first party and an electronic device of a second party, a request to generate authenticating indicia; (2) using at least one of a plurality of computer processors, generating the authenticating indicia; (3) transmitting, over a network, the authenticating indicia to the electronic device of a first party and to the electronic device of the second party; (4) receiving, from an electronic device of the second party, an indication that the second party has confirmed that the first party is authentic; and (5) storing an identity of the first party, the second party, and the authenticating indicia in a database.

Abstract: Systems and methods for user identification and authentication are disclosed. In one embodiment, a method of authenticating a first party to a second party may include the following: (1) receiving, from one of an electronic device of a first party and an electronic device of a second party, a request to generate authenticating indicia; (2) using at least one of a plurality of computer processors, generating the authenticating indicia; (3) transmitting, over a network, the authenticating indicia to the electronic device of a first party and to the electronic device of the second party; (4) receiving, from an electronic device of the second party, an indication that the second party has confirmed that the first party is authentic; and (5) storing an identity of the first party, the second party, and the authenticating indicia in a database.

Abstract: Systems and methods for user identification and authentication are disclosed. In one embodiment, a method of authenticating a first party to a second party may include the following: (1) receiving, from one of an electronic device of a first party and an electronic device of a second party, a request to generate authenticating indicia; (2) using at least one of a plurality of computer processors, generating the authenticating indicia; (3) transmitting, over a network, the authenticating indicia to the electronic device of a first party and to the electronic device of the second party; (4) receiving, from an electronic device of the second party, an indication that the second party has confirmed that the first party is authentic; and (5) storing an identity of the first party, the second party, and the authenticating indicia in a database.

Abstract: A graphical method and system of tracking projects managed in accordance with Theory of Constraints project management techniques. A graph of project and feeding chain buffer consumption is constructed for at a glance project status review by management. Alternate buffer consumption models may be utilized.

Abstract: The integrity of a signal path through a transmission system (12), which processes successive blocks (14) of data during a given time frame, verified by establishing the parity of a selected one of the blocks as it enters and as it leaves the system. A lack of equality between the parities is indicative of a lack of path integrity.

Abstract: Disclosed is a communications network for peripherals in a digital loop carrier transmission system. A broadcast STAR network is employed so that all peripherals receive any message which is broadcast by any of the peripherals. No peripheral broadcasts without clearance from the active communications hub. Two hubs can be provided to alternatively act as the active hub. Each peripheral includes a controller which transmits a request to send signal, multiplexes the request to send signal with an outgoing message, receives clear to send signals, and demultiplexes the clear to send signals from an incoming message.

Abstract: When the input power from a resistive source to a DC-DC converter decreases, the pulse width of the switching transistor increases for a given load. When the pulse width increases above a threshold (14), a Schmidt Trigger (36) will operate to generate a plurality of control signals (42,44,46). The threshold is set by a plurality of resistors (28,30,32,34). In response to the control signals (42,46,48), telecommunications traffic through a remote carrier terminal will be adjusted.

Abstract: A control circuit (36) on the primary side of a converter senses the output voltage and is useful for modulating the drive pulse width of a switching transistor (30). An averaging circuit (78) averages the drive pulse and compares this average with an average of the drive pulses for all switching transistors in a system of parallel converters to produce an error signal. In response to the error signal, the drive pulse width is varied so that the load current is distributed evenly among the parallel converters to improve the system efficiency.