Patents by Inventor Michael W. Hager

Michael W. Hager has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • N4-HYDROXYCYTIDINE AND DERIVATIVES AND ANTI-VIRAL USES RELATED THERETO
    Publication number: 20250064844
    Abstract: This disclosure relates to certain N4-hydroxycytidine derivatives, pharmaceutical compositions, and methods related thereto. In certain embodiments, the disclosure relates to the treatment or prophylaxis of human coronavirus 2019-nCoV.
    Type: Application
    Filed: November 7, 2024
    Publication date: February 27, 2025
    Inventors: George R. PAINTER, Gregory R. BLUEMLING, Michael G. NATCHUS, Shuli MAO, Jose MARENGO, Michael W. HAGER, David PERRYMAN
  • N4-HYDROXYCYTIDINE AND DERIVATIVES AND ANTI-VIRAL USES RELATED THERETO
    Publication number: 20210252033
    Abstract: This disclosure relates to certain N4-hydroxycytidine derivatives, pharmaceutical compositions, and methods related thereto. In certain embodiments, the disclosure relates to the treatment or prophylaxis of human coronavirus 2019-nCoV.
    Type: Application
    Filed: February 8, 2021
    Publication date: August 19, 2021
    Inventors: George R. PAINTER, Gregory R. BLUEMLING, Michael C. NATCHUS, Shuli MAO, Jose MARENGO, Michael W. HAGER, David PERRYMAN
  • GRAM-POSITIVE CARBAPENEM ANTIBACTERIALS AND PROCESSES FOR THEIR PREPARATION
    Publication number: 20100075945
    Abstract: The present invention provides ?-methyl carbapenem compounds and pharmaceutical compositions useful in the treatment of bacterial infections and methods for treating such infections using such compounds and/or compositions. The invention includes administering an effective amount of a carbapenem compound or salt and/or prodrug thereof to a host in need of such a treatment. The present invention is also in the field of synthetic organic chemistry and is specifically provides an improved method of synthesis of ?-methyl carbapenems which are useful as antibacterial agents.
    Type: Application
    Filed: November 6, 2009
    Publication date: March 25, 2010
    Inventors: Woo-Baeg Choi, David S. Menaldino, Deog-II Kim, Martin Bouygues, Michael W. Hager
  • Gram-positive carbapenem antibacterials and processes for their preparation
    Patent number: 7632828
    Abstract: The present invention provides ?-methyl carbapenem compounds and pharmaceutical compositions useful in the treatment of bacterial infections and methods for treating such infections using such compounds and/or compositions, wherein the compounds are generally of the Formulae The invention includes administering an effective amount of a carbapenem compound or salt and/or prodrug thereof to a host in need of such a treatment. The present invention is also in the field of synthetic organic chemistry and is specifically provides an improved method of synthesis of ΓΏ-methyl carbapenems which are useful as antibacterial agents.
    Type: Grant
    Filed: June 10, 2005
    Date of Patent: December 15, 2009
    Assignee: FOB Synthesis, Inc.
    Inventors: Woo-Baeg Choi, David S. Menaldino, Deog-Il Kim, Martin Bouygues, Michael W. Hager
  • Preparation of 3'-substituted-2',3'-dideoxynucleosides and 2'-deoxynucleosides from acyclic, achiral precursors
    Patent number: 5432273
    Abstract: A process for the preparation of 3'-substituted-2',3'-dideoxynucleosides is provided that utilizes inexpensive, non-carbohydrate, acyclic, achiral starting materials and that proceeds with high enantiomeric and stereochemical control. The method can be used to prepare the pharmaceutically important compounds 3'-azido-3'-deoxythymidine, 3'-azido-2',3'-dideoxyuridine, 3'-fluoro-3'-deoxythymidine, and 3'-fluoro-3'-deoxyuridine.
    Type: Grant
    Filed: October 14, 1992
    Date of Patent: July 11, 1995
    Assignee: Emory University
    Inventors: Dennis C. Liotta, Michael W. Hager
  • Preparation of 3'-substituted-2',3'-dideoxynucleosides and 2'-deoxynucleosides from acyclic, achiral precursors
    Patent number: 5414078
    Abstract: A process for the preparation of 3'-substituted-2',3'-dideoxynucleosides and 2'-deoxynucleosides is provided that utilizes inexpensive, non-carbohydrate, acyclic, achiral starting materials and that proceeds with high enantiomeric and stereochemical control. The method can be used to prepare the pharmaceutically important compounds 3'-azido-3'-deoxythymidine, 3'-azido-2',3'-dideoxyuridine and 3'-fluoro-3'-deoxythymidine.
    Type: Grant
    Filed: April 5, 1991
    Date of Patent: May 9, 1995
    Assignee: Emory University
    Inventors: Dennis C. Liotta, Michael W. Hager