Abstract: An endoluminal prosthesis that includes a support structure comprising a curvilinear portion having a first strut and a second strut that meet at an apex. Disposed on the support structure is an anchor with an anchor body and one or more barbs extending outwardly from the anchor body and where the anchor body fits at least partially about, and conforms to the first strut, second strut, and the apex.

Abstract: An embolization device for occluding a body vessel cavity defined by a cavity wall is disclosed. The device includes an inflatable balloon made of a permeable material. The balloon is configured to have a deflated state and an inflated state and includes a proximal portion having an inflation hole formed therethrough to a cavity within the balloon. An inflation member is removably attached to the proximal portion and is configured to introduce a material in the cavity by way of the hole for inflation of the balloon. The permeable material is configured to allow inflation of the balloon and a portion of the solidifiable material to pass through the permeable material for contact with the cavity wall. The inflation member is configured to transmit, for example, ultra violet light to cure a solidifiable material, thereby maintaining the balloon in the inflated state and to adhering the balloon to the cavity wall.

Abstract: The invention relates to minimally invasive device for delivering therapeutic or diagnostic agents into a vessel wall. The device includes an introducer tube, a tubular member having a proximal end, a distal end, and a first lumen extending therebetween, the tubular member being slidably disposed within the introducer tube; a plurality of hollow delivery struts, each delivery strut adapted to pierce through inner most layers of the vessel wall and each comprising at least one exit port and at least one stopper to prevent the delivery strut from piercing through the outer most layers of the vessel wall. The delivery struts are disposed on the distal end of the tubular member and are in fluid communication with the first lumen. The invention also relates to methods of delivering the device of this invention and methods of treating conditions or diseases of body lumens.

Abstract: A balloon catheter is provided that may be used to dilate hardened regions of a stenosis. The balloon catheter is provided with dilation elements that extend along a surface of a balloon. The dilation elements may comprise a coil and dilation wire. The coil and wire may be configured in various ways such that inflation of the balloon creates a concentration of forces along the dilating wires which are thereafter transmitted to stenosed regions of a vessel wall. The force exerted by the dilation elements against the stenosed region is sufficient to fracture plaque from the vessel wall.

Abstract: A method for closing a body opening in a patient is disclosed. The method comprises positioning a delivery catheter within the body opening. The delivery catheter includes a closure device comprising a distal occluding body and a proximal occluding body. The closure device is collapsibly disposed within a distal end of the delivery catheter. The method further includes deploying the closure device from the delivery catheter about the body opening such that a distal frame of the distal occluding body expands to its expanded configuration at a distal end of the body opening and a proximal frame of the proximal occluding body expands to its expanded configuration at an opposing proximal end of the body opening.

Abstract: A suture retention device is provided for retaining a suture. The device includes a body with a channel and two retention members within the channel. The retention members are movable between an unlocked state to a locked state in which the suture is restrained with respect to the body.

Abstract: The present disclosure provides apparatus and methods for removing thrombus outside of a hemodialysis. The hemodialysis catheter comprises an elongate shaft comprising a plurality of lumens. A first lumen has a first distal port. The first lumen is configured for the flow of a fluid in a first direction. A second lumen has a second distal port proximal to the first distal port. The second lumen is configured for the flow of the fluid in a second direction opposite to the first direction. A third lumen has a third distal port proximal to the second distal port. An elongate device is disposed through the third lumen. The elongate device has an operable member on a distal end or a device to connect to an operable member disposed on the elongate shaft. The operable member is configured to engage and remove thrombus from an exterior surface on the elongate shaft.

Abstract: A spring action medical device includes a spring that may propel a hammer component in a distal direction when the spring is released from a loaded state. When propelled forward by the spring, the hammer component makes contact with a distal tip of the medical device. The distal tip may then transfer a force to an external object, such as an occlusion in a body lumen.

Abstract: A medical wire guide may include a mandrel and a cannula disposed about a portion of the mandrel. A spring may be coupled with the mandrel. The spring may be placed in a loaded state in response to relative displacement between the mandrel and the cannula. Upon release from the loaded state, the spring is configured to bias the mandrel in a distal direction relative to the cannula.

Abstract: In at least one embodiment of the present invention, a retrieval device for entrapping and retaining a foreign object located in a body vessel for its extraction therefrom is provided. The device comprises a cage having a proximal end and a distal end and a longitudinal axis extending between the proximal and distal ends. The cage is radially expandable about the longitudinal axis to define an expanded state and to form an opening at the distal end for receiving the foreign object. The cage is collapsible to define a collapsed state and to retain the foreign object therein such that the foreign object is substantially aligned with the longitudinal axis. Extending proximally from the proximal end of the cage is a cable for retrieval of the device in the collapsed state.

Abstract: A hemodialysis catheter with a plurality of umbrella-like wire members covered with a film which works as a thrombus blocker and can easily and effectively remove the thrombus is disclosed. The hemodialysis catheter has a proximal lumen, the arterial lumen, and a distal lumen, the venous lumen. An elongate member is longitudinally put in either the proximal lumen or the distal lumen, or two elongate members in both lumens. A plurality of umbrella-like wire members are connected to the end of the elongate member. When the hemodialysis catheter is put in the vessel but not in use, the end of the lumen is capped off by the plurality of umbrella-like wire members covered with a film. When it is ready to use, the doctor can pull the elongate member which connects to the plurality of umbrella-like wire members out off the lumen inverting the plurality of umbrella-like wire members and clearing away any thrombus that has formed.

Abstract: An integrally formed angioplasty cutting device for balloon angioplasty of a stenotic lesion in a body vessel. The device comprises a distal collar and a proximal collar. The device further comprises at least one strut integrally formed with the distal collar and the proximal collar. At least one of the collars has a slot formed therethrough defining a C-shaped configuration. The strut is configured to be disposed at the stenotic lesion to engage the stenotic lesion for dilatation of the body vessel during angioplasty.

Abstract: A method for closing a body opening in a patient is disclosed. The method comprises positioning a delivery catheter within the body opening. The delivery catheter includes a closure device comprising a distal occluding body and a proximal occluding body. The closure device is collapsibly disposed within a distal end of the delivery catheter. The method further includes deploying the closure device from the delivery catheter about the body opening such that a distal frame of the distal occluding body expands to its expanded configuration at a distal end of the body opening and a proximal frame of the proximal occluding body expands to its expanded configuration at an opposing proximal end of the body opening.

Abstract: A locking mechanism (15) for a catheter includes a main body (20), a tip (30), and a locking arm (50). The locking arm includes a pivotable portion (56) selectively receivable in a contoured outer surface portion of the main body (24). One end of a tubular member is engageable with the distal end of the tip, and the other end is insertable into a body cavity, e.g., for drainage of fluid therefrom. A tension member (14), e.g. suture, extends through the locking mechanism and the tubular member, and is actuable to maneuver the inserted end of the tubular member into a desired configuration, such as a loop or a pigtail (12). An end of the tension member is receivable along the main body contoured surface following actuation, and is lockable therein upon receipt of the locking arm pivotable portion in the contoured surface, thereby locking the tubular member end in the desired configuration.

Abstract: The invention relates to minimally invasive device for delivering therapeutic or diagnostic agents into a vessel wall. The device includes an introducer tube, a tubular member having a proximal end, a distal end, and a first lumen extending therebetween, the tubular member being slidably disposed within the introducer tube; a plurality of hollow delivery struts, each delivery strut adapted to pierce through inner most layers of the vessel wall and each comprising at least one exit port and at least one stopper to prevent the delivery strut from piercing through the outer most layers of the vessel wall. The delivery struts are disposed on the distal end of the tubular member and are in fluid communication with the first lumen. The invention also relates to methods of delivering the device of this invention and methods of treating conditions or diseases of body lumens.

Abstract: A repositionable closure device for occluding a body opening is provided. The closure device includes distal and proximal occluding bodies having expandable distal and proximal umbrella frames. Each umbrella frame includes a plurality of struts connected to a biocompatible sheet material. The distal and proximal umbrella frames expand to expanded configurations on opposite sides of the body opening. The struts of the distal umbrella frame terminate with an eyelet. The distal occluding body is connected to a distal end of a center rod and the proximal umbrella frame is slidable along the center rod via a center ring. At least one drawstring is threaded through the eyelets and the center ring, connecting the distal and proximal occluding bodies. The drawstring extends proximally from the center ring. Manipulation of the drawstring and the center rod is configured to collapse the closure device for at least partial retrieval during repositioning.

Abstract: An apparatus and method for making an occlusion device for occluding a body vessel. The apparatus and method include providing a frame and a mandrel. The frame has a hub extending along a longitudinal axis from a proximal end to a distal end. A plurality of arcuate legs are attached to the hub and extend distally. The arcuate legs are flexible and have inner surfaces defining an inner profile in an unconstrained state. The mandrel has an outer surface corresponding to the inner profile of the occlusion device. A base layer of a biocompatible material is disposed on the outer surface of the mandrel. The frame is placed on the outer surface with the base layer between the frame and the mandrel. The frame is attached to the base layer such that the biocompatible material forms a membrane extending along and between the arcuate legs.

Abstract: The invention relates to minimally invasive device for delivering therapeutic or diagnostic agents into a vessel wall. The device includes an introducer tube, a tubular member having a proximal end, a distal end, and a first lumen extending therebetween, the tubular member being slidably disposed within the introducer tube; a plurality of hollow delivery struts, each delivery strut adapted to pierce through inner most layers of the vessel wall and each comprising at least one exit port and at least one stopper to prevent the delivery strut from piercing through the outer most layers of the vessel wall. The delivery struts are disposed on the distal end of the tubular member and are in fluid communication with the first lumen. The invention also relates to methods of delivering the device of this invention and methods of treating conditions or diseases of body lumens.

Abstract: The present disclosure provides apparatus and methods for removing thrombus outside of a hemodialysis. The hemodialysis catheter comprises an elongate shaft comprising a plurality of lumens. A first lumen has a first distal port. The first lumen is configured for the flow of a fluid in a first direction. A second lumen has a second distal port proximal to the first distal port. The second lumen is configured for the flow of the fluid in a second direction opposite to the first direction. A third lumen has a third distal port proximal to the second distal port. An elongate device is disposed through the third lumen. The elongate device has an operable member on a distal end or a device to connect to an operable member disposed on the elongate shaft. The operable member is configured to engage and remove thrombus from an exterior surface on the elongate shaft.

Abstract: A repositionable closure device for occluding a body opening is provided. The closure device includes distal and proximal occluding bodies having expandable distal and proximal umbrella frames. Each umbrella frame includes a plurality of struts connected to a biocompatible sheet material. The distal and proximal umbrella frames expand to expanded configurations on opposite sides of the body opening. The struts of the distal umbrella frame terminate with an eyelet. The distal occluding body is connected to a distal end of a center rod and the proximal umbrella frame is slidable along the center rod via a center ring. At least one drawstring is threaded through the eyelets and the center ring, connecting the distal and proximal occluding bodies. The drawstring extends proximally from the center ring. Manipulation of the drawstring and the center rod is configured to collapse the closure device for at least partial retrieval during repositioning.